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Hemoglobin’s antioxidant role in brain cells points to new therapeutic avenue

Hemoglobin, long celebrated for ferrying oxygen in red blood cells, has now been revealed to play an overlooked—and potentially game-changing—antioxidant role in the brain.

In such as (ALS), Parkinson’s, Alzheimer’s, and aging, brain cells endure relentless damage from the aberrant (or excessive) (ROS). For decades, scientists have tried to neutralize ROS with antioxidant drugs, but most failed: they couldn’t penetrate the brain effectively, were unstable, or indiscriminately damaged healthy cells.

This new study, led by Director C. Justin Lee of the Center for Cognition and Sociality within the Institute for Basic Science (IBS) in Daejeon, South Korea, set out to identify the brain’s own defenses against a particularly harmful form of ROS—hydrogen peroxide (H2O2). The study has been published in Signal Transduction and Targeted Therapy.

A new perspective on how cosmological correlations change based on kinematic parameters

To study the origin and evolution of the universe, physicists rely on theories that describe the statistical relationships between different events or fields in spacetime, broadly referred to as cosmological correlations. Kinematic parameters are essentially the data that specify a cosmological correlation—the positions of particles, or the wavenumbers of cosmological fluctuations.

Changes in cosmological correlations influenced by variations in parameters can be described using so-called differential equations. These are a type of mathematical equation that connect a function (i.e., a relationship between an input and an output) to its rate of change. In physics, these equations are used extensively as they are well-suited for capturing the universe’s highly dynamic nature.

Researchers at Princeton’s Institute for Advanced Study, the Leung Center for Cosmology and Particle Astrophysics in Taipei, Caltech’s Walter Burke Institute for Theoretical Physics, the University of Chicago, and the Scuola Normale Superiore in Pisa recently introduced a new perspective to approach equations describing how cosmological correlations are affected by smooth changes in kinematic parameters.

SARS-CoV-2 infects testicular cells and uses cellular machinery to replicate, study finds

The COVID-19 virus hijacks the machinery of testicular cells that produce the hormone testosterone in order to replicate. It also appropriates the metabolic pathways of these cells and cholesterol, a precursor of testosterone, thereby altering lipid metabolism for its formation.

This has been verified in a study conducted in Brazil by researchers from the Araraquara School of Dentistry at São Paulo State University (FOAr-UNESP), in partnership with the Ribeirão Preto School of Medicine at the University of São Paulo (FMRP-USP), in the testicles of . The research is published in the journal Frontiers in Cellular and Infection Microbiology.

The study revealed the presence of SARS-CoV-2 particles in lipid inclusions and organelles responsible for testosterone production in Leydig cells for the first time. In addition, the researchers described the mechanism by which the virus interferes with the functioning of these testicular cells. The discovery helps explain why with severe COVID-19 have lower levels of testosterone, and possibly .

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