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Why High Tech Cars Might Age Like Smartphones
This is why we drive a 14-year-old car and we’ll keep driving it as long as we can: [ https://youtu.be/_FfIx2cOEYs?si=8Wq0biyGETqw-nZp](https://youtu.be/_FfIx2cOEYs?si=8Wq0biyGETqw-nZp)
Software defined vehicles offer advantages their analog rivals can‘t compete with. But the hardware and software in them needs to be maintained, and some owners have found their cars suddenly obsolete or without key features. CNBC talked with industry figures, including Rivian Chief Software Officer Wassym Bensaid about the promise of software defined vehicles and how his company is trying to handle the challenges this new form of ownership poses.
Chapters:
00:00 Introduction.
01:22 Chapter 1: Software-defined cars.
02:34 Chapter 2: The problem.
04:39 Chapter 3: Keep it running.
Produced by: Robert Ferris.
Shot and edited by: Darren Geeter.
Additional Camera: Andrew Evers.
Senior Managing Producer: Tala Hadavi.
Additional footage: Getty Images.
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Humans Could Live for Centuries | Aubrey de Grey
Aubrey de Grey believes ageing is accumulated damage in a biological machine and argues that medicine may eventually become capable of repairing that damage faster than it appears. He gives humanity a 50/50 chance of reaching what he calls “longevity escape velocity” within the next 12–15 years.
Peter and Aubrey discuss why the body ages, the seven categories of damage that must be repaired, stem-cell and gene therapies, the mouse experiment that could transform the field and why Aubrey believes rejuvenation treatment will ultimately be available to everyone rather than reserved for the wealthy.
They also explore what happens to population, work, fertility, relationships, religion and the meaning of life if people stop getting sick from ageing. Aubrey explains why AI cannot replace the missing biological experiments, why longevity research remains so difficult to fund, and why he is driven by the 110,000 people he says die from ageing-related causes every day.
TIMESTAMPS:
00:00:00 — Trailer.
00:00:48 — Can We Cure Ageing?
00:04:24 — The 12–15 Year Prediction.
00:06:17 — The Body Is a Machine.
00:15:21 — How Aubrey Entered Longevity.
00:18:45 — Would You Want to Live Forever?
00:20:15 — Does Longevity Change Risk?
00:21:53 — Will Population Explode?
00:24:22 — Can You Choose Your Age?
00:30:19 — The Seven Types of Ageing Damage.
00:36:54 — What Rejuvenation Treatment Looks Like.
00:45:35 — Will It Be Expensive?
00:48:39 — Who Would Refuse It?
00:53:00 — Why Longevity Research Lacks Funding.
00:56:02 — The Mouse Experiment.
01:00:18 — The Breakthrough That Changes Everything.
01:01:35 — Does Death Give Life Meaning?
01:05:22 — Bryan Johnson and AI
01:12:32 — AlphaFold, AGI and AI Risk.
01:15:13 — Why Funding Is So Hard.
CONTACT PETE:
› Website – https://www.petermccormack.com/
› Feedback – https://www.petermccormack.com/contact.
› Email – [email protected].
› Instagram – / mccormack555
› X/Twitter – https://twitter.com/petermccormack/
CONNECT WITH AUBREY DE GREY:
Why Does CLAUDE.md Keep Growing? Catastrophic Remembering in Agentic Coding
Because adding a quick instruction to an AI’s guide file is fast and low-risk, developers continually tack on new rules whenever the AI makes a mistake (e.g., “Don’t use library X,” or “Always run tests with flag Y”). Over time, however, the original context and reasoning behind older instructions fade from human memory.
Agent instruction files like CLAUDE.md exhibit unbounded growth due to “catastrophic remembering,” a process where the original rationale for instructions is lost, making safe deletion difficult…
The New Stakes for Business Viability in the Digital Era: AI, Quantum, and the Expanding Cyber Threat Landscape
A company’s ability to survive throughout a large portion of the industrial era rested on well-known fundamentals: capital, clients, staff, intellectual property, physical infrastructure, dependable suppliers, and efficient management. These principles are still important. However, digital trust and resilience have become an additional factor in organizational survival due to the global economy’s digital transition.
Interconnected networks, cloud computing, software, data, digital identities, third-party providers, Internet of Things (IoT) devices, artificial intelligence, and increasingly intricate technology ecosystems are now essential to nearly every enterprise. Therefore, the security of a modern organization depends on the digital relationships and technology it uses.
A New Era of Precision Neuromodulation in Psychiatry
Over the past century, advances in neuroimaging and cognitive neuroscience reshaped how we understand psychiatric disorders, expanding the portfolio of evidence-based treatments while routine clinical practice has mostly relied on trial and error. Precision medicine has steadily extended to psychiatry, and today we can target specific cortical or subcortical brain regions within defined pathological circuits to individualize treatments to particular symptoms. Neuromodulation sits at the frontier of this shift in psychiatry, with extensive ongoing research to identify optimal treatment targets and protocols personalized to individuals’ neural circuitry.
Neuromodulation using neuronavigation achieves precise clinical target identification through computer-assisted integration of multimodal brain imaging. Neuron avigated approaches have been central to deep brain stimulation (DBS) for decades. More recent advances in functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) extended this framework from isolated gray matter nuclei toward pathological neural circuits through resting-state functional connectivity analysis and tractography, which enabled the identification of connectomic fingerprints associated with specific symptom clusters, or circuitopathies, a concept particularly relevant to psychiatric disorders, such as obsessive-compulsive disorder and depression.
New findings overturn 100-year-old assumption about common bacteria in the lungs
The human body is teeming with more than 35 trillion bacteria, coexisting in microbiomes inside the gut, mouth, lungs, skin and urogenital tract. While it’s now clear these microbes are associated with health and disease, scientists have only begun to uncover the full scale of their biology and functions.
In a striking example of just how much is still unknown, a new University of Michigan study overturns a 100-year-old assumption about one common bacterial resident of the lungs, Prevotella melaninogenica. The research is published in the Journal of Bacteriology.
The lab led by Ariangela Kozik, Ph.D., assistant professor of internal medicine at U-M Medical School and assistant professor of molecular, cellular and developmental biology at U-M, is interested in Prevotella because the bacteria are commonly found in the respiratory tract and reportedly associated with all manner of chronic conditions, yet are also found in healthy people. The genus is also widely thought to be an obligate anaerobe, incapable of surviving in the presence of oxygen.
Deep brain stimulation strengthens reward signals after one 20-minute session, study finds
A study from Emory University School of Medicine suggests that a single 20-minute session of noninvasive deep brain stimulation, paired with mindful breathing, may strengthen the brain’s response to reward and reduce anxiety. Changes in reward-related brain activity remained detectable for approximately one week after the session.