Lifeboat Foundation

Scientists transplant a pig’s liver into a brain-dead patient with no organ rejection. This may solve the problem of scarcity of donors.

The immune system is comprised of two separate responses referred to as either innate or adaptive immunity. Both work in collaboration to elicit protection against anything the body encounters as ‘foreign’. In many cases foreign pathogens that enter the body are recognized by the innate immune system first which then activate adaptive immunity. The innate immune system uses many broad, non-specific cells to detect anything that might cause harm to the body. These cells initiate inflammation and the overall immune response. The adaptive immune system comes second and is more specific to the invading pathogen. Adaptive immune cells can not only help lyse or kill the invaders, but also generate cells to ‘remember’ that pathogen in the future. This is a common phenomenon that occurs when we overcome an illness and is known as immunological memory. Vaccine biology is based on this concept that we will generate ‘memory cells’ in response to attenuated viruses.

The study of immunity and how our body fights off disease is a progressively growing field. Currently, scientists know many of the key players that drive this immunological memory. However, researchers and physicians are working together to better understand this process and how to generate more effective treatments for various diseases. An exciting article in Nature, published by Dr. Francisco J. Quintana and others, demonstrate that a glial cell can generate immunological memory. Quintana, an investigator at Brigham and Women’s Hospital, and his team study different signaling pathways associated with immune activity to identify novel therapeutic treatments and biomarkers to measure treatment efficacy. The glial cell Quintana and his team found to aid in immunity is known as an astrocyte, which is a key cell within the central nervous system (CNS). Astrocytes help promote synapse formation, clear excess neurotransmitters, and maintain the blood-brain barrier.

For the first time astrocytes have been connected to obtain memory-like properties and aid in immunity. The team used multiple models to demonstrate that astrocytes can remember previous interactions with immune cells. Not only did this function improve response time to infection but induced a stronger immune response when re-exposed to the same disease. Due to similarities in memory formation, Quintana and others refer to this process as ‘astrocyte immune memory’. Interestingly, due to astrocytes long lifespan, these cells could provide insight into chronic neurologic disorders.

A map of mouse development from conception to birth tracks 12.4 million cells at single-cell resolution as they mature into organs and other tissues.

The cyberattack on Change Healthcare last month should serve as a wake-up call for the health care industry, which needs to focus on securing its infrastructure, says Kevin Fu, a Northeastern University professor of electrical and computer engineering and cybersecurity adviser to the White House.

The human brain, it turns out, can be surprisingly resistant to the ravages of time.

A new study has cataloged human brains that have been found on the archaeological record around the world and discovered that this remarkable organ resists decomposition far more than we thought – even when the rest of the body’s soft tissues have completely melted away.

Led by molecular taphonomist Alexandra Morton-Hayward of the University of Oxford, a team of scientists has identified more than 4,400 preserved human brains, dating back as far as 12,000 years ago. The results contradict previous evidence that the human brain is among the first organs to decay after death.

A publication in Nature reports the data release of around 245,000 clinical-grade whole-genome sequences as part of the NIH’s All of Us Research Programme. Several companion papers highlight the value of better capturing global genomic diversity.

Scientists have discovered that, when a DNA-reading enzyme moves backwards along a gene, it may do so to help control when the gene is turned on.

Our immune system is talented at telling the difference between the chemistry of our own body and that of an invading pathogen. When it malfunctions, our body can become host to an intense civil war.

Scientists are keen to understand this in more detail, and a newly identified ‘switch’ that deactivates a sensor of foreign DNA may provide important insight.

A key part of this discovery, made by a team from the Swiss Federal Institute of Technology Lausanne, is an enzyme called cyclic GMP-AMP synthase (cGAS).

The best-known byproduct of ultrasound—so named because its frequencies exceed the range of the human ear—is, in fact, not audio but visual: 2D imagery, often of a fetus maturing in the womb. But ultrasound has also found a place in other corners of the medical realm, from assessing blood flow to examining suspicious lumps and diagnosing disease.