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Major depression, obesity and chronic pain are all linked to the effects of one protein, called “FK506-binding protein 51,” or FKBP51. Until now, efforts to inhibit this target have been hampered by the difficulty of finding something specific enough to do the job and not affect similar proteins. Now a research group has developed a highly selective compound that can effectively block FKBP51 in mice, relieving chronic pain and having positive effects on diet-induced obesity and mood. The new compound also could have applications in alcoholism and brain cancer.


It sounds like the start of a very bad physics riddle: I’m a particle that really isn’t; I vanish before I can even be detected, yet can be seen. I break your understanding of physics but don’t overhaul your knowledge. Who am I?

It’s an odderon, a particle that’s even more odd than its name suggests, and it may have recently been detected at the Large Hadron Collider, the most powerful atom smasher, where particles are zipped at near light speed around a 17-mile-long (27 kilometers) ring near Geneva in Switzerland.

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The wings of aircraft today are complex systems with lots of moving flaps and components controlled by hydraulics or cables depending on the application. Researchers from NASA and MIT have shown off a new wing design that is flexible and able to change shape to control the flight. The team says that the new design could significantly boost aircraft production, flight, and improve maintenance efficiency.

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To develop a new method of underwater plasma generation, scientists used 3D printing to replicate the shape of a snapping shrimp claw and the complex way it works.

As reported in Science Advances, the discovery could lead to significant improvements in the development of water sterilization, drilling, and more.

When the snapping shrimp—also known as the pistol shrimp—snaps its claw, it shoots out a jet of water fast enough to generate a bubble which, when it collapses, creates a loud noise and emits light. The high pressures and temperatures produced in this process lead to plasma formation.

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(Originally posted March 7, 2019, on the Crowdfunding Professional Association’s website.)

The purpose of this memo is two-fold:

  • To highlight the possibility of risks to banking and finance sectors arising from new financial instruments based on blockchain technology; primarily from novel financial accounting methods and products called “stablecoins,” digital tokens, and cryptocurrencies.
  • To encourage regulators and policymakers to engage blockchain thought leaders, product developers and the community in general to better understand the economic and policy implications of public, private and permissioned blockchains; their application to banking and finance regulations; and how innovation may be encouraged in a safe, sound and responsible manner.

Wang and his colleagues found that many cancers that get switched into overdrive and boost tumor growth have jumping genes that function as a kind of stealthy “on switch.” These cryptic switches can force a gene to be turned on all the time, even though it should be off.


Mistakes in DNA are known to drive cancer growth. But a new study, from Washington University School of Medicine in St. Louis, heavily implicates a genetic phenomenon commonly known as “jumping genes” in the growth of tumors.

The study is published March 29 in the journal Nature Genetics.

Since jumping genes aren’t mutations—mistakes in the letters of the DNA sequence—they can’t be identified by traditional cancer genome sequencing. As such, this study opens up new lines of research for future cancer therapies that might target such genes.