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Unprecedented 3D Synapse Imaging to Combat Neurodegenerative Diseases

Summary: Researchers developed one of the most comprehensive 3D models of the synapse, the neuron juncture crucial for intercellular communication. This breakthrough allows an unprecedented view of the complex interactions between individual cells at the synapse, offering fresh insights into neurodegenerative diseases such as Huntington’s disease and schizophrenia.

The team used this novel approach to compare healthy mice brains to those with the Huntington’s mutant gene, revealing structural flaws potentially disrupting cellular communication. The researchers believe this technique could significantly advance our understanding of various neurodegenerative and neuropsychiatric diseases.

Vitamin B6 Didn’t Impact NAD (Test Results)

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New neuroscience research sheds light on why anxiety tends to diminish with age

As people get older, they tend to have lower levels of anxiety. But why? A new brain imaging study has found that older individuals are faster at recognizing and responding to negative emotions. The findings, published NeuroImage, go against the idea that older adults are less engaged with negative emotions due to cognitive decline or that they are better at regulating negative emotions. Instead, the results suggest that older adults may develop a more automatic way of processing negative emotions.

The study aimed to investigate the relationship between aging, trait anxiety, and changes in cognitive and affective functions. The researchers were motivated by previous findings that older adults tend to have lower susceptibility to anxiety disorders compared to younger and middle-aged adults. However, it was not clear how age-related changes in anxiety symptoms, such as worry and somatic symptoms, were related to changes in cognitive and affective processes.

“We are interested in emotion dysfunction in early dementia, including those people with subjective complaints of memory problem and mild cognitive impairment,” said study author Chiang-shan Ray Li, a professor of psychiatry and neuroscience at Yale University School of Medicine.

Eliminating Death Doesn’t Mean Life Will Get Boring

In my new Newsweek Op-Ed, I tackle a primary issue many people have with trying to stop aging and death via science. Hopefully this philosophical argument will allow more resources & support into the life extension field:


Philosophers often say if humans didn’t die, we’d be bored out of our minds. This idea, called temporal scarcity, argues the finitude of death is what makes life worth living. Transhumanists, whose most urgent goal is to use science to overcome biological death, emphatically disagree.

For decades, the question of temporal scarcity has been debated and analyzed in essays and books. But an original idea transhumanists are putting forth is reinvigorating the debate. It doesn’t discount temporal scarcity in biological humans; it discounts it in what humans will likely become in the future—cyborgs and digitized consciousnesses.

The traditional temporal scarcity argument against immortality imagines the human being remaining biologically the same as it has for tens of thousands of years. Yet the human race is already augmenting the human body with radical technology. Globally, over 200,000 people already have brain implants, and Silicon Valley companies like Elon Musk’s Neuralink are working on trying to get millions of us to become cyborgs.

A growing number of experts even believe by the end of the century, humans will likely have the ability to upload the brain and its consciousness into a computer. In the process, digitized people will overcome biological death and engage in far more complex ways of being, including grand new designs of consciousness and selfhood.

Chinese researchers claim they can synthesize tonal speech using neural cues

The research is a result of observations from awake language mapping during brain tumor surgery.

A team of Chinese researchers has developed a way to artificially produce speech, also known as speech synthesis, using cues from neural brain activity.

According to the South China Morning Post, the researchers claim that they have a mind-reading machine that is capable of turning human thought into spoken Mandarin.

Psychedelics Unlock Learning Windows in the Brain

Summary: Researchers discovered a unique property of psychedelic drugs: their ability to reopen “critical periods” in the brain, times when the brain is highly susceptible to environmental learning signals. These periods, usually associated with skills development like language learning, are reopened by psychedelics for different lengths of time.

This breakthrough in understanding psychedelic drug function may have therapeutic implications for conditions like stroke and deafness. Further, it uncovers novel molecular mechanisms influenced by psychedelics.

Video Game Algorithm Unlocks Molecular Mysteries of Brain Cells

Summary: Researchers leveraged a tracking algorithm from video games to study molecules’ behavior within live brain cells.

They adapted the fast and accurate algorithm used to track bullets in combat games for use in super-resolution microscopy. The innovative approach enables scientists to observe how molecules cluster together to perform specific functions in space and time within the brain cells.

The data obtained could shed light on molecular functions’ disruption during aging and disease.

Healthcare Robot with ‘Sense of Touch’ Could Reduce Infection Spread

A first-of-its-kind robot which gives clinicians the ability to ‘feel’ patients remotely has been launched as part of a Finnish hospital pilot by deep tech robotics company Touchlab, a new tenant of the world-leading centre for robotics and artificial intelligence the National Robotarium.

Controlled by operators wearing an electronic haptic glove, the Välkky telerobot is equipped with the most advanced electronic skin (e-skin) technology ever developed to transfer a sense of touch from its robotic hand to users. E-skin is a material which is made up of single or multiple ultra-thin force sensors to transmit tactile sensations like pressure, vibration or motion from one source to another in real-time.

The 3-month pilot at Laakso Hospital in Helsinki, Finland will see a team of purpose-trained nurses explore how robotics systems can help deliver care, reduce workload and prevent the spread of infections or diseases. The pilot at Laakso Hospital is coordinated by Forum Virium Helsinki, an innovation company for the City of Helsinki. The research is part of a wider €7 billion project aimed at developing the most advanced hospital in Europe, due to be completed in 2028.

How often should I get a colonoscopy?

Getting a colonoscopy is important to screen for colorectal cancer. But how often you should get a colonoscopy depends on several different factors.

Current guidelines suggest that you get your first colonoscopy at age 45 if you are at average risk for colorectal cancer. If no polyps are found, you won’t need another colonoscopy for another 10 years. But in certain situations, you may need a colonoscopy more often.

We spoke with gastroenterologist Mazen Alasadi, M.D., to learn more.

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