A transient, postoperative window of blood-brain barrier permeability enables repurposing of clinically used liposomal nanoparticles for glioblastoma.
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Renal replacement therapy in patients under extracorporeal membrane oxygenation: a narrative review
The use of extracorporeal membrane oxygenation (ECMO) has expanded for severe respiratory and circulatory failure. Acute kidney injury (AKI) is one of the most frequent complications. Up to 85% of ECMO patients develop AKI and approximately half of them require renal replacement therapy (RRT) making a comprehensive understanding of both therapies and their interaction essential for patient management. However, evidence to guide ECMO-specific RRT strategies remains limited.
ECMO-related AKI arises from a complex interplay between patient and circuit factors that promote inflammation, endothelial injury, and tubular damage. Timing of RRT initiation in ECMO patients often relies on criteria used in the general critically ill population. Fluid overload is consistently associated with worse outcomes, and observational data suggest that earlier RRT, primarily to control fluid balance, may improve survival although randomized trials in ECMO patients are lacking. All RRT modalities can theoretically be used, but continuous techniques are preferred. RRT can be delivered via a parallel circuit using a dedicated venous catheter or integrated into the ECMO circuit. Integrated configurations reduce the need for additional vascular access and may prolong filter lifespan but require careful pressure management and team expertise to avoid alarms, hemolysis, and air embolism.
Chemists unlock Appel fluorination with potassium fluoride
Alcohols are among the most abundant building blocks in chemistry. Fluorinated compounds, meanwhile, are essential for many modern medicines, crop protection products and advanced materials. Converting one into the other, however, has traditionally relied on toxic, thermally unstable reagents such as DAST (diethylaminosulfur trifluoride) that make large-scale manufacturing operationally demanding.
Researchers are therefore seeking safer and more practical ways to carry out these fluorination reactions. One major goal is to use simple, inexpensive and widely available fluoride sources such as potassium fluoride in order to make the process safer, more scalable and more sustainable.
Infants eye contact ‘tune in’ to speaker’s brainwaves and learn language
Infants use eye contact with speakers to work out what to pay attention to and synchronise their brainwaves, helping them learn language, scientists have shown.
Infants are surrounded by a vast range of stimuli that compete for their attention – sights, sounds, voices – and must somehow work out which things are worth paying attention to and learning from. To do this, they often rely on social cues – eye contact, ‘baby speak’ or someone calling their name, for example – but how this helps with learning is not clear.
The researchers have previously shown that when an infant and adult make eye contact, their brainwaves synchronise with each other.
Sugar has been discovered in space and it could change the search for alien life
Scientists have found natural sugars floating in interstellar space – and it could fundamentally change the search for alien life.
Researchers spotted erythrulose, found on Earth in raspberries and fake tan, towards the middle of our galaxy.
It could help answer one of the biggest questions about the origins of life on Earth, and how it could have formed elsewhere in the universe.
Beyond oncogenesis: the unexplored benefits of viruses in cancer immunity
The study of tumour virology has traditionally focused on oncogenic viruses and their associated mechanisms of cancer initiation and promotion. Yet certain viral exposures can be beneficial by enhancing antitumour immunity. In this Review, Wang et al. explore the increasingly emerging evidence of protective roles of viruses in cancer immunity and how this knowledge could be harnessed to develop a virome-guided framework for cancer immunoprevention.
World’s #1 Brain Surgeon: The Truth About Protecting Your Brain After 40
Ask most people what a brain chip does and they will tell you it reads your mind. Dr. Michael Lawton implants these devices, and he says that is not what comes off them. He is President and CEO of Barrow Neurological Institute in Phoenix, the hospital where Neuralink’s first human implant was performed, and he has completed more than 10,000 brain operations and clipped around 5,500 aneurysms. Louisa sat down with him inside Barrow to find out what the electrodes actually pick up, how far the technology has come, and where it stops.
He walks through the surgery itself. The device goes into the hand knob, one small lobule of the motor cortex, where 64 electrodes have already become 108. The threads carrying them are about a tenth the thickness of a hair, so a robot inserts them while avoiding every arteriole on the surface. You’ll hear what Nolan Arbaugh, Neuralink’s first patient, can now do with a cursor at world record speed, and why Lawton can’t keep up with him in a head to head.
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https://neuroathletics.substack.com/p… your risk of Alzheimer’s with my science-backed protocol for women 30+: https://go.neuroathletics.com.au/yout… Subscribe to The Neuro Experience for evidence-based conversations at the intersection of brain science, longevity, and performance. _____ TOPICS DISCUSSED 00:00 Intro: The Brain Surgeon at Neuralink’s First Hospital 00:39 The Guy Who Does the Cases Nobody Else Wants 02:17 A Day in the Life: 5:30am Starts and Three Surgeries 03:20 “Game Tape”: Reviewing Every Operation Like an Athlete 04:24 The Surgeon Athlete and Why Surgery Is a Physical Skill 05:32 Fifty Years From Now: What Happens to Neurosurgery 06:11 The ROSA Robot and Mapping a Seizure Focus 08:16 Deep Brain Stimulation and Hitting an Exact Target 08:52 Will We All Be Operated On by Robots? 10:02 The Brain AVM: The One Case a Robot Can’t Take 11:18 Why Bleeding Breaks a Robot: The Waymo Problem 13:15 What a Brain-Computer Interface Actually Does 14:49 The Hand Knob: 108 Electrodes in One Small Spot 15:50 Cursor Control at World Record Speed 16:31 Inside the Implant: Threads a Tenth the Width of a Hair 17:27 “No, the Chip Cannot Read Your Thoughts” 17:58 What the Device Really Reads: A Train of Spikes 19:18 From Movement to Sensation: What Comes Next 19:48 Why Restoring Sight Is So Much Harder 20:58 The 1943 Paper That Predicted All of This 22:37 Elon, Telepathy, and What’s Actually Possible 23:00 Boosting Creativity and Intelligence in 50 Years 25:10 “When I Retire, We’ll Be Treating Depression and Addiction” 26:04 Alzheimer’s: Light Therapy and the Blood-Brain Barrier 27:11 Treating the Disease vs Preventing It 28:25 10,000 Operations: How He Feels About Robots Taking Over 29:54 Neuroplasticity: How Nolan’s Brain Learned the Device 31:34 What Actually Changes at the Neuron Level 32:04 Patient Two and the Robotic Arm 32:42 5,500 Aneurysms: The Cases That Stay With Him 33:16 Cardiac Standstill: Cooling a Brain to 15 Degrees 35:46 What Separates a Great Surgeon From an Average One 36:17 Traits of Greatness: The Formula Nobody Has Cracked 37:21 The Phone Call in the Middle of a 16-Hour Surgery 39:35 “I Must Have Been Born for This” 41:26 Can You Tell How Old a Brain Is Just by Looking? 43:12 Why Alzheimer’s Is Invisible in a Living Brain 44:14 What a Neurosurgeon Does to Protect His Own Brain 44:40 “Alcohol Will Be Viewed Like Cigarettes in the 60s” 45:13 Peptides, Injectables, and Zero Supplements 46:52 The Last Generation to Operate With Open Hands 48:10 How Louisa Found Him on Twitter in 2021 48:53 The Six Mysteries of the Mind 49:14 Which One Gets Solved First, and Which May Never 50:03 Is Consciousness in the Tissue? 51:39 Memory: The Circuitry We Still Can’t Explain 53:18 Why Consciousness Is Harder Than Memory 55:12 Louisa’s Father’s Stroke 56:02 Advice for Anyone Watching a Parent Decline 56:21 His Sister’s Brain Tumor and How He Carries It 57:38 A World Where Stroke Is an Outpatient Repair 58:40 Forty Years On, Finally at the Dawn _______ Thank you to our sponsors Timeline (Mitopure): https://timeline.com/neuro Mitopure now starts at $79 Ogee: https://ogee.com Use code NEURO for a discount on the Crystal Contour Collection Kion (Kion Aminos): https://getkion.com/neuro for a 20% discount Function Health: https://functionhealth.com/LouisaNicola Use code NEURO25 for a $25 credit _______ I’m Louisa Nicola — clinical neurophysiologist — Alzheimer’s prevention specialist Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: / louisanicola_ Twitter :
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TOPICS DISCUSSED
00:00 Intro: The Brain Surgeon at Neuralink’s First Hospital.
00:39 The Guy Who Does the Cases Nobody Else Wants.
02:17 A Day in the Life: 5:30am Starts and Three Surgeries.
03:20 \