An Anthropic model cut the work needed to break a leading post-quantum signature candidate by a factor of 67 million last month, while Bitcoin and Ethereum published their own migration plans this week.
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The New Urgency of Protecting Critical Infrastructure
Dear Readers, The latest of the Security & Tech Insights newsletter covers the domain of protecting critical infrastructure and its urgency.
Protecting critical infrastructure is not optional—it is a strategic imperative for national security, economic stability, and public safety. The grid, water, transportation, space, and other sectors are deeply interconnected and interdependent, with their failure or disruption having cascading effects across multiple domains. And the threat landscape is evolving rapidly. Legacy operational technologies and industrial control systems, once isolated, are now connected to IT networks, the internet, and the Internet of Things, creating exponentially more entry points for attackers.
A startup claims it’s found a drug to make your blood young
The Conboys are back in the news. What they did before needed a blood transfusion to filter out blood factors and replace a part of your blood with saline solution and a protein called albumin. Now they say a drug combo can do the same thing and are going to a 100 person study.
Generation Lab claims its drug combo can “stop the spread of aging” around the body. And it’s looking for influencers to give it a try.
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Amino acid metabolism rewiring leads to hormone therapy resistance in prostate cancer
Prostate tumors can rewire amino acid metabolism to override the normal brakes on cholesterol production, a process that may fuel hormone therapy resistance, according to a new study.
The preclinical study, published in Nature Metabolism, revealed that a compound called propionyl-CoA, produced by the breakdown of amino acids isoleucine and valine during normal energy metabolism, acts as a signal that switches on cholesterol production. This helps prostate cancer cells adapt to the hormone-deprived conditions resulting from treatment and acquire more aggressive features.
By revealing this previously unrecognized connection, the study identified a potential weakness in prostate cancer that could be targeted with new drugs or, pending clinical testing, dietary strategies that reduce levels of isoleucine and valine. These essential amino acids are abundant in protein-rich foods such as meat, fish and dairy products.
TRANQUILITY: Sustained Reductions in Inflammatory Markers in CKD Patients With Pacibekitug
Pacibekitug, a novel, long-acting monoclonal antibody that targets interleukin-6, produced sustained reductions in inflammatory markers in patients with chronic kidney disease (CKD) and at high inflammatory risk, with no clear dose-related safety signals identified, based on findings from the TRANQUILITY study presented at ESC Congress 2026.
Researchers for the phase II study conducted at 49 centers in the U.S., randomized (1:1:1:1) at total of 143 patients with stage 3–4 CKD and elevated high-sensitivity C-reactive protein (hs-CRP) to receive subcutaneous pacibekitug at doses of 25 mg every 90 days; 50 mg every 90 days; 15 mg every 30 days; or placebo for six months. The mean age of study participants was 69 years and 64% were women. Roughly 70% were on statins and 60% had diabetes.
Overall results showed pacibekitug treatment resulted in dose-dependent decreases in hs-CRP by day 30, which were sustained through day 180. Deepak Bhatt, MD, MPH, MBA, FACC, from the Icahn School of Medicine at Mount Sinai in New York, reported that median time-averaged change from baseline in hs-CRP through day 180 was +7% with placebo; −76% with pacibekitug 25 mg every 90 days; −85% with pacibekitug 50 mg every 90 days; and −89% with pacibekitug 15 mg every 30 days (all p0.0001 vs. placebo).
REACT: Use of Imaging to Detect Silent Atherosclerosis in Early Adulthood
Silent atherosclerosis is detectable using imaging in early adulthood, with age-and sex-associated increases in prevalence across arterial territories and significant increases in plaque volume, based on results from the REACT trial presented at ESC Congress 2026 and simultaneously published in NEJM. The findings suggest the use of imaging from early adulthood “may provide an opportunity to improve primary prevention strategies and reduce the substantial burden of atherosclerotic cardiovascular disease,” researchers said.
REACT enrolled nearly 17,000 adults without known atherosclerotic cardiovascular disease (mean age 45; 51% women) from Denmark and Spain and placed them in five prespecified age strata that included a balanced number of men and women. Three-dimensional vascular ultrasonography of the carotid and femoral arteries, as well as coronary computed tomographic angiography (CCTA), were used to asses silent atherosclerosis at baseline.
Overall findings showed silent atherosclerosis was present in 57% of all the participants. Broken down by age, atherosclerosis was present in nearly 9% of men and 7% of women in the youngest age stratum (18 to 29 years), with prevalence increasing with age. Approximately 9 out of 10 individuals between the ages of 60 and 70 had atherosclerosis, researchers said.