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Category: biotech/medical – Page 1,139

Cryo-electron microscopy captures structure of a protein pump

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts. It is caused by a mutation in the gene that codes for a specific protein involved in the transportation of calcium and manganese ions from the cell cytoplasm and into a sac-like organelle called the Golgi apparatus.

Scientists at Tohoku University, together with colleagues in Japan, have uncovered some aspects of this ’s structure that could help researchers understand how it works. The findings, published in the journal Science Advances, help build the foundations for research into finding treatments for Hailey-Hailey disease and other neurodegenerative conditions.

The protein the team studied is called secretory pathway Ca2+/Mn2+-ATPase, or SPCA for short. It is located in the Golgi apparatus, a cellular sac-like structure that plays a crucial role in protein quality control before they are released into cells. The Golgi apparatus also acts like a sort of calcium ion storage container. Calcium ions are vital for cell signaling processes and are important for proteins to function properly, so maintaining the right calcium ion balance inside cells is necessary for their day-to-day activities.

An ‘ecosystem’ of tools to boost machine learning-based design of metal–organic frameworks

A team of chemists and computer scientists from the Swiss Federal Institute of Technology Lausanne, the University of California and Institut des Sciences et Ingenierie Chimiques, Ecole, have developed an ecosystem of tools to boost machine-learning-based design of metal-organic frameworks.

In their study, reported in the journal ACS Central Science, Kevin Maik Jablonka, Andrew Rosen, Aditi Krishnapriyan and Berend Smit coded tools to convert data into machine learning inputs to create a system to boost machine-learning frameworks.

Reticular chemistry is the science of designing and synthesizing porous crystalline materials with certain predefined structures and properties (building blocks). These materials, known as (MOFs) have applications in gas storage, separation, catalysis, sensing and drug delivery.

The Rise Of Genetic Engineering | Gene-Editing | Documentary

Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.

The Rise Of Genetic Engineering (2022)
Writers: Kyle McCabe, Christopher Webb Young.
Stars: Rodolphe Barrangou, George Church, Mary Beth Dallas.
Genre: Documentary.
Country: United States.
Language: English.
Release Date: August 24, 2022 (United States)

Synopsis:
Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.

Methods like this allow scientists to alter and ‘re-program’ the genetics of living organisms.

This episode shows scientists at large using gene-editing technologies to revolutionize the food supply chain, bolstering food crops to prevent famines, and even speed up reforestation efforts that will reverse global warming. Genetic Engineering in farm animals is helping scientists to ‘select’ desirable traits, like physical features and gender. Incredibly, one scientist is using gene-editing technologies to resurrect the DNA of extinct species, like the Wooly Mammoth!

Despite some public concern, gene-editing is definitely a cause for hope in the fight against genetic disorders in humans. It’s already reversing a type of congenital blindness in children. And with the hyper-precision afforded by PRIME editing being prepared for clinical trials, a much more hopeful world will be revealed for families in the future.

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DNA Double Helix Splits Due to Invasive Nature of Unzipping Process

Scientists had a hard time reconstructing how complex molecular parts are being held together. However, that was before SISSA’s Cristian Micheletti and his team studied how the DNA double helix unzips when translocated at high velocity through a nanopore.

DNA Double Helix’s Unzipping

DNA has a double helix structure because it consists of two spiral chains of deoxyribonucleic acid. Its shape is reminiscent of a spiral staircase.

MIT is testing light and sound to combat Alzheimer’s

Our brains aren’t limited to producing just one type of brain wave at a time, but usually, one type is dominant, and the type it is can often be linked to your level of alertness: delta waves may dominate when you sleep, while gamma waves might dominate when you concentrate intensely.

The idea: Researchers have previously observed that people with Alzheimer’s — a devastating neurological disease affecting more than 6 million people in the US alone — may have weaker and less in-sync gamma waves than people who don’t have the disease.

In a series of past studies, MIT researchers demonstrated a deceptively simple way to increase the power and synchronization of these waves in mouse models of Alzheimer’s: expose the animals to lights flickering and/or sounds clicking at a frequency of 40 Hz.

Organoids — growing mini BRAINS

Organoids are an incredible tool for research into the brain. Cerebral organoids are created by growing human stem cells in a bioreactor. They might be the key to unlocking the answers to many of our questions about the brain. We explain how they’re made and some of the discoveries they’ve helped with so far!
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✍ Script by Duranka Perera (https://www.durankaperera.com/)
✍ Thumb by “Broken” Bran — https://twitter.com/BranGSmith.
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Support us on Patreon: https://www.patreon.com/Brainbook_
Thank you to our supporters:

Morag Forbes.
Patrick Kohl.
Ronald Coleman Dees.
Alex Rofini.
Helen Whitley.
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Discover more on our website.
https://www.brainbookcharity.org.
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What if You Give a Rat Human Brain Cells? You Can Control Its Behavior… — YouTube

Scientists transplanted human cerebral organoids (“minibrains”) into rats, to better study brain disorders. The neurons grown in vivo looked more like mature human brain cells than those grown in vitro, and they made better models of Timothy syndrome. The human minibrains formed deep connections with the rat brains, received sensory information, and drove the rat’s behavior.

More on how minibrains are grown and used, and the issue of organoid consciousness: https://www.youtube.com/watch?v=u6FGq7_t3Eo.

On the topic of organoid sentience and playing pong: https://www.youtube.com/watch?v=67r7fDRBlNc.

Support the channel: https://www.patreon.com/ihmcurious.

Sitcom music by John Bartmann: https://johnbartmann.com

Growing Mini-Brains in a Lab: Cerebral Organoids Could Save Your Life, But Has Science Gone Too Far?

Chapters:
0:00 Intro.
0:43 Growing Organoids.
2:57 Minibrains in Science & Medicine.
4:46 Giving Minibrains Psychedelics.
5:26 Minibrains With Eyes.
6:30 Can Minibrains Feel?
7:22 Looking For Consciousness.
9:03 The Future of Minibrain Research.
10:47 Human Minibrains Grafted Onto Mice.
12:10 What’s Next?

Videography by Island Fox Media.

Sound by Kutan Katas.

Patreon: https://www.patreon.com/IhmCurious.

Twitter: https://twitter.com/IhmCurious.

Music.

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