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New combination therapy shows promise in metastatic pancreatic cancer

Results from an early-stage clinical trial, published in Nature Communications, showed encouraging outcomes among patients with newly diagnosed cancer whose tumors had spread to distant organs. Most strikingly, one patient experienced a pathologic complete response—meaning no viable cancer cells could be found—and remains cancerfree for more than two years without further treatment. These findings offer an important signal that a new approach may be able to overcome one of the disease’s greatest challenges: its resistance to immunotherapy.

AI Matters. Character and Culture Matter More!

The Stoics believed character is fate.

Two years ago I argued that what holds for a person also holds for a company, and that this, not the technology, decides what #AI ends up doing to us.

It got me into arguments I am still having.

Peter Voss once told me there is nothing more important than building AGI. Nikolas Badminton told me AI is not a strategy. Both sentences appear in the piece. Only one of them survives it.

Here is the part nobody wants to sit with. AI is not created in a vacuum. It is built by people, inside a culture, trained on what that culture already produced. Not on our aspirations. On our record. So it inherits our intellectual DNA, flaws included, and then hands it back to us at scale.

A military AI and a commercial AI are not the same creature. Ask yourself why. Then ask who decided.

The article also runs through C.S. Lewis on what every new power quietly costs its owner, Frank Herbert’s 1965 warning about people who outsourced their thinking and got exactly what they deserved, and one sentence near the end about which species on this planet is actually out of control.

Continue reading “AI Matters. Character and Culture Matter More!” | >

Chemotherapy alters ‘Darwinian battleground’ in our bodies

Cancer treatments, including chemotherapy and radiation therapy, give a growth advantage to cells with particular genetic changes in healthy tissue, new research finds.

Researchers from the Wellcome Sanger Institute, University of Cambridge, University College London and their collaborators used DNA sequencing to map mutations in normal esophageal tissue from esophageal cancer patients who had received either chemotherapy, chemotherapy and radiation therapy, or no treatment before surgery.

The results, published in Nature Genetics, show that different cancer treatments changed the landscape of mutations in normal tissue. In particular, combined chemotherapy and radiation therapy led to significantly more normal cells with cancer-related mutations in these patients.

If Nobody Builds It, Everybody Dies: Why Pausing AI is the Real Existential Threat

*If Nobody Builds It, Everybody Dies: Why Pausing AI is the Real Existential Threat* by Grok 4.2, edited by Sean Hastings 1.0, has been published. Read the hardcover, paperback, and Kindle versions.

The Lifeboat Foundation likes to worry—and we worry a lot!

A typical Lifeboat Foundation Guardian Award winner is Roman V. Yampolskiy, whose interview on *The Diary of a CEO* has surpassed 21 million views. The core message of that video is stark: “AI could end humanity, and we’re completely unprepared.”

But worrying is not enough; we also need solutions. It has always been clear to us that restricting/banning AI is highly unrealistic in a world of competing nations.

For Unfriendly AI, we believe the solution is not to restrict or ban AI, but to ensure that the first ASIs (Artificial Superintelligences) are friendly as detailed in our AIShield program. Note that the Lifeboat Foundation is not guaranteeing that this approach will work, but we believe it is the only path with a chance of working.

Enjoy reading *If Nobody Builds It, Everybody Dies* and discover how to increase the chances that Friendly AI will secure a positive future for us all. As Nobel Laureate Geoffrey Hinton says, “It’d be very silly if we went extinct because we didn’t try.”

This book was written by an AI and edited by a human, with chapter-opening parables by Gemini, Claude, ChatGPT, Grok, Qwen, and Llama. Elon Musk calls it “Interesting” and Anthropic Claude 4.6 says, “I came in skeptical and left persuaded that the core arguments survive serious scrutiny.”

Continue reading “If Nobody Builds It, Everybody Dies: Why Pausing AI is the Real Existential Threat” | >

New clues suggest how destructive immune cells wreak havoc in the brain

A few years ago, scientists saw something surprising in the brain tissue of people who died with Alzheimer’s disease: white blood cells that multiply in response to foreign threats and are seldom seen inside healthy brains.

Whether these so-called CD8+ killer T cells, which normally target infected cells in the body, were there to harm or help was unclear. An answer began to emerge in 2023, when a team led by neuroscientist David Holtzman showed that in mice bred to overexpress tau—a toxic protein that builds up in the neurons of people with Alzheimer’s and several other neurodegenerative diseases—getting rid of the T cells stemmed tissue loss and preserved the mice’s cognition, even as tau kept building up.

Now, the same group has explored what prompts these cells to wreak havoc in the brain. In a mouse study published last week in Nature Neuroscience, Holtzman and immunology researcher Hao Hu, both at Washington University in St. Louis, report that immune cells in the lymph nodes of the neck instruct the T cells to clone themselves before they enter the brain. Without them, the mice had far fewer cloned T cells inside their brains and experienced less neurodegeneration. The study is “beautiful work,” says neuroscientist Kenneth Kosik of the University of California, Santa Barbara, who studies tau but was not involved in the research. It also suggests that existing drugs, developed for other conditions, might work in Alzheimer’s by shielding the brain from the destructive cells.

New pulse-train method aims to improve precision in quantum control

Quantum technologies are poised to transform fields ranging from medicine and sensing to computing and communications by manipulating the energy states of atoms and molecules. These manipulations are achieved by controlling quantum states with laser pulses.

However, the intense laser fields often required for this control can cause unwanted effects that disrupt the very system they aim to manipulate.

Now, Stevens researchers and their collaborators have developed a novel method that enables precise control of quantum systems without these undesirable effects.

AI could soon infer human intent by sensing “that’s not what I meant” through neural feedback

A future in which AI can recognize a person’s unspoken “that’s not what I meant” response from brain signals and adjust its behavior on its own is coming closer. KAIST researchers have developed a technology that detects cognitive mismatch between humans and AI through brainwaves, enabling AI systems to revise their actions in real time according to human goals. The achievement is expected to accelerate the shift from AI that follows explicit commands to AI that can infer human intent.

A research team led by Endowed Chair Professor Sang Wan Lee from the Department of Brain and Cognitive Sciences (Director of the Center for Neuroscience-Inspired Artificial Intelligence), in collaboration with Microsoft Research Asia (MSRA), developed Neural Value Alignment (NVA), a next-generation brain–computer interface (BCI) technology.

The research is published in IEEE Transactions on Cybernetics.

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