Transform geospatial relations into graphs for Graph Neural Networks and spatial network analysis — c2g-dev/city2graph
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Lab-created ‘SpudCell’ marks ‘stunning’ step toward building life from scratch
Researchers have long dreamed of creating cells in the lab, to both understand life’s fundamentals and produce cells that can be better engineered to make certain compounds. But most have set their sights lower and tried to replicate individual cell functions, such as feeding or growth. Putting multiple functions together has been extremely challenging, because each tends to work best under a different set of conditions, for instance a certain amount of magnesium or a specific level of acidity. “Being able to incorporate all of these modules together in a synthetic cell is the feat that the field has been waiting for,” says Job Boekhoven, a systems chemist at the Technical University of Munich, although he stresses that the new paper’s claims need to be peer reviewed.
Evaluating BindCraft for Generative Design of HighAffinity Peptides Biology
Interesting paper evaluating BindCraft (a generative AI tool for making small proteins) for peptide generation. BindCraft was found to work well for generating peptides to bind certain protein targets, while it failed completely for other protein targets. The protein targets for which experimental peptide hits were discovered were the ones with more structural data available, likely reflecting BindCraft’s training data.
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Study suggests 40Hz sensory stimulation may benefit some Alzheimer’s patients for years
A new research paper documents the outcomes of five volunteers who continued to receive 40Hz light and sound stimulation for around two years after participating in an MIT early-stage clinical study of the potential Alzheimer’s disease (AD) therapy. The results show that for the three participants with late-onset Alzheimer’s disease, several measures of cognition remained significantly higher than comparable Alzheimer’s patients in national databases. Moreover, in the two late-onset volunteers who donated plasma samples, levels of Alzheimer’s biomarker tau proteins were significantly decreased.
The three volunteers who experienced these benefits were all female. The two other participants, each of whom were males with early-onset forms of the disease, did not exhibit significant benefits after two years. The dataset, while small, represents the longest-term test so far of the safe, noninvasive treatment method (called GENUS, for gamma entrainment using sensory stimuli), which is also being evaluated in a nationwide clinical trial run by MIT-spinoff company Cognito Therapeutics.
“This pilot study assessed the long-term effects of daily 40Hz multimodal GENUS in patients with mild AD,” the authors wrote in an open-access paper in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association. “We found that daily 40Hz audiovisual stimulation over 2 years is safe, feasible, and may slow cognitive decline and biomarker progression, especially in late-onset AD patients.”
World’s first raw earth material 3Dprinted house is ready for residents
Italian 3D-printing company WASP and partner Mario Cucinella Architects have completed building the first TECLA 3D-printed house
Mitochondrial Transplantation Rejuvenates Immune Cells
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