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Category: biotech/medical – Page 1323

Donor-derived anti-CD7 chimeric antigen receptor (CAR) T-cell therapy led to complete responses in 18 of 20 patients with relapsed or refractory (r/r) T-cell acute lymphoblastic (ALL), a first-in-human clinical trial showed.

After a median follow-up of 6.3 months, 15 of the 18 responding patients remained in remission, and seven patients had undergone stem-cell transplantation (SCT). All patients developed cytokine release syndrome (CRS), which was grade 1/2 in most instances. Because the therapy involved unmanipulated T cells, a majority of patients developed graft-versus-host disease (GVHD), grade 1/2 severity in all cases. All of the patients developed severe cytopenias, which were manageable.

The results provided the basis for an ongoing phase II trial of the donor-derived anti-CD7 therapy, reported Jing Pan, MD, of the State Key Laboratory of Experimental Hematology and Beijing Boren Hospital in China, and colleagues in the Journal of Clinical Oncology.

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An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to a study published in the Journal of Clinical Investigation.

Researchers from the University of Arizona, in collaboration with Stony Brook University and Wake Forest School of Medicine, analyzed blood samples from two COVID-19 patient cohorts and found that circulation of the enzyme — secreted phospholipase A2 group IIA, or sPLA2-IIA, — may be the most important factor in predicting which patients with severe COVID-19 eventually succumb to the virus.

Researchers have identified what may be the key molecular mechanism responsible for COVID-19 mortality – an enzyme related to neurotoxins found in rattlesnake venom.

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The robots can tumble up slopes.

A new study investigates tiny tumbling soft robots that can be controlled using rotating magnetic fields. The technology could be useful for delivering drugs to the nervous system. In this latest study, researchers put the robots through their paces and showed that they can climb slopes, tumble upstream against fluid flow and deliver substances at precise locations to neural tissue.

Would you let a tiny MANiAC travel around your nervous system to treat you with drugs? You may be inclined to say no, but in the future, “magnetically aligned nanorods in alginate capsules” (MANiACs) may be part of an advanced arsenal of drug delivery technologies at doctors’ disposal. A recent study in Frontiers in Robotics and AI is the first to investigate how such tiny robots might perform as drug delivery vehicles in neural tissue. The study finds that when controlled using a magnetic field, the tiny tumbling soft robots can move against fluid flow, climb slopes and move about neural tissues, such as the spinal cord, and deposit substances at precise locations.

Diseases in the central nervous system can be difficult to treat. “Delivering drugs orally or intravenously, for example, to target cancers or neurologic diseases, may affect regions of the body and nervous system that are unrelated to the disease,” explained Lamar Mair of Weinberg Medical Physics, a medical device company based in the US and an industrial partner on the study. “Targeted drug delivery may lead to improved efficacy and reduced side-effects due to lower off-target dosing.”

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For those who dream of visiting Peru’s Machu Picchu, a new virtual reality (VR) exhibit is set to fully immerse guests in the wonders of the UNESCO World Heritage site.

Debuting this October at the Boca Raton Museum of Art in Florida, the Machu Picchu and the Golden Empires of Peru exhibition is the first of its kind, offering a full-motion, 360-degree, interactive VR experience. Guests can expect to experience the ruins of Machu Picchu as if they were there in person, all while also learning about the ancient civilizations of Peru.

In order to preserve this historic site, less than one million visitors are allowed in each year. During the pandemic, that number dropped to approximately 250,000 to allow for social distancing. But with the Machu Picchu and the Golden Empires of Peru exhibition, the goal is for as many people as possible to experience these impressive ruins.

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Summary: Novel AI technology allows researchers to understand which brain regions directly interact with each other, which helps guide the placement of electrodes for DBS to treat neurological diseases.

Source: Mayo Clinic.

For millions of people with epilepsy and movement disorders such as Parkinson’s disease, electrical stimulation of the brain already is widening treatment possibilities. In the future, electrical stimulation may help people with psychiatric illness and direct brain injuries, such as stroke.

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Antibacterial, antifungal, antiviral, and antiparasitic treatments developed in the past century have improved survival outcomes, even in high-mortality conditions such as sepsis, a condition that is mostly caused by bacteria but can also be due to other infections. In the 21st century, of all therapies that have improved the outcomes of patients with sepsis, the appropriate and early administration of antibiotics has been shown to be the most effective therapy to save lives.… See More.

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International research team isolates DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

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