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Category: biotech/medical – Page 1014

The biotech platform that is leveraging one of the cornerstones of evolution – mitochondria.

Mitochondria play a crucial role in the aging process, activating factors and metabolic pathways involved in longevity. Their dysfunction impacts on both lifespan and healthspan, and whilst they have been identified as disease targets for some time, mitochondria have proven difficult to treat.

The founders of cellvie wondered if it were possible, as they put it, to leverage one of the cornerstones of evolution – to replace and augment damaged mitochondria. And so, the concept of Therapeutic Mitochondria Transplantation was born. TMT holds the potential of sustainably affecting mitochondria function, and reinvigorating or amplifying the cellular energy metabolism – and having raised $5 million in Kizoo-led seed funding, cellvie is on the way to turning that possibility into a reality.

Dr Alex Schueller, Cellvie’s CEO, will be speaking at Berlin’s Rejuvenation Startup Summit (14−15 October 2022), as part of an all-star line-up that includes Michael Greve, Eric Verdin, Brian Kennedy, Michael Sidler, Christian Angermayer and our own Phil Newman. Hosted by the Forever Healthy Foundation, this vibrant networking event aims to accelerate the development of the rejuvenation biotech industry.

Continue reading “Unlocking the power of cell-derived medicines with Dr Alex Schueller, Cellvie’s CEO” | >

With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery will help us understand aging and disease.

Physics is not the first scientific discipline that springs to mind at the mention of DNA. But John van Noort from the Leiden Institute of Physics (LION) is one of the scientists who found the new DNA structure. A biophysicist, he uses methods from physics for biological experiments. This also caught the attention of biologists from Nanyan Technological University in Singapore. They asked him to help study the DNA structure of . They have published the results in Nature.

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To begin with, it will only run at a fraction of its eventual three-quadrillion-watt maximum output.

A laser at the University of Michigan, which is set to be the most powerful in the United States, is preparing to send its first laser pulses into an experimental target, a press statement explains.

The laser, named the Zetawatt-Equivalent Ultrashort pulse laser System, or Zeus, will be used to investigate quantum physics as well as outer space. It is hoped studies using the laser will also help to build new technologies in electronics and medicine.

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Only two of the top 10 billionaires registered gains.

The world’s top richest people collectively lost $50 billion of their personal fortune as the New York Stock Exchange slumped on Tuesday amidst fears of rising inflation and looming inflation. Elon Musk, Jeff Bezos, Warren Buffet, Google Guys, nobody was spared as prices of stock held by them tumbled, Market Insider.

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Even as most people struggled to balance their work and life during the pandemic, the world’s top billionaires were struck gold and saw their fortunes soar. According to a CBS report in 2021, the first year of the pandemic gave a $4 trillion boost to the billionaires’ wealth, raising the call for a “wealth tax.”

Continue reading “Tech billionaires lost billion as stock prices tumbled on Tuesday” | >

In many cases, medicine has found ways to treat the symptoms of these degenerative conditions – such as using analgesics to alleviate osteoarthritis pain or corrective lenses or surgery to improve vision. But medicine still has not found a way to cure the underlying diseases.

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Biotech start-up Pretzel Therapeutics launched Monday with $72.5 million in Series A financing to develop novel, mitochondria-based therapies for rare genetic disorders and diseases of aging.

Pretzel plans to target mitochondrial diseases, a highly heterogenous group of conditions caused by DNA mutations in the mitochondria or the nucleus. These disorders are very rare, afflicting around one in 5,000 people.

Pretzel CEO Jay Parrish told BioSpace the funding “should enable us to get close to the clinic if not into the clinic with one or more programs.”

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Lung cancer is the third most common cancer in the U.S., according to the Centers for Disease Control and Prevention. Patients may be treated by a variety of approved immunotherapies and chemotherapies if surgery is not an option.

An oral pill for lung cancer named Lumakras, made by Amgen, shows promise for lung cancer patients who have tried many other treatments already with little improvement.

In phase 3 clinical trials, patients with non-small cell lung cancer received Lumakras or intravenous chemotherapy (docetaxel). The patients may have tried other treatments like immunotherapy.

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