We take a look at and why some researchers think it could be useful in combating aging.
Rapamycin is a macrolide, a class of antibiotic that includes erythromycin, roxithromycin, azithromycin, and clarithromycin. exhibits potent antitumor and immunosuppressive activity.
Where is found?
Aging is characterized by changes in cellular identity and function over time. This process is driven by changes in chromatin factor localization during DNA break repair, which alters the epigenome and advances the epigenetic clock. Expression of a subset of Yamanka factors, OSK, can reverse these changes and modulate aging.
When genes are activated and expressed, they show patterns in cells that are similar in type and function across tissues and organs. Discovering these patterns improves our understanding of cells—which has implications for unveiling disease mechanisms.
The advent of spatial transcriptomics technologies has allowed researchers to observe gene expression in their spatial context across entire tissue samples. But new computational methods are needed to make sense of this data and help identify and understand these gene expression patterns.
A research team led by Jian Ma, the Ray and Stephanie Lane Professor of Computational Biology in Carnegie Mellon University’s School of Computer Science, has developed a machine learning tool to fill this gap. Their paper on the method, called SPICEMIX, appeared as the cover story in the most recent issue of Nature Genetics.
I made this video with the help of Artificial Intelligence to prove the point Terence McKenna makes in this video that AI will surpass the human production in all the levels.
What did AI tools make?
- Tuning the audio quality to make it look like a podcast record, even though the audio was recorded with a low quality hand microphone in a party in 1998.
- Creating a realistic HD picture of Terence McKenna and tuning the color level, with background.
AUTHOR :
Terence Kemp McKenna (November 16, 1946 – April 3, 2000) was an American ethnobotanist and mystic who advocated the responsible use of naturally occurring psychedelic plants. He spoke and wrote about a variety of subjects, including psychedelic drugs, plant-based entheogens, shamanism, metaphysics, alchemy, language, philosophy, culture, technology, environmentalism, and the theoretical origins of human consciousness. He was called the “Timothy Leary of the ‘90s”, “one of the leading authorities on the ontological foundations of shamanism”, and the “intellectual voice of rave culture”.
McKenna formulated a concept about the nature of time based on fractal patterns he claimed to have discovered in the I Ching, which he called novelty theory, proposing that this predicted the end of time, and a transition of consciousness in the year 2012. His promotion of novelty theory and its connection to the Maya calendar is credited as one of the factors leading to the widespread beliefs about the 2012 phenomenon. Novelty theory is considered pseudoscience.
https://share.epidemicsound.com/xr9f5b.
OUR ADDED-VALUE :
Technology and medicine are becoming more wondrous, and now a new drug will be developed that will prevent people from freezing.
Posted in biotech/medical
A chronic cough is a cough that lasts eight weeks or longer in adults, or four weeks in children.
A chronic cough is more than just an annoyance. A chronic cough can interrupt your sleep and leave you feeling exhausted. Severe cases of chronic cough can cause vomiting, lightheadedness and even rib fractures.
While it can sometimes be difficult to pinpoint the problem that’s triggering a chronic cough, the most common causes are tobacco use, postnasal drip, asthma and acid reflux. Fortunately, chronic cough typically disappears once the underlying problem is treated.
Leading The Global Fight Against Antimicrobial Resistance (AMR) — Dr. Haileyesus Getahun, MD, MPH, Ph.D., Director of AMR Global Coordination, World Health Organization (WHO)
Dr. Haileyesus Getahun, MD, MPH, Ph.D. is Director of AMR (Antimicrobial Resistance) Global Coordination at the World Health Organization (WHO) and the Quadripartite (FAO/UNEP/WHO/WOAH) Joint Secretariat on Antimicrobial Resistance. (https://www.who.int/about/people/biography/dr-haileyesus-getahun)
Antimicrobial resistance (AMR) threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses and fungi. AMR occurs when bacteria, viruses, fungi and parasites change over time and no longer respond to medicines making infections harder to treat and increasing the risk of disease spread, severe illness and death. As a result, the medicines become ineffective and infections persist in the body, increasing the risk of spread to others. Over 1.27 million deaths worldwide were attributed to AMR infections in 2019. Antimicrobials — including antibiotics, antivirals, antifungals and antiparasitics — are medicines used to prevent and treat infections in humans, animals and plants. Microorganisms that develop antimicrobial resistance are sometimes referred to as “superbugs”.
Dr. Getahun coordinates the global One Health multi-sectoral response to AMR across the human, animal, plant, food, feed and environment sectors; directs the Secretariat of the Global Leaders Group on AMR (https://www.amrleaders.org) currently co-chaired by Their Excellencies Prime Minister of Barbados and Bangladesh; facilitates the research and development agenda through priority setting and gap analysis, and provides policy and programmatic guidance to nurture and scale up evidence-based interventions to enhance antimicrobial stewardship activities, awareness and behavioral change across all sectors.
Dr. Getahun was formerly the Director of the Secretariat of the United Nations Interagency Coordination Group on Antimicrobial Resistance (IACG) which was established by the UN Secretary General and released the 2019 ground-breaking report on how to respond to the global AMR crisis. Before that he worked in the Global TB Program of WHO leading its work on TB/HIV and community care.
The rebooting came in the form of a gene therapy involving three genes that instruct cells to reprogram themselves—in the case of the mice, the instructions guided the cells to restart the epigenetic changes that defined their identity as, for example, kidney and skin cells, two cell types that are prone to the effects of aging. These genes came from the suite of so-called Yamanaka stem cells factors—a set of four genes that Nobel scientist Shinya Yamanaka in 2006 discovered can turn back the clock on adult cells to their embryonic, stem cell state so they can start their development, or differentiation process, all over again. Sinclair didn’t want to completely erase the cells’ epigenetic history, just reboot it enough to reset the epigenetic instructions. Using three of the four factors turned back the clock about 57%, enough to make the mice youthful again.
“We’re not making stem cells, but turning back the clock so they can regain their identity,” says Sinclair. “I’ve been really surprised by how universally it works. We haven’t found a cell type yet that we can’t age forward and backward.”
Rejuvenating cells in mice is one thing, but will the process work in humans? That’s Sinclair’s next step, and his team is already testing the system in non-human primates. The researchers are attaching a biological switch that would allow them to turn the clock on and off by tying the activation of the reprogramming genes to an antibiotic, doxycycline. Giving the animals doxycycline would start reversing the clock, and stopping the drug would halt the process. Sinclair is currently lab-testing the system with human neurons, skin, and fibroblast cells, which contribute to connective tissue.
Summary: Researchers develop a novel tool that allows for the study of the communication of microbes in the gastrointestinal tract and the brain.
Source: Baylor College of Medicine.
In the past decade, researchers have begun to appreciate the importance of a two-way communication that occurs between microbes in the gastrointestinal tract and the brain, known as the gut–brain axis.
𝐁𝐫𝐞𝐚𝐤𝐭𝐡𝐫𝐨𝐮𝐠𝐡!
𝐍𝐞𝐮𝐫𝐨𝐬𝐜𝐢𝐞𝐧𝐭𝐢𝐬𝐭𝐬 𝐬𝐨𝐥𝐯𝐞 𝐦𝐲𝐬𝐭𝐞𝐫𝐢𝐞𝐬 𝐚𝐛𝐨𝐮𝐭 𝐥𝐞𝐚𝐝𝐢𝐧𝐠 𝐛𝐢𝐨𝐦𝐚𝐫𝐤𝐞𝐫 𝐟𝐨𝐫 𝐀𝐥𝐳𝐡𝐞𝐢𝐦𝐞𝐫’𝐬
𝙐𝙣𝙞𝙫𝙚𝙧𝙨𝙞𝙩𝙮 𝙤𝙛 𝙑𝙞𝙧𝙜𝙞𝙣𝙞𝙖 𝙣𝙚𝙪𝙧𝙤𝙨𝙘𝙞𝙚𝙣𝙩𝙞𝙨𝙩𝙨 𝙝𝙖𝙫𝙚 𝙧𝙚𝙫𝙚𝙖𝙡𝙚𝙙 𝙝𝙤𝙬 𝙖 𝙩𝙤𝙭𝙞𝙘 𝙛𝙤𝙧𝙢 𝙤𝙛 𝙩𝙖𝙪 𝙥𝙧𝙤𝙩𝙚𝙞𝙣, 𝙣𝙤𝙩𝙤𝙧𝙞𝙤𝙪𝙨 𝙛𝙤𝙧 𝙛𝙤𝙧𝙢𝙞𝙣𝙜 𝙩𝙖𝙣𝙜𝙡𝙚𝙨 𝙞𝙣 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣𝙨 𝙤𝙛 𝙥𝙚𝙤𝙥𝙡𝙚 𝙬𝙞𝙩𝙝 𝘼𝙡𝙯𝙝𝙚𝙞𝙢𝙚𝙧’𝙨 𝙙𝙞𝙨𝙚𝙖𝙨𝙚 𝙖𝙣𝙙 𝙨𝙚𝙫𝙚𝙧𝙖𝙡 𝙤𝙩𝙝𝙚𝙧 𝙣𝙚𝙪𝙧𝙤𝙙𝙚𝙜𝙚𝙣𝙚𝙧𝙖𝙩𝙞𝙫𝙚 𝙙𝙞𝙨𝙤𝙧𝙙𝙚𝙧𝙨, 𝙨𝙥𝙧𝙚𝙖𝙙𝙨 𝙩𝙝𝙧𝙤𝙪𝙜𝙝 𝙩𝙝𝙚 𝙗𝙧𝙖𝙞𝙣 𝙖𝙨 𝙩𝙝𝙚 𝙙𝙞𝙨𝙚𝙖𝙨𝙚 𝙥𝙧𝙤𝙜𝙧𝙚𝙨𝙨𝙚𝙨.
The new discovery advances the battle against the disease, which strikes 1 in 9 people over age 65.
