A genetic thread stretches across five centuries, connecting living descendants to the Renaissance master through his prolific father—and newly excavated remains could prove it.
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Scientists observe Einstein’s gravity in the quantum world for the first time
Physicists have directly observed a long-predicted quantum effect of gravity, putting one of Einstein’s foundational ideas to a striking new test. Using ultracold atoms, researchers split an atom’s quantum wave so that one part was held in place while the other fell freely under gravity, then reunited the two to measure the tiny difference that emerged.
Plasmalogens Eliminate AgingAssociated Synaptic Defects and MicrogliaMediated Neuroinflammation in Mice
Neurodegeneration is a pathological condition in which nervous system or neuron losses its structure, function, or both leading to progressive neural degeneration. Growing evidence strongly suggests that reduction of plasmalogens (Pls), one of the key brain lipids, might be associated with multiple neurodegenerative diseases, including Alzheimer’s disease (AD). Plasmalogens are abundant members of ether-phospholipids. Approximately 1 in 5 phospholipids are plasmalogens in human tissue where they are particularly enriched in brain, heart and immune cells. In this study, we employed a scheme of 2-months Pls intragastric administration to aged female C57BL/6J mice, starting at the age of 16 months old. Noticeably, the aged Pls-fed mice exhibited a better cognitive performance, thicker and glossier body hair in appearance than that of aged control mice. The transmission electron microscopic (TEM) data showed that 2-months Pls supplementations surprisingly alleviate age-associated hippocampal synaptic loss and also promote synaptogenesis and synaptic vesicles formation in aged murine brain. Further RNA-sequencing, immunoblotting and immunofluorescence analyses confirmed that plasmalogens remarkably enhanced both the synaptic plasticity and neurogenesis in aged murine hippocampus. In addition, we have demonstrated that Pls treatment inhibited the age-related microglia activation and attenuated the neuroinflammation in the murine brain. These findings suggest for the first time that Pls administration might be a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration.
Plasmalogens (Pls) are a special type of vinyl ether-bonded phospholipids actively participating in structure and function of biological membranes. Approximately 20% of phospholipids are plasmalogens in human tissue, where they are particularly rich in the brain, heart, and immune cells (Lessig and Fuchs 2009; Braverman and Moser 2012). In brain, ethanolamine plasmalogens (PlsEtns) constitute approximately 60 and 80% of the total ethanolamine phospholipids in gray and white matter, respectively (Macala et al., 1983). Pls are also concentrated in specialized membranes, such as sarcolemma, myelin, and synaptic vesicles (Post et al., 1988; Takamori et al., 2006; Poitelon et al., 2020). Reduced levels of PlsEtns have been found to be associated with aging (Pradas et al., 2019) and several neurodegenerative diseases, including Alzheimer’s disease (AD) (Guan et al., 1999; Han et al., 2001; Goodenowe et al., 2007; Wood 2010; Wood et al., 2015; Yamashita et al.
Folding Giant AI Brains Into Your Pocket
A team of researchers proved a simple mathematical law — the “linearity theorem” — that lets engineers predict, in advance and with precision, exactly how compressing an AI model will affect its intelligence. No more guess-and-check. No more crossing your fingers and hoping a 70-billion-parameter model doesn’t collapse into gibberish after compression.
A global research team just proved a simple mathematical law that lets engineers shrink massive AI models onto ordinary laptops and phones — without guessing, and without dumbing them down.
Stable Singularity of the Euler Equations on R^3 without forcing
In the theory of partial differential equations (PDEs), an important problem is analyzing whether there is loss of regularity in finite time, even when there is smooth initial data. This is known as singularity formation, or blowups. A famous one is whether fluid dynamics represented by Navier-Stokes equations experiences such blowups, and is one of the unsolved Millennium prize problems.
A closely related problem is known as the Euler problem and it represents inviscid flow, i.e., it lacks the viscosity term present in the Navier-Stokes equation. Intuitively the lack of viscosity makes it easier for blowups to happen, but it is still an open problem if such blowups occur in free space (R^3).
Super-resolution imaging reveals that cohesin prevents local mixing of compact, active genome domains
The human genome is about two meters (6.6 feet) long, yet it is folded inside a cell nucleus only about 10 micrometers in diameter. To fit into this tiny space, DNA is wrapped around histone proteins to form nucleosomes, which are further organized into chromatin. For decades, chromatin has often been described in two simple forms: euchromatin, which is active, open and accessible, and heterochromatin, which is more compact and repressed.
However, a new study from an international team led by Kazuhiro Maeshima, a professor at the National Institute of Genetics, ROIS (Research Organization of Information and Systems) and SOKENDAI, has challenged this simple textbook view. The researchers demonstrated that euchromatin in living human cells is not merely open and loose but forms dynamic condensed domains. This domain organization helps prevent the mixing of neighboring domains.
The team further found that cohesin, a ring-shaped protein complex best known for organizing genome architecture, prevents local mixing between these condensed euchromatic domains for proper gene regulation in living human cells. The study was published in Nature Genetics on Sept. 8, 2026.
