Health Canada is updating the labels for the AstraZeneca and Johnson & Johnson COVID-19 vaccines to add immune thrombocytopenia (ITP), an autoimmune condition, as a potential side effect.
In a statement on Tuesday, the agency said very rare cases of ITP have been reported internationally after receiving the Vaxzevria (AstraZeneca) and Janssen (J&J) COVID-19 vaccines.
ITP is a disorder that can cause easy or excessive bruising and bleeding, which results from unusually low blood platelet levels.
Previously unrecognized control point identified as target for drugs that block transition. A new study led by University of California, Irvine researchers is the first to reveal the specific molecular mechanism that controls the transition from acute to chronic pain, and identifies this mechanism as a critical target for disease-modifying medicines.
Findings from the study, titled “NAAA-regulated lipid signaling governs the transition from acute to chronic pain,” published today in Science Advances, show that disabling N-acylethanolamine acid amidase (NAAA) — an intracellular enzyme-in the spinal cord during a 72 hour time window following peripheral tissue injury halts chronic pain development in male and female mice.
“Delineating the nature, localization and timing of the events involved in pain chronicity is necessary to pinpointing control nodes in the process that can be targeted by new classes of disease-modifying medicines beyond analgesics,” said Daniele Piomelli, Distinguished Professor in the UCI School of Medicine Department of Anatomy & Neurobiology. “This study is the first to identify that NAAA, a previously unrecognized control node, can be effectively targeted by small-molecule therapeutics that inhibit this enzyme, and block the transition from acute to chronic pain.”
NVIDIA has launched a follow-up to the Jetson AGX Xavier, its $1,100 AI brain for robots that it released back in 2018. The new module, called the Jetson AGX Orin, has six times the processing power of Xavier even though it has the same form factor and can still fit in the palm of one’s hand. NVIDIA designed Orin to be an “energy-efficient AI supercomputer” meant for use in robotics, autonomous and medical devices, as well as edge AI applications that may seem impossible at the moment.
The chipmaker says Orin is capable of 200 trillion operations per second. It’s built on the NVIDIA Ampere architecture GPU, features Arm Cortex-A78AE CPUs and comes with next-gen deep learning and vision accelerators, giving it the ability to run multiple AI applications. Orin will give users access to the company’s software and tools, including the NVIDIA Isaac Sim scalable robotics simulation application, which enables photorealistic, physically-accurate virtual environments where developers can test and manage their AI-powered robots. For users in the healthcare industry, there’s NVIDIA Clara for AI-powered imaging and genomics. And for autonomous vehicle developers, there’s NVIDIA Drive.
The company has yet to reveal what the Orin will cost, but it intends to make the Jetson AGX Orin module and developer kit available in the first quarter of 2022. Those interested can register to be notified about its availability on NVIDIA’s website. The company will also talk about Orin at NVIDIA GTC, which will take place from November 8th through 11th.
Discussing The Future Of “Seno-Therapeutic” Development — Dr. Judith Campisi, PhD, Professor of Biogerontology, Buck Institute for Research on Aging.
Dr. Judith Campisi, PhD (https://www.buckinstitute.org/lab/campisi-lab/) is a biochemist, cell biologist, and Professor of Biogerontology at the Buck Institute for Research on Aging.
Dr. Campisi received a PhD in biochemistry from the State University of New York at Stony Brook and completed her postdoctoral training in cell cycle regulation at the Dana-Farber Cancer Institute and Harvard Medical School. As an assistant and associate professor at the Boston University Medical School, she studied the role of cellular senescence in suppressing cancer and soon became convinced that senescent cells also contributed to aging. She joined the Lawrence Berkeley National Laboratory as a senior scientist in 1991 working with Dr. Mina Bissell. In 2,002 she started a second laboratory at the Buck Institute. At both institutions, Dr. Campisi established a broad program to understand the relationship between aging and age-related disease, with an emphasis on the interface between cancer and aging.
Shokrollah Elahi led a new study showing that short-lived white blood cells called neutrophils play a role in impaired T cell functions and counts in people with HIV, as well as the chronic inflammation that is common with the virus. (Photo: Najmeh Bozorgmehr)
In a groundbreaking study of people living with HIV, University of Alberta researchers found that elusive white blood cells called neutrophils play a role in impaired T cell functions and counts, as well as the associated chronic inflammation that is common with the virus.
Neutrophils are a foundational part of the body’s immune system and the most abundant type of white blood cell, making up about 60 to 80 per cent of circulating immune cells in the blood. However, unlike other types of white blood cells, neutrophils are extremely short-lived and cannot be frozen and thawed like other immune cells, making them extremely difficult to examine, said study lead Shokrollah Elahi.
“Neutrophils live for hours to a day or two maximum,” Elahi said. “The body produces a lot of neutrophils, and they do their job and then they die and have to be regenerated in the bone marrow. But despite the fact that neutrophils are the most abundant white blood cells in the blood circulation, their role in the context of HIV has not been very well defined.”
Wastewater samples are being used to track the spread of SARS-CoV-2.
It’s sometimes called ‘wastewater-based epidemiology’ (WBE) – a scientific and public health field that involves detecting and monitoring specific molecules in untreated wastewater, to determine how prevalent they are. First proposed more than 70 years ago as a way to track the spread of the deadly poliovirus, WBE has since been used to measure human population exposure to pollutants, and even to estimate the level of drug consumption in major cities. In 2,020 it hit global news headlines when it was first proposed as a way to track SARS-CoV-2, the virus that causes COVID-19.
You’ve heard the phase “we are all made of star-stuff,” attributed to the late astronomer Carl Sagan, but that grand statement can be broken-down into every constituent part of the human body–such as your teeth and bones.
Astronomers using the European Southern Observatory (ESO)‘s mighty Atacama Large Millimeter/submillimeter Array (ALMA) in Chile have detected fluorine in a distant star-forming galaxy 12 billion light-years away.
It’s the first time fluorine has been observed in a star-forming galaxy so early in the history of the Universe.
“We all know about fluorine because the toothpaste we use every day contains it in the form of fluoride,” said Maximilien Franco from the University of Hertfordshire in the UK, who led the new study, published today in Nature Astronomy.
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In a study published in Nucleic Acids Research, the team of cancer researcher Francis Rodier, an Université de Montréal professor, shows for the first time that cellular senescence, which occurs when aging cells stop dividing, is caused by irreversible damage to the genome rather than simply by telomere erosion.
This discovery goes against the scientific model most widely adopted in the last 15 years, which is based on one principle: telomeres, caps located at the ends of chromosomes whose purpose is to protect genetic information, erode with each cell division. When they get too short, they tell the cell to stop dividing, thus preventing damage to its DNA. Made dormant, the cell enters senescence.
For this model to be valid, the inactivation of a single telomere should be sufficient to activate the senescence program. Rodier’s laboratory and many others had already observed that several dysfunctional telomeres were necessary.
The antibody therapy, REGEN-COV, is currently authorized in the United States to treat people with mild-to-moderate COVID-19 and for prevention of infection in those exposed to infected individuals, and others at high risk of exposure in settings such as nursing homes or prisons. [USN: L4N2P640O]
The extended authorization could help boost sales of Regeneron’s antibody cocktail, in the face of competition from oral COVID-19 pills such as those being developed by Pfizer Inc (PFE.N) and Merck & Co (MRK.N).
Regeneron Pharmaceuticals Inc said on Monday a single dose of its antibody cocktail reduced the risk of contracting COVID-19 by 81.6% in a late-stage trial, in the two to eight months period following the drug’s administration.
One of the things that many people hate most about getting vaccinations and taking certain types of medication is needles. Any medication that has to be delivered intramuscular typically requires a needle and a skilled medical professional to administer it. However, that may change in the future with a new autonomous robot created by a company called Cobionix, founded at the University of Waterloo.
The autonomous robot utilizes the company’s Cobi platform to perform injections without using needles. Cobi is described as a versatile robotic platform that can be deployed rapidly and complete tasks completely autonomously. The robot was fitted with a needle-free injection system. It demonstrated the ability to deliver intramuscular injections to patients without needing needles and without supervision by a healthcare professional.
The robot developers believe that Cobi and solutions like it could help protect healthcare workers, reduce the cost of healthcare, and help improve patient outcomes. Researchers believe the autonomous design of the robot will dramatically reduce the requirements for vaccine clinics and could help deliver vaccines and other medications to remote populations with limited access to healthcare.
