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Archive for the ‘bioengineering’ category

Aug 15, 2019

Swiss Scientists Upgrade CRISPR to Edit Many Genes at Once

Posted by in categories: bioengineering, biotech/medical, genetics

A research group at ETH Zurich, Switzerland, has made it possible to edit hundreds of genes at once with CRISPR gene editing.

CRISPR gene editing has revolutionized the biotech industry by providing an easy and quick way to genetically modify organisms. So far, however, CRISPR techniques have only managed to edit a maximum of seven genes at once. This limits the potential of the technique in creating cell therapies, since whole networks of genes need to be reprogrammed to control each cell’s fate.

The Swiss research group devised a way to overcome this limitation with a CRISPR technique able to edit 25 genes in one go. This number could also be increased to up to hundreds of genes at a time. This method therefore makes it possible to edit gene networks, and reprogram stem cells to become cell therapies such as skin cells or insulin-producing pancreatic cells.

Aug 15, 2019

Dr. Denise Montell — UC Santa Barbara — Department of Molecular, Cellular, and Developmental Biology — Anastasis — ideaXme — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, complex systems, cryonics, DNA, genetics, health, life extension, transhumanism

Aug 13, 2019

Platform for lab-grown heart cells lets researchers examine functional effects of drugs

Posted by in categories: bioengineering, biotech/medical, computing

Animal models provide benefits for biomedical research, but translating such findings to human physiology can be difficult. The human heart’s energy needs and functions are difficult to reproduce in other animals, such as mice and rats. One new system looks to circumvent these issues and provide a functional view of how different treatments can help ailing cells in the heart following oxygen and nutrient deprivations.

Researchers have unveiled a new silicon chip that holds human lab-grown for assessing the effectiveness of new drugs. The system includes heart cells, called cardiomyocytes, patterned on the chip with electrodes that can both stimulate and measure within the cells. The researchers discuss their work in this week’s APL Bioengineering.

These capabilities provide a way for determining how the restriction of blood supply, a dangerous state known as ischemia, changes a heart’s conduction velocity, beat frequency and important electrical intervals associated with heart function.

Aug 12, 2019

5 Reasons Jeff Bezos Should Bet Big On Synthetic Biology

Posted by in categories: bioengineering, biological, space

Jeff Bezos speaking at the grand opening of the Amazon Spheres, a new glass dome conservatory at the company’s Seattle headquarters. If going to space is vital for a thriving civilization, then we had better develop the synthetic biology tools and tech to enable it.

Aug 12, 2019

Multiplexed genome engineering

Posted by in categories: bioengineering, biotech/medical, genetics

The ability to modify multiple genetic elements simultaneously would help to elucidate and control the gene interactions and networks underlying complex cellular functions. However, current genome engineering technologies are limited in both the number and the type of perturbations that can be performed simultaneously. Here, we demonstrate that both Cas12a and a clustered regularly interspaced short palindromic repeat (CRISPR) array can be encoded in a single transcript by adding a stabilizer tertiary RNA structure. By leveraging this system, we illustrate constitutive, conditional, inducible, orthogonal and multiplexed genome engineering of endogenous targets using up to 25 individual CRISPR RNAs delivered on a single plasmid. Our method provides a powerful platform to investigate and orchestrate the sophisticated genetic programs underlying complex cell behaviors.

Aug 10, 2019

Don’t change your DNA at home, says America’s first CRISPR law

Posted by in categories: bioengineering, biotech/medical, genetics, law

A California “human biohacking” bill calls for warnings on do-it-yourself genetic-engineering kits.

Aug 9, 2019

China approves ethics advisory group after CRISPR-babies scandal

Posted by in categories: bioengineering, biotech/medical, ethics

Bioethicists hope a national committee will help close loopholes in the country’s biomedical ethics regulations.

Aug 9, 2019

Bill Faloon, Director / Co-Founder of Life Extension Foundation — ideaXme Show — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, business, genetics, health, life extension, neuroscience, posthumanism, transhumanism

Aug 8, 2019

CRISPR Gene Editing Is Being Tested In Human Patients And Scientists Admit They Do Not Know “What The Long-Term Effects Of Man-Made Edits To The Human Genome Might Have”

Posted by in categories: bioengineering, biotech/medical, entertainment

Scientists agree that CRISPR holds great promise in giving researchers unprecedented power to snip out abnormal stretches of DNA, But there are still significant questions about how safe and effective CRISPR gene editing will be once it’s unleashed in the human body. CRISPR works well enough in the lab, in a dish of human cells, but as with any technology, there are glitches. Some studies have shown that the gene editing goes awry once in a while, splicing incorrect places in the genome. Then there is the bigger question of what longer term, unanticipated effects man-made edits to the human genome might have… (READ MORE)

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Aug 8, 2019

Bill Faloon: A Life Long Quest To Reverse Human Aging!

Posted by in categories: bioengineering, biotech/medical, cryonics, education, food, life extension, quantum physics, transhumanism

Ira Pastor, ideaXme longevity and aging Ambassador and Founder of Bioquark interviews Bill Faloon, Director and Co-Founder, Life Extension Foundation and Founder of The Church Of Perpetual Life.

Ira Pastor Comments:

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