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Category: bioengineering – Page 67

Artificial Cells — The Powerhouse of the Future

Assessing how energy-generating synthetic organelles could sustain artificial cells.

Researchers have assessed the progress and challenges in creating artificial mitochondria and chloroplasts for energy production in synthetic cells. These artificial organelles could potentially enable the development of new organisms or biomaterials. The researchers identified proteins as the most crucial components for molecular rotary machinery, proton transport, and ATP production, which serves as the cell’s primary energy currency.

Energy production in nature is the responsibility of chloroplasts and mitochondria and is crucial for fabricating sustainable, synthetic cells in the lab. Mitochondria are not only “the powerhouses of the cell,” as the middle school biology adage goes, but also one of the most complex intracellular components to replicate artificially.

How energy-generating synthetic organelles could sustain artificial cells — a powerhouse of the future

Energy production in nature is the responsibility of mitochondria and chloroplasts, and is crucial for fabricating sustainable, synthetic cells in the lab. Mitochondria are “the powerhouses of the cell,” but are also one of the most complex intracellular components to replicate artificially.

In Biophysics Reviews, by AIP Publishing, researchers from Sogang University in South Korea and the Harbin Institute of Technology in China identified the most promising advancements and greatest challenges of artificial mitochondria and chloroplasts.

“If scientists can create artificial mitochondria and chloroplasts, we could potentially develop synthetic cells that can generate energy and synthesize molecules autonomously. This would pave the way for the creation of entirely new organisms or biomaterials,” author Kwanwoo Shin said.

Immortality is attainable by 2030: Google scientist

Do you really want to live forever? Futurist Ray Kurzweil has predicted that humans will achieve immortality in just seven years. Genetic engineering company touts ‘Jurassic Park’-like plan to ‘de-extinct’ dodo bird Elon Musk ‘comfortable’ putting Neuralink chip into one of his kids.

Read more ❯.

How cell mechanics influences everything

“People study cells in the context of their biology and biochemistry, but cells are also simply physical objects you can touch and feel,” Guo says. “Just like when we construct a house, we use different materials to have different properties. A similar rule must apply to cells when forming tissues and organs. But really, not much is known about this process.”

His work in cell mechanics led him to MIT, where he recently received tenure and is the Class of ’54 Career Development Associate Professor in the Department of Mechanical Engineering.

At MIT, Guo and his students are developing tools to carefully poke and prod cells, and observe how their physical form influences the growth of a tissue, organism, or disease such as cancer. His research bridges multiple fields, including cell biology, physics, and mechanical engineering, and he is working to apply the insights from cell mechanics to engineer materials for biomedical applications, such as therapies to halt the growth and spread of diseased and cancerous cells.

How We’re Reverse Engineering the Human Brain in the Lab | Sergiu P. Pasca | TED

Neuroscientist Sergiu P. Pasca has made it his life’s work to understand how the human brain builds itself — and what makes it susceptible to disease. In a mind-blowing talk laden with breakthrough science, he shows how his team figured out how to grow “organoids” and what they call brain “assembloids” — self-organizing clumps of neural tissue derived from stem cells that have shown the ability to form circuits — and explains how these miniature parts of the nervous system are bringing us closer to demystifying the brain.

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The Rise Of Genetic Engineering | Gene-Editing | Documentary

Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.

The Rise Of Genetic Engineering (2022)
Writers: Kyle McCabe, Christopher Webb Young.
Stars: Rodolphe Barrangou, George Church, Mary Beth Dallas.
Genre: Documentary.
Country: United States.
Language: English.
Release Date: August 24, 2022 (United States)

Synopsis:
Genetic Engineering extends far beyond the controversial news headlines that obsess over ‘designer babies’. In the science community, gene-editing tools like CRISPR and PRIME editing will do nothing less than save the planet.

Methods like this allow scientists to alter and ‘re-program’ the genetics of living organisms.

This episode shows scientists at large using gene-editing technologies to revolutionize the food supply chain, bolstering food crops to prevent famines, and even speed up reforestation efforts that will reverse global warming. Genetic Engineering in farm animals is helping scientists to ‘select’ desirable traits, like physical features and gender. Incredibly, one scientist is using gene-editing technologies to resurrect the DNA of extinct species, like the Wooly Mammoth!

Despite some public concern, gene-editing is definitely a cause for hope in the fight against genetic disorders in humans. It’s already reversing a type of congenital blindness in children. And with the hyper-precision afforded by PRIME editing being prepared for clinical trials, a much more hopeful world will be revealed for families in the future.

Continue reading “The Rise Of Genetic Engineering | Gene-Editing | Documentary” | >

#176 Human organoids are new AI frontier; Listening to the big bang through the cosmic microwave background

Brainoids — tiny clumps of human brain cells — are being turned into living artificial intelligence machines, capable of carrying out tasks like solving complex equations. The team finds out how these brain organoids compare to normal computer-based AIs, and they explore the ethics of it all.

Sickle cell disease is now curable, thanks to a pioneering trial with CRISPR gene editing. The team shares the story of a woman whose life has been transformed by the treatment.

We can now hear the sound of the afterglow of the big bang, the radiation in the universe known as the cosmic microwave background. The team shares the eerie piece that has been transposed for human ears, named by researchers The Echo of Eternity.

Could AI-powered object recognition technology help solve wheat disease?

A new University of Illinois project is using advanced object recognition technology to keep toxin-contaminated wheat kernels out of the food supply and to help researchers make wheat more resistant to fusarium head blight, or scab disease, the crop’s top nemesis.

“Fusarium head blight causes a lot of economic losses in wheat, and the associated toxin, deoxynivalenol (DON), can cause issues for human and animal health. The disease has been a big deterrent for people growing wheat in the Eastern U.S. because they could grow a perfectly nice crop, and then take it to the elevator only to have it get docked or rejected. That’s been painful for people. So it’s a big priority to try to increase resistance and reduce DON risk as much as possible,” says Jessica Rutkoski, assistant professor in the Department of Crop Sciences, part of the College of Agricultural, Consumer and Environmental Sciences (ACES) at Illinois. Rutkoski is a co-author on the new paper in the Plant Phenome Journal.

Increasing resistance to any traditionally means growing a lot of genotypes of the crop, infecting them with the disease, and looking for symptoms. The process, known in plant breeding as phenotyping, is successful when it identifies resistant genotypes that don’t develop symptoms, or less severe symptoms. When that happens, researchers try to identify the genes related to and then put those genes in high-performing hybrids of the crop.