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Audible Books & Originals

THE AUDIOBOOK OF “WHY SPACE? THE PURPOSE OF PEOPLE” IS LIVE! CAN YOU HEAR ME! IT’S LIVE I SAY!

Sorry. Anyway, I know some of you are listeners rather than readers. While for me it is odd to consider listening to my own voice for several hours, I hope you do enjoy it!


Amazon.com: Why Space?: The Purpose of People (Audible Audio Edition): Rick Tumlinson, Rick Tumlinson, Manuscripts Press: Audible Books & Originals.

Pneumatic-suction robot clears 75,000 lb of cargo an hour

It’ll likely be a while before we have humanoid robots taking over our household chores, but what you can count on sooner is seeing more robots in industrial settings, like factories and warehouses.

Robots already move pallets and bins of goods across warehouse floors, replacing forklifts. There are also articulated arms involved in packaging tasks, and even assembly operations.

A startup founded by Massachusetts Institute of Technology (MIT) alumni wants these bots to do some heavy lifting, literally. Pickle Robot Company’s robot systems feature AI smarts, cameras, sensors, and enormous single-armed machines to unload shipping containers filled with cases weighing up to 50 lb (22.5 kg) each.

Abstract: For those interested in fertility regulation, endometriosis, adenomyosis, and endometrial cancer…

Francesco J. DeMayo & team discover uterine ZMIZ1 co-regulates estrogen receptor to establish and maintain pregnancy and general uterine health via cell growth responses and preventing uterine fibrosis:

The figure shows epithelial cell DNA synthesis (reflected by EdU incorporation) was inhibited by Zmiz1 deletion.


1Pregnancy & Female Reproduction Group, Reproductive and Development al Biology Lab, NIEHS, Research Triangle Park, North Carolina, USA.

2Inotiv-RTP, Durham, North Carolina, USA.

3Division of Hematology-Oncology, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA.

Plant used in folk medicine has anti-inflammatory anti-arthritic effects, study confirms

In Brazil, researchers from the Federal University of Grande Dourados (UFGD), the State University of Campinas (UNICAMP), and São Paulo State University (UNESP) have conducted a study that confirmed the safety and anti-inflammatory, analgesic, and anti-arthritic properties of the Joseph’s Coat plant (Alternanthera littoralis).

Native to the Brazilian coast, this plant has been used in folk medicine to combat inflammation, microbial infections, and parasitic diseases. Until now, there has been little pharmacological evidence to support these applications or analyze their safety.

The study is published in the Journal of Ethnopharmacology.

PreTA-mediated metabolism of 5-fluorouracil by intratumoral Citrobacter freundii drives chemoresistance in pancreatic cancer

Xu et al. report that intratumoral Citrobacter enrichment correlates with poor overall survival in pancreatic cancer patients. An intratumoral Citrobacter freundii strain metabolizes 5-fluorouracil (5-FU) into inactive products via PreTA. Gimeracil, an inhibitor of human dihydropyrimidine dehydrogenase, preserves 5-FU efficacy by blocking PreTA activity.

Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases

Despite the great technological and medical advances in fighting viral diseases, new therapies for most of them are still lacking, and existing antivirals suffer from major limitations regarding drug resistance and a limited spectrum of activity. In fact, most approved antivirals are directly acting antiviral (DAA) drugs, which interfere with viral proteins and confer great selectivity towards their viral targets but suffer from resistance and limited spectrum. Nowadays, host-targeted antivirals (HTAs) are on the rise, in the drug discovery and development pipelines, in academia and in the pharmaceutical industry. These drugs target host proteins involved in the virus life cycle and are considered promising alternatives to DAAs due to their broader spectrum and lower potential for resistance.

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