Scientists identify an autoantibody that may cause schizophrenia in some individuals. Researchers from Tokyo Medical and Dental University (TMDU) have discovered that some people with schizophrenia have autoantibodies—which are made by the immune system and recognize the body’s own proteins, rat…
A team of scientists in the Physical Intelligence Department at the Max Planck Institute for Intelligent Systems have combined robotics with biology by equipping E. coli bacteria with artificial components to construct biohybrid microrobots. First, as can be seen in Figure 1, the team attached several nanoliposomes to each bacterium. On their outer circle, these spherical-shaped carriers enclose a material (ICG, green particles) that melts when illuminated by near infrared light. Further towards the middle, inside the aqueous core, the liposomes encapsulate water soluble chemotherapeutic drug molecules (DOX).
The second component the researchers attached to the bacterium is magnetic nanoparticles. When exposed to a magnetic field, the iron oxide particles serve as an on-top booster to this already highly motile microorganism. In this way, it is easier to control the swimming of bacteria —an improved design toward an in vivo application. Meanwhile, the rope binding the liposomes and magnetic particles to the bacterium is a very stable and hard to break streptavidin and biotin complex, which was developed a few years prior and reported in a Nature article, and comes in useful when constructing biohybrid microrobots.
E. coli bacteria are fast and versatile swimmers that can navigate through material ranging from liquids to highly viscous tissues. But that is not all, they also have highly advanced sensing capabilities. Bacteria are drawn to chemical gradients such as low oxygen levels or high acidity—both prevalent near tumor tissue. Treating cancer by injecting bacteria in proximity is known as bacteria mediated tumor therapy. The microorganisms flow to where the tumor is located, grow there and in this way activate the immune system of patients. Bacteria mediated tumor therapy has been a therapeutic approach for more than a century.
Surveillance, Preparedness & Health Security In Critical Disease Emergencies — Dr. Rosamund Lewis, MD, Head, WHO Smallpox Secretariat, Technical Lead for Monkeypox.
Dr. Rosamund Lewis, MD, is Head, WHO Smallpox Secretariat, Emerging Diseases and Zoonoses Unit, World Health Emergencies Programme, at the World Health Organization in Geneva, Switzerland, leading on emergency preparedness and advising on health security for the agency in this very critical domain, including as technical lead for Monkeypox. She also holds an appointment as Adjunct Professor in the School of Epidemiology and Public Health, University of Ottawa.
Previous to this role, Dr. Lewis joined the WHO COVID-19 response team as the health sciences lead for management of infodemics.
In cancer research, it all comes down to a single cell.
Over the last decade, cancer researchers have homed in on the fact that an individual cell from a tumor can be used to perform molecular analyses that reveal important clues about how the cancer developed, how it spreads and how it may be targeted.
With this in mind, a team of researchers at Brown University has developed an advanced way to isolate single cells from complex tissues. In a study published in Scientific Reports, they show how the approach not only results in high-quality, intact single cells, but is also superior to standard isolation methods in terms of labor, cost and efficiency.
The term ‘type 3 diabetes’ has been used by some to describe Alzheimer’s disease.
While most of us are familiar with type 1 and type 2 diabetes, you may not have come across the term ‘type 3 diabetes’ before. First things first, this is not to be confused with type 3c diabetes, which is something else entirely. It is, however, related to insulin resistance in the brain.
Being diagnosed as insulin resistant generally means that someone is either prebiabetic or has type 2 diabetes. But scientists have proposed that it can also result in the brain’s neurons lacking glucose, which is needed for proper function, and this can lead to symptoms of Alzheimer’s disease.
I share this revealing interview given by Liz Parrish, “Patient Zero” in biological rejuvenation, to a journalist in Madrid, Spain. It took place in July 10, 2022 and lasts 20 minutes.
During the interview Liz speaks in English. However, the journalist, whose name is María Zabay, speaks mostly in Spanish.
Don’t miss it because Liz says things that most people don’t know about her and her company BioViva Sciences.
June 29 (Reuters) — Germany’s BioNTech (22UAy. DE), Pfizer’s (PFE.N) partner in COVID-19 vaccines, said the two companies would start tests on humans of next-generation shots that protect against a wide variety of coronaviruses in the second half of the year.
Their experimental work on shots that go beyond the current approach include T-cell-enhancing shots, designed to primarily protect against severe disease if the virus becomes more dangerous, and pan-coronavirus shots that protect against the broader family of viruses and its mutations.
In presentation slides posted on BioNTech’s website for its investor day, the German biotech firm said its aim was to “provide durable variant protection”.
Text-to-image generation is the hot algorithmic process right now, with OpenAI’s Craiyon (formerly DALL-E mini) and Google’s Imagen AIs unleashing tidal waves of wonderfully weird procedurally generated art synthesized from human and computer imaginations. On Tuesday, Meta revealed that it too has developed an AI image generation engine, one that it hopes will help to build immersive worlds in the Metaverse and create high digital art.
A lot of work into creating an image based on just the phrase, “there’s a horse in the hospital,” when using a generation AI. First the phrase itself is fed through a transformer model, a neural network that parses the words of the sentence and develops a contextual understanding of their relationship to one another. Once it gets the gist of what the user is describing, the AI will synthesize a new image using a set of GANs (generative adversarial networks).
Thanks to efforts in recent years to train ML models on increasingly expandisve, high-definition image sets with well-curated text descriptions, today’s state-of-the-art AIs can create photorealistic images of most whatever nonsense you feed them. The specific creation process differs between AIs.
Patients undergo interventions to achieve a ‘normal’ brain temperature; a parameter that remains undefined for humans. The profound sensitivity of neuronal function to temperature implies the brain should be isothermal, but observations from patients and non-human primates suggest significant spatiotemporal variation. We aimed to determine the clinical relevance of brain temperature in patients by establishing how much it varies in healthy adults.
We retrospectively screened data for all patients recruited to the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) High Resolution Intensive Care Unit Sub-Study. Only patients with direct brain temperature measurements and without targeted temperature management were included. To interpret patient analyses, we prospectively recruited 40 healthy adults (20 males, 20 females, 20–40 years) for brain thermometry using magnetic resonance spectroscopy. Participants were scanned in the morning, afternoon, and late evening of a single day.
In patients (n = 114), brain temperature ranged from 32.6 to 42.3°C and mean brain temperature (38.5 ± 0.8°C) exceeded body temperature (37.5 ± 0.5°C, P 0.0001). Of 100 patients eligible for brain temperature rhythm analysis, 25 displayed a daily rhythm, and the brain temperature range decreased in older patients (P = 0.018). In healthy participants, brain temperature ranged from 36.1 to 40.9°C; mean brain temperature (38.5 ± 0.4°C) exceeded oral temperature (36.0 ± 0.5°C) and was 0.36°C higher in luteal females relative to follicular females and males (P = 0.0006 and P 0.0001, respectively). Temperature increased with age, most notably in deep brain regions (0.6°C over 20 years, P = 0.0002), and varied spatially by 2.41 ± 0.46°C with highest temperatures in the thalamus. Brain temperature varied by time of day, especially in deep regions (0.86°C, P = 0.0001), and was lowest at night. From the healthy data we built HEATWAVE—a 4D map of human brain temperature.
A new computer algorithm developed by the University of Toronto’s Parham Aarabi can store and recall information strategically—just like our brains.
The associate professor in the Edward S. Rogers Sr. department of electrical and computer engineering, in the Faculty of Applied Science & Engineering, has also created an experimental tool that leverages the new algorithm to help people with memory loss.
“Most people think of AI as more robot than human,” says Aarabi, whose framework is explored in a paper being presented this week at the IEEE Engineering in Medicine and Biology Society Conference in Glasgow. “I think that needs to change.”
