Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer’s and similar diseases, before extensive brain cell death and dementia set in. A study published in Alzheimer’s & Dementia shows up to a six-month window in which disease progress could be tracked and treatments tested in rhesus macaques.
Chinese scientists have engineered a solution by which they could bypass natural plant gene inheritance. They aim to deploy a CRISPR-based gene editing system to help the transmission of preferred genes even when they aren’t suitable for a plant.
The scientists devised a system that would use both a toxin and an antidote which would directly affect the male plant germline. Through this process, the researchers could overcome the natural Mendelian transmission rate. This can help increase the gene transmission rates up to 99% over two generations.
This study identifies a small molecule (TAC) that restores physiological levels of TERT throughout aged tissues, resulting in the rejuvenation of multiple tissues. Specifically, TAC administration in very aged mice alleviates multiple aging hallmarks such as cellular senescence and systemic inflammation, promotes new neuron formation with improved cognitive ability, enhances neuromuscular function, and is well tolerated with no evidence of toxicity.
A little scifi sold again as near future situation.
Introducing Cognify, the prison of the future. This facility is designed to treat criminals like patients. Instead of spending years in an actual prison cell, prisoners could finish their sentence here in just a few minutes. Cognify could someday create and implant artificial memories directly into the prisoner’s brain. It could offer a new approach to criminal rehabilitation, transforming how society deals with offenders by focusing on rehabilitation rather than punishment. #Science #Technology #Research #NeuroScience #psychology.
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Menthol detection predates the sensation of cold, indicating separate activation mechanisms that can be distinguished. This differentiation opens possibilities for novel pain treatments that avoid unwanted thermal side effects.
Millions of people around the globe suffer from chronic pain, and many existing treatments depend on opioids, which have significant addiction and overdose risks. Developing non-addictive pain relief options could transform how pain is managed. Recent research focusing on a human protein that controls cold sensations are paving the way for new pain medications. These innovative drugs aim to manage pain without altering body temperature or posing addiction risks.
A new study published in Science Advances on June 21, led by Wade Van Horn, professor in Arizona State University’s School of Molecular Sciences and Biodesign Center for Personalized Diagnostics, has uncovered new insights into the main human cold and menthol sensor TRPM8 (transient receptor potential melastatin 8). Using techniques from many fields like biochemistry and biophysics, their study revealed that it was a chemical sensor before it became a cold temperature sensor.
A recent study at MIT has debunked the effectiveness of a new MRI method called DIANA, which was initially thought to directly detect neural activity.
Instead, the signals detected were found to be artifacts produced by the imaging process itself, highlighting the complexities and challenges in developing accurate neuroimaging techniques.
According to scientists at MIT’s McGovern Institute for Brain Research, a new way of imaging the brain with magnetic resonance imaging (MRI) does not directly detect neural activity as originally reported.
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Scientists at Kyoto University Hospital will conduct the first human trial of the drug from September 2024 to August 2025. In tests on ferrets and mice, the drug worked with no notable side effects, Popular Mechanics reported.
The drug will be used on 30 men between 30–64 who are missing at least one molar. From there, researchers will expand the study to those with partial edentulism, or those missing one to five permanent teeth.
Centenarians have become the fastest-growing demographic group in the world, with numbers approximately doubling every 10 years since the 1970s.
Many researchers have sought out the factors and contributors that determine a long and healthy life. The dissolution isn’t new either, with Plato and Aristotle writing about the ageing process over 2,300 years ago.
Understanding what is behind living a longer life involves unravelling the complex interplay of genetic predisposition and lifestyle factors and how they interact.