Imagine a house where footsteps supposedly echo through the hallways at night and doors close in empty rooms.
If you had to spend a night there, would explanations involving old floorboards and drafts be enough to settle your doubts?
As it happens, trusting a scientific explanation doesn’t necessarily close the door on ghosts.
Physical Superintelligence claims its research system proved an 18-year-old quantum computing conjecture in three days.
As a liquid that is easily stored and transported, ammonia (NH3) is an attractive carrier for hydrogen, which is used in fuel cells, semiconductor manufacturing, chemical processing, and other applications. However, breaking ammonia into hydrogen and nitrogen typically requires high temperatures, and the resulting gas mixture must undergo additional purification before the hydrogen can be used in many applications.
MIT researchers have now developed an electrochemical approach to promote hydrogen release from ammonia while simultaneously separating and concentrating the hydrogen into a high-purity stream. Their strategy, which uses electricity to speed up the extraction, reduces the temperature and energy required to recover hydrogen from ammonia and other hydrogen carriers.
In a new study, the researchers showed that their approach can generate highly concentrated, pure streams of hydrogen.
Could inhibiting factor XIa prevent secondary stroke without increasing bleeding risk?
Construction scheduling in active airport environments is complicated by restricted work windows, operational access requirements, and dependencies that may not be fully reflected in conventional critical-path analysis. This study examines an LLM-augmented framework for identifying schedule vulnerabilities by combining Critical Path Method (CPM) indicators, a heuristic Baseline Risk Index (BRI), large language model (LLM) interpretation, and probabilistic duration analysis. The framework was examined through an anonymized airside rehabilitation project at a major U.S. airport, using 1,591 baseline schedule records and nine retrospective validation cases. Baseline schedule characteristics were analyzed separately from subsequent project outcomes to reduce hindsight bias. Monte Carlo simulation was applied at the activity level using provisional duration distributions and risk-event assumptions. The results revealed substantial differences in schedule flexibility across work packages. Work Package E had approximately 67% of its eligible activities within one to five days of total float and subsequently experienced a 32-day schedule variance. Work Package D recorded a 70-day variance, despite having lower low-float exposure. Meanwhile, the project’s substantial-completion milestone was achieved on its baseline target date. The LLM helped consolidate schedule-risk indicators into structured observations for planner review, although no independent improvement over conventional CPM and BRI analysis was demonstrated. The probabilistic results provided comparative activity-duration exposure rather than project completion forecasts. These findings suggest that combining conventional schedule measures with contextual risk screening and structured interpretation can support earlier recognition of localized vulnerabilities, while further validation is needed to establish measurable improvements in planning performance.
Large Language Models, Construction Scheduling, Airfield Construction, Schedule Risk, Critical Path Method, Monte Carlo Simulation, Probabilistic Scheduling, Risk-Informed Planning, Artificial Intelligence
Iron accumulation is a conserved hallmark of cellular as well as organismal aging, yet its mechanistic role in senescence remains largely elusive. Here we show that the accumulation of ferrous iron (Fe2+) in lysosomes, a unique feature of senescent cells, is crucial for the induction of multiple senescence-associated phenotypes. Intriguingly, we found that this lysosomal Fe2+ sequestration is rendered “safe” by a dual metabolic adaptation that confers robust resistance to ferroptosis. First, Fe2+ accumulation triggers lysosomal alkalinization and subsequent cholesterol accumulation, which reinforces the lysosomal membrane against permeabilization. Second, senescent cells partition polyunsaturated fatty acids into lipid droplets, thereby depleting these ferroptosis-prone substrates from cellular membranes. Our findings establish that such cholesterol-enabled safe sequestration of Fe2+ serves as a central modulator linking senescence-associated remodeling to ferroptosis resistance. Modulating this lysosomal iron-centered pathway may provide new opportunities to target and control the behavior of senescent cells.
The lead author told Newsweek delays could be especially consequential for younger Alzheimer’s patients.
We demonstrate submicrometer focusing of isolated attosecond pulses in the extreme ultraviolet region using a custom ellipsoidal mirror. The obtained focal spot sizes were verified using knife-edge measurements with a sharp silicon edge, confirming reproducible dimensions down to 0.46 μm × 0.36 μm (full width at half maximum), demonstrating near-diffraction-limited focusing performance. Focusing a 1.1-GW tabletop isolated attosecond pulse source yields a peak intensity of 3 × 1015 W/cm2, and a realistic pathway toward 1016 W/cm2 is obtained by optimizing the beamline throughput. These results establish a practical route toward attosecond nonlinear optics in both gas and solid phases, driven by intense extreme ultraviolet fields.
Researchers revealed an ultralow-barrier collective sliding mechanism mediated by domain walls, as well as defect-induced pinning of the sliding motion. They found that twisted bilayer MoS₂ moiré superlattices can undergo spontaneous long-range interlayer sliding at room temperature, while a sulfur-vacancy concentration of only about 0.1% can turn the motion into localized oscillations.
The study was conducted by a collaborative team involving professors Zhang Jin and Shi Xinghua from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) and professor MENG Sheng from the Institute of Physics (IOP) of CAS.
The findings were published in the Journal of the American Chemical Society.
In the past 5 years, substantial changes have been made in the use of intravenous thrombolysis (IVT) in patients with acute ischemic stroke. Integrating IVT with endovascular thrombectomy, which improves outcomes in patients with stroke due to large cerebral vessel occlusion, has been a particular challenge. This review discusses the underlying vascular targets for IVT and thrombectomy, the increasing use of tenecteplase instead of alteplase, broadening indications for the use of IVT, and ancillary drugs and dosing methods that may augment the success of IVT.
