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Human brain stimulation engages different gene programs in different cell types

Nature’s brief summary of a paper (by Moore et al.) which transcriptomically maps how electrical stimulation of ex vivo human brain tissue triggers a range of previously unknown gene expression programs.


Genetic signatures of stimulation coincide with the strengthening of cell assemblies in samples of human brain tissue.

Can AI Help Detect Disease Before Your Pet Gets Sick? | Dr. Ragen McGowan — Nestlé Purina

Can AI tell how your pet feels? Dr. Ragen McGowan, Ph.D. — Director of Global Digital & AI Product Development, Nestlé Purina North America.


What if your dog or cat could tell you how they’re feeling?

Today, artificial intelligence may be giving us a new way to listen.

By continuously monitoring things like activity, eating, sleep, elimination and other behaviors, AI can begin to establish what’s normal for an individual animal — and potentially detect subtle changes that humans would never notice.

Dr. Ragen McGowan, Ph.D. is Director of Global Digital & AI Product Development at Nestlé Purina (https://www.purina.com/pet-experts/rm

The Agentic AI and Quantum Convergence: Innovation and Cybersecurity Imperatives for US Government Agencies and Contractors$

GovCon Expert Chuck Brooks outlines the governance, cryptographic inventory and resilience steps agencies and contractors need now.

Skull channels as gateways for immune surveillance of the brain

The central nervous system (CNS), once considered immune privileged, is, in fact, protected by a dynamic immune compartment located in the meninges. These immune cells are crucial for brain protection, controlling neuroinflammation, and also supporting neural function. Recent studies show that meningeal immune cells, including myeloid and B cells, partly originate from the skull bone marrow, which communicates directly with the meninges via specialized skull channels identified in mice and humans. These channels allow immune cell trafficking and cerebrospinal fluid (CSF) exchange, positioning the skull marrow as a CSF-sensing niche. Therefore, understanding skull–meninges–brain interactions reveals a functional connection between bone marrow and the CNS, offering new insights into neuroimmune regulation and potential therapeutic strategies in neuroinflammatory conditions.

Galactic Gems Glisten in New Gallery From NASA’s Chandra

This gallery displays a collection of 16 galactic images from Chandra and other telescopes. Astronomers put galaxies into three main categories: spirals like our own Milky Way, ellipticals that are older and likely the results of mergers, and irregulars that can encompass a wide range of galactic phenomena. All types are represented in this collection. Each galactic image contains X-ray data from Chandra combined with data from telescopes such as NASA’s Webb, Hubble, IXPE, Swift, and NuSTAR, and others both in space and on the ground.

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