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Nov 25, 2024

Comparative prospects of imaging methods for whole-brain mammalian connectomics

Posted by in categories: nanotechnology, neuroscience

Neuroscience aficionados may enjoy my preprint that compares leading imaging technologies for whole-brain mammalian connectomics, now with major updates/improvements: Link: arxiv.org/abs/2405.


Mammalian whole-brain connectomes at nanoscale synaptic resolution are a crucial ingredient for holistic understanding of brain function. Imaging these connectomes at sufficient resolution to densely reconstruct cellular morphology and synapses represents a longstanding goal in neuroscience. Although the technologies needed to reconstruct whole-brain connectomes have not yet reached full maturity, they are advancing rapidly enough that the mouse brain might be within reach in the near future. Detailed exploration of these technologies is warranted to help plan projects with varying goals and requirements. Whole-brain human connectomes remain a more distant goal yet are worthy of consideration to orient large-scale neuroscience program plans. Here, we quantitatively compare existing and emerging imaging technologies that have potential to enable whole-brain mammalian connectomics.

Nov 25, 2024

Global Photonics Engineering Contest

Posted by in categories: computing, engineering

Early Bird Opportunity in the Global Photonics Engineering Contest.
: All submissions received by 31st December 2024, will receive personalized feedback from Photon Delta engineers.

Submit your application now: https://wevlv.co/photondelta-s.

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Nov 25, 2024

Gary Numan, I Dream Of Wires (Extended Mix)

Posted by in category: cyborgs

I dream of wires cyborgization 2050 CE.


Gary Numan I Dream Of Wires (Extended Mix) Well what else can I say, I Dream Of Wires is a stunning track. I love it and I have tried to do a stunning Extended mix of it. Again, from the stunning early Gary Numan album Telekon.

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Nov 25, 2024

Plasma pursuits: HEDS Center fellows illuminate the fourth state of matter

Posted by in categories: energy, physics

In 2019, the High Energy Density Science (HEDS) Center at Lawrence Livermore National Laboratory (LLNL) launched its postdoctoral fellowship program, welcoming one new scientist annually to come and conduct research for a two-year term. Supported by LLNL’s Weapons Physics and Design program, HEDS fellows are encouraged to pursue their own research agenda as it relates to the study of matter and energy under extreme conditions.

The most recent postdoctoral fellows, physicist Elizabeth “Liz” Grace (2022 fellow) and plasma physicist Graeme Sutcliffe (2023 fellow), are using high-intensity lasers and advanced diagnostics to observe the behaviors of plasma. A plasma, known as the “fourth state of matter,” is a superheated, ionized gas that makes up the majority of visible matter in the universe, like stars and nebulae. Replicating these conditions is a key step to achieving robust igniting inertial fusion designs for energy resilience.

Nov 25, 2024

The Thrill and Threat of Mind Hacking | Posthuman with Emily Chang

Posted by in categories: biotech/medical, business, cybercrime/malcode, finance, neuroscience, wearables

From brain implants that allow paralyzed patients to communicate to the wearable devices enhancing our capabilities, brain-computer interfaces could change the way we use our minds forever.

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Nov 25, 2024

The illusionist View of Consciousness

Posted by in category: neuroscience

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Nov 25, 2024

China develops new stealth coating to blind anti-stealth radars

Posted by in categories: materials, military

The Chinese military claims it has developed a new radar-defeating coating that can hide targets from anti-stealth radar.


According to the Chinese researchers, their new technology provides exceptional ultra-wideband low-frequency stealth capabilities without relying on heavy and costly magnetic materials.

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Nov 25, 2024

RTX’s Raytheon awarded U.S. Army contract for wireless power beaming technology

Posted by in categories: business, robotics/AI

Work is being conducted as part of a…


Technology will extend operational reach and counter autonomous systems

EL SEGUNDO, Calif., Nov. 14, 2024 /PRNewswire/ — Raytheon, an RTX (NYSE: RTX) business, has been awarded a contract from the U.S. Army to work on directed energy wireless power beaming capabilities that will distribute power across the battlefield, simplify logistics, and safeguard locations for U.S. troops.

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Nov 25, 2024

Early adult binge drinking has lasting impact on aging brain in mice

Posted by in categories: bioengineering, biotech/medical, chemistry, life extension, neuroscience

In a new work, a team from the University of Pennsylvania tracked the impact of alcohol consumption from the age of 20 on brain health and came to disappointing conclusions.


UNIVERSITY PARK, Pa. — Binge drinking in early adults can lead to long-lasting and potentially permanent dysregulation in the brain, according to a new study in mice, led by researchers at Penn State. They found that neurons, cells that transmit information in the brain via electrical and chemical signals, showed changes following binge drinking were similar in many ways to those seen with cognitive decline.

These findings, published in the journal Neurobiology of Aging, reveal that binge drinking early in life may have lasting impacts that are predictive of future health issues, like Alzheimer’s disease and related dementias, the researchers said. The work could inform the development of therapeutics to help combat these changes — particularly in aging populations who may have given up alcohol decades earlier, according to Nikki Crowley, director of the Penn State Neuroscience Institute at University Park, Huck Early Career Chair in Neurobiology and Neural Engineering, assistant professor of biology in the Eberly College of Science, and the leader of the research team.

Continue reading “Early adult binge drinking has lasting impact on aging brain in mice” »

Nov 25, 2024

New Platform Overcomes Blood-Brain Barrier for Drug Delivery

Posted by in categories: biotech/medical, neuroscience

Summary: Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier. The innovative blood-brain barrier-crossing conjugate (BCC) platform utilizes a biological process called γ-secretase-mediated transcytosis to safely transport drugs like oligonucleotides and proteins into the central nervous system via intravenous injection.

In mouse models and human brain tissue, the system effectively silenced harmful genes linked to diseases such as ALS and Alzheimer’s without causing significant side effects. This advancement could revolutionize treatments for neurological and psychiatric disorders, solving a critical challenge in brain research.

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