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A decade of CAR-T cell therapy at Mayo Clinic: From experimental treatment to new frontiers (VIDEO)

From early clinical trials to an established CAR-T Cell Therapy Program, Mayo Clinic has delivered the transformative therapy to over 1,500 patients.

A decade ago, chimeric antigen receptor-T cell therapy, or CAR-T cell therapy, was an experimental treatment only available through clinical trials. Today, Mayo Clinic offers CAR-T cell therapy at all three sites in Arizona, Florida and Minnesota and continues to explore new frontiers for the life-changing treatment.

That progress traces back to Mayo Clinic’s early involvement in research exploring CAR-T cell therapy for patients with few remaining options.

Printed electronics turn mattress protectors into fall-risk monitors

Australian medtech company Sleeptite and RMIT University researchers have secured a U.S. patent for smart bedding technology designed to monitor residents’ well-being in health care settings and identify fall risk so caregivers can intervene.

A recent study by RMIT and Sleeptite shows the technology can be manufactured using scalable production techniques while maintaining performance and durability.

Now, Sleeptite has unveiled the technology at The MedTech Conference—a high-profile gathering of medical technology industry leaders held in Boston—as part of an Australian trade delegation led by AUScelerate. The study is published in the journal Flexible and Printed Electronics.

New virtual assistant streamlines one of the most advanced microscopes

Some of the most important discoveries in materials science and structural biology come down to a simple question: Where, exactly, are the atoms? The arrangement of atoms determines nearly everything about how a material behaves in the real world—how strong it is, how it conducts electricity, how a battery stores energy, or how a drug binds to a cell.

To answer that question, scientists use transmission electron microscopes. Researchers at the Molecular Foundry, a U.S. Department of Energy (DOE) Office of Science user facility at Lawrence Berkeley National Laboratory (Berkeley Lab), operate several of these microscopes, including some of the most advanced in the world, capable of imaging structures roughly half the size of a hydrogen atom (or 60 billion times smaller than you). This gives outside researchers access to equipment they wouldn’t otherwise have access to.

That access to complex equipment comes with a steep learning curve. As a user facility, the Molecular Foundry hosts scientists from universities, companies, and other institutions who don’t have access to the specialized electron microscopes at their home labs. Some visiting researchers arrive with a semester of coursework in electron microscopy basics, but still need weeks of hands-on training to run the lab’s more advanced techniques.

Cracks that carry current: Virginia Tech researchers unlock the secrets of liquid metal and electricity

In a new study, mechanical engineering researchers reveal how microscopic cracks can turn an insulating material into an electrical conductor, perfect for electronics that need to stretch, bend, and flex.

Deleted AI chats may leave clues behind

Deleting a conversation with an artificial intelligence (AI) assistant may not erase everything the assistant remembers. Georgia Tech researchers have developed a tool that can recover deleted conversations from AI assistants running on Android phones. The tool, called ORISA, can also rebuild the recovered information into a working AI session.

The findings show that deleting an AI conversation on a phone does not necessarily mean it removes every trace.

The research could give digital investigators a new way to recover information from phones. It also raises privacy concerns for people who use AI assistants that run locally on their devices.

Deepseek-ai/dsh-superagent-prototype: Towards a More Autonomous Agent System

DeepSeek launches “Super-Agent,” a new open-source AI coding agent designed to rival Anthropic’s Claude Code.

DeepSeek’s Super-Agent is an open-source, always-on AI coding agent architecture released by DeepSeek’s Harness team on GitHub under the MIT license.

Positioned as an autonomous alternative to tools like Anthropic’s Claude Code, Super-Agent shifts the focus from model capability to solving human attention limits in software development.

Key Architecture: Two-Layer “Router & Worker”

Traditional terminal or single-session AI coding tools require constant human monitoring and prompt management. DeepSeek’s Super-Agent breaks this paradigm using a two-tier system:

1. The Router (The Triage Layer): An always-on, lightweight agent that monitors group chats (Slack, WeChat), GitHub pull requests, and CI/CD pipelines. It handles initial entry points, prioritizes triggers, and delegates work without executing shell commands itself.

2. Workers (Isolated Execution Sessions): Spun off by the Router, individual Workers use full-capability LLMs and shell toolsets to execute specific coding tasks in parallel.

Continue reading “Deepseek-ai/dsh-superagent-prototype: Towards a More Autonomous Agent System” | >

Large language models show product name convergence in drug recommendations

In a benchmark analysis spanning 123 disease–drug pairs and 1,440 sociodemographic profiles, five large language models recommended the same drug product for a given active ingredient in 97.5% of cases and favoured originator products over available generics.

Why TON 618 Is So Terrifying

Sources and scientific references:
Near-infrared spectroscopy of TON 618 and the widely cited estimate of approximately 66 billion solar masses, based on its Hβ emission-line width and optical luminosity: Shemmer et al. (2004), Near-Infrared Spectroscopy of High-Redshift Active Galactic Nuclei. I. A Metallicity–Accretion Rate Relationship. The Astrophysical Journal.
https://doi.org/10.1086/423607
A later quasar analysis listing an Hβ-based mass estimate of approximately 41 billion solar masses for TON 618, illustrating the dependence of the inferred mass on the adopted calibration: Ge et al. (2019), The Blueshift of C IV Broad Emission Line in QSOs. The Astronomical Journal.
https://doi.org/10.3847/1538-3881/ab0956
How astronomers estimate distant black hole masses from emission-line widths and luminosity, including the calibration and uncertainties of these methods: Vestergaard & Peterson (2006), Determining Central Black Hole Masses in Distant Active Galaxies and Quasars. II. Improved Optical and UV Scaling Relationships. The Astrophysical Journal.
https://doi.org/10.1086/500572
The formation and growth of massive black hole seeds in the early Universe, including accretion, radiation feedback, direct-collapse scenarios, and mergers: Inayoshi, Visbal & Haiman (2020), The Assembly of the First Massive Black Holes. Annual Review of Astronomy and Astrophysics.
https://doi.org/10.1146/annurev-astro… theoretical limit on growth through luminous gas accretion, approximately 50 billion solar masses for typical assumptions and up to 270 billion in extreme cases, with further growth through mergers and possible detection through gravitational lensing: King (2016), How Big Can a Black Hole Grow? Monthly Notices of the Royal Astronomical Society: Letters. https://doi.org/10.1093/mnrasl/slv186 An estimate of the Milky Way’s total stellar mass of approximately 61 billion solar masses, providing the basis for comparing TON 618’s estimated mass with the combined mass of our galaxy’s stars: Licquia & Newman (2015), Improved Estimates of the Milky Way’s Stellar Mass and Star Formation Rate from Hierarchical Bayesian Meta-Analysis. The Astrophysical Journal. https://doi.org/10.1088/0004-637X/806…
A theoretical limit on growth through luminous gas accretion, approximately 50 billion solar masses for typical assumptions and up to 270 billion in extreme cases, with further growth through mergers and possible detection through gravitational lensing: King (2016), How Big Can a Black Hole Grow? Monthly Notices of the Royal Astronomical Society: Letters.
https://doi.org/10.1093/mnrasl/slv186
An estimate of the Milky Way’s total stellar mass of approximately 61 billion solar masses, providing the basis for comparing TON 618’s estimated mass with the combined mass of our galaxy’s stars: Licquia & Newman (2015), Improved Estimates of the Milky Way’s Stellar Mass and Star Formation Rate from Hierarchical Bayesian Meta-Analysis. The Astrophysical Journal.
https://doi.org/10.1088/0004-637X/806…

Efficacy and safety of garetosmab, an activin A-blocking antibody, in fibrodysplasia ossificans progressiva (OPTIMA): a randomised, double-blind, placebo-controlled, phase 3 trial

Garetosmab substantially reduced the number of new heterotopic bone lesions, providing robust evidence of its potential to be an efficacious and generally well tolerated disease-modifying therapy for FOP.