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Scientists have developed artificial intelligence software that can create proteins that may be useful as vaccines, cancer treatments, or even tools for pulling carbon pollution out of the air.

This research, reported today in the journal Science, was led by the University of Washington School of Medicine and Harvard University. The article is titled “Scaffolding functional sites using deep learning.”

“The proteins we find in nature are amazing molecules, but designed proteins can do so much more,” said senior author David Baker, an HHMI Investigator and professor of biochemistry at UW Medicine. “In this work, we show that machine learning can be used to design proteins with a wide variety of functions.”

Sub-Saharan Africa could soon account for half the world’s cases of cancer in children unless the disease is prioritized through robust national plans, a study published in Lancet Oncology suggests.

Lead author, Wil Ngwa, from the Johns Hopkins Medicine, said that the high rate of people in Africa surviving infectious diseases could be a reason for surging cases of infection-related cancers such as Kaposi sarcoma, Burkitt lymphoma, Hodgkin lymphoma and hepatocellular carcinoma, and also embryonal cancers like retinoblastoma and nephroblastoma.

Another study, published in the journal Cancers, found close to 1.7 million children under 15 years of age with Human Immunodeficiency Virus (HIV) worldwide, a risk factor for cancer in children, 91% of them in sub-Saharan Africa. The researchers found that Kaposi sarcoma and lymphoma are the most common.

The U.S. Department of Justice seized roughly $500,000 in ransom payments that a medical center in Kansas paid to North Korean hackers last year, along with cryptocurrency used to launder the payments, Deputy Attorney General Lisa Monaco said Tuesday.

The hospital quickly paid the attackers, but also notified the FBI, “which was the right thing to do for both themselves and for future victims,” Monaco said in a speech at the International Conference on Cyber Security at Fordham University in New York City.

The notification enabled the FBI to trace the payment through the blockchain, an immutable public record of cryptocurrency transactions.

Going to the doctor might make you want to cry, and according to a new study, doctors could someday put those tears to good use. In ACS Nano, researchers report a nanomembrane system that harvests and purifies tiny blobs called exosomes from tears, allowing researchers to quickly analyze them for disease biomarkers. Dubbed iTEARS, the platform could enable more efficient and less invasive molecular diagnoses for many diseases and conditions, without relying solely on symptoms.

Diagnosing diseases often hinges on assessing a patient’s symptoms, which can be unobservable at early stages, or unreliably reported. Identifying molecular clues in samples from patients, such as specific proteins or genes from vesicular structures called exosomes, could improve the accuracy of diagnoses. However, current methods for isolating exosomes from these samples require long, complicated processing steps or large sample volumes. Tears are well-suited for sample collection because the fluid can be collected quickly and non-invasively, though only tiny amounts can be harvested at a time. So, Luke Lee, Fei Liu and colleagues wondered if a nanomembrane system, which they originally developed for isolating exosomes from urine and plasma, could allow them to quickly obtain these vesicles from tears and then analyze them for disease biomarkers.

The team modified their original system to handle the low volume of tears. The new system, called “Incorporated Tear Exosomes Analysis via Rapid-isolation System” (iTEARS), separated out exosomes in just 5 minutes by filtering tear solutions over nanoporous membranes with an oscillating pressure flow to reduce clogging. Proteins from the exosomes could be tagged with fluorescent probes while they were still on the device and then transferred to other instruments for further analysis. Nucleic acids were also extracted from the exosomes and analyzed.

Tokyo confirmed 20,401 new COVID-19 cases Wednesday, topping 20,000 for the first time since Feb. 5, while Osaka Prefecture reported a record high 21,976 infections, contributing to an unprecedented nationwide daily total of over 150,000 new cases.

Asked earlier in the day about prefectures reporting high case counts, Chief Cabinet Secretary Hirokazu Matsuno had reiterated that the central government would not be imposing any restrictions on people’s movements.