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Category: biotech/medical – Page 1,265

WHO expert cancer group states that the sweetener aspartame is a possible carcinogen, but evidence is limited — 6 questions answered

Assessments of the health impacts of the non-sugar sweetener aspartame are released today by the International Agency for Research on Cancer (IARC) and the World Health Organization (WHO) and the Food and Agriculture Organization (FAO) Joint Expert Committee on Food Additives (JECFA). Citing “limited evidence” for carcinogenicity in humans, IARC classified aspartame as possibly carcinogenic to humans (IARC Group 2B) and JECFA reaffirmed the acceptable daily intake of 40 mg/kg body weight. Aspartame is an artificial (chemical) sweetener widely used in various food and beverage products since the 1980s, including diet drinks, chewing gum, gelatin, ice cream, dairy products such as yogurt, breakfast cereal, toothpaste and medications such as cough drops and chewable vitamins.

https://www.who.int/news/item/14-07-2023-aspartame-h…s-released

An expert panel found a potential association with liver cancer, but too little research exists to assume a causal connection. For now, the WHO left current consumption guidelines unchanged.

How Bacteriophages can Boost Microbial Evolution

Bacterial cells can easily share genes with one another, and have a few ways to do so. Viruses called bacteriophages infect bacterial cells, and they can also transfer genes between bacterial cells in a process known as transduction. Often, the genes that are being shared confer resistance to a drug, and once a bacterial cell gains the ability, antibiotic resistance can easily spread through populations of microbial cells. Now scientists have discovered another mechanism that bacteria use to share genes, and it can help microbes evolve even faster than we knew. The findings have been reported in Cell.

There are three types of transduction that we now know about: generalized, specialized, and lateral. The newly revealed mechanism is called lateral cotransduction. It is about as rapid as lateral transduction, which itself is far faster than generalized transduction. However, the study indicated that lateral cotransduction is more complex and versatile than the other modes of transduction. Lateral transduction happens when phages that have integrated into bacterial genomes are reactivated, and trigger reproduction in the lytic cycle; but lateral cotransduction can while new bacterial cells are being infected, and during the reactivation process.

Dopamine Neurons More Diverse than Previously Thought

Dopamine is a type of neurotransmitter that can provide an intense feeling of reward. It has been a long-standing assumption that most, if not all, dopamine neurons solely respond to rewards or reward-predicting cues. However, a study in mice led by researchers at Northwestern University reveals dopamine may also control movements. The researchers uncovered that one genetic subtype fires when the body moves and that these neurons do not respond to rewards at all.

The findings are published in Nature Neuroscience in an article titled, “Unique functional responses differentially map onto genetic subtypes of dopamine neurons,” and shed new light on the brain which may lead to new research on Parkinson’s disease, which is characterized by the loss of dopamine neurons yet affects the motor system.

“Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli,” the researchers wrote. “Dopamine neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three genetic dopamine subtypes within the substantia nigra pars compacta, characterized by the expression of Slc17a6 (Vglut2), Calb1, and Anxa1, each have a unique set of responses to rewards, aversive stimuli, and accelerations and decelerations, and these signaling patterns are highly correlated between somas and axons within subtypes.”

Police use drone to find missing person with dementia

The device was equipped with infrared technology.

A police drone equipped with infrared capabilities has risen as a hero in the search for a missing person with dementia that disappeared from a Delta hospital on July 29. Delta is a city located in British Columbia, Canada.

This is according to a report by Global News published on Wednesday.

Interesting Engineering is a cutting edge, leading community designed for all lovers of engineering, technology and science.

Powerful gene editing approach boosts rotifers in pantheon of laboratory animals

Rotifers are excellent research organisms for studying the biology of aging, DNA repair mechanisms, and other fundamental questions. Now, using an innovative application of CRISPrCas9, scientists at the Marine Biological Laboratory, Woods Hole, have devised a method for making precise, heritable changes to the rotifer genome, enabling the larger community of scientists to deploy the rotifer as a genetically tractable lab organism.

CDC detects coronavirus, HIV, hepatitis and herpes at unlicensed California lab

Local and federal authorities spent months investigating a warehouse in Fresno County, California, that they suspect was home to an illegal, unlicensed laboratory full of lab mice, medical waste and hazardous materials.

The Fresno County Public Health Department has been “evaluating and assessing the activities of an unlicensed laboratory” in Reedley, the health department’s assistant director, Joe Prado, said in a statement Thursday. All of the biological agents were destroyed by July 7 following a legal abatement process by the agency.

“The evaluation required coordination and collaboration with multiple federal and state agencies to determine and classify biological and chemical contents onsite, in addition to assessing jurisdictional authority under this unique situation,” Prado said.

The Lunar Codex Will Archive the Work of 30,000 Artists—on the Moon

When Samuel Peralta contacts artists about putting their work on the moon, they don’t always believe him.

“I say, ‘I’d like to put your art on the moon,’ and they think this is some sort of a scam,” the semiretired physicist and author tells the New York Times’ J. D. Biersdorfer.

But it’s true. Peralta is the mastermind behind the Lunar Codex, a series of time capsules containing the work of 30,000 artists from 157 countries that will journey to the lunar surface. Peralta wants the project to honor artists after the difficulties they faced during the pandemic, he tells the Toronto Star’s Kevin Jiang.

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