Lifeboat Foundation: Safeguarding Humanity
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The Human Genome Project is probably the most ambitious scientific proposal ever made.

ii. writing DNA

Synthesising short, single stranded fragments of DNA, called oligonucleotides (oligos for short) has been automated and affordable for a number of years now, and almost every biology laboratory in the world uses these short fragments (usually 18–25 base-pairs — compare this to the human genome which is 3 billion base-pairs long) for applications ranging from disease diagnostics to making genetically modified plants. What really has been a game-changer in DNA synthesis is the ability to synthesise longer pieces of DNA and the ability to join these together efficiently to form synthetic gene length fragments.

Continue reading “Writing Our Genome” | >

How close are we to creating a synthetic human genome?

Creating humans is also an ethical minefield. Unsettled questions about who might own a synthetic human genome abound. Boeke warns that ownership could come down to who ends up funding the project development. Rob Carlson, a co-author of the GP-Write proposal, is even more skeptical of the idea of a patented artificial human genome, pointing out via email that “as soon as there is any possibility of a synthetic genome being used to germinate a live human, then ownership is obviously out of the question anyway…because you are now talking about owning a person.”

So far the GP-write project has been more talk than action, with large consultation meetings held between scientists and policy experts. The project has yet to attract significant funding. Perhaps successes in other organisms like yeast will embolden governments and private industry to open up to the idea of a man-made human genome.

Continue reading “Synthetic genomics – Inside the effort to create entire genomes from scratch” | >

Afghanistan’s first-ever robot waitress glides up to a table of curious diners in central Kabul and presents them with a plate of French fries.

“Thank you very much,” the machine says in Dari, one of Afghanistan’s two main languages.

Restaurant manager Mohammad Rafi Shirzad says the humanoid robot, imported from Japan and designed to look vaguely like a women wearing a hijab, has already pulled in new customers since it started working last month.

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Newborn screening covers more than 30 conditions. Yet, with genome sequencing, we could screen newborns for several thousand genetic conditions.

In the surveys’ open-ended responses about risks of genome sequencing, parents and clinicians both expressed concerns about psychological distress related to difficult or uncertain results. Clinicians were more likely to raise concerns about returning results for adult-onset conditions, unnecessary parental stress over health problems that might never actually occur, and the possibility of future discrimination against the child on the basis of their genomic information.

On the other hand, parents mentioned a broader range of benefits than clinicians. Both parents and clinicians saw potential health benefits of genome sequencing, such as the ability to search for more conditions compared to standard newborn screening and the ability to predict a child’s future disease risks. Parents went further, though, seeing benefits in family planning, preparing for the child’s future, and knowledge just for the sake of knowing. Those potential benefits fall outside of traditional definitions of clinical utility, which means they are less likely to be considered in the professional guidelines that steer adoption of practices like genome sequencing.

Continue reading “Is It Too Soon to Consider Genome Sequencing for Newborns?” | >

Superb piece.

“But, I say we should pursue science and technology because, like Prometheus, the fires of invention burn bright, and although we may not always know where it leads us, a world darkened by the fear of treading upon the unknown, is unimaginable.”

Yet we can look to a brighter side, one I could never have imagined in the ’60’s when the chromosomes we karyotyped would be uncoiled to lay bare the genome as an instrument for critical medical diagnoses, to set free those erroneously convicted of crime, or enlighten us about Mitochondrial Eve our common mother, and the long journey that began two hundred thousand years ago; the journey that brought me into the world of physical things, air, table and chairs, and beyond into the space of the geometries and cohorts, like Golay and Bolsey, who helped me better understand my Universe, the one either too small or too far to see, unless aided by the eyes of science and technology. I once wondered how I got here, and now I think I know, but I am afraid my second query, “where will it lead,” will remain an open question.

Continue reading “We cannot predict with any precision where technology will lead us” | >

An auditory illusion thought to synchronize brain waves and alter mood is no more effective than other sounds, according to research in adults recently published in eNeuro. The effect reported in other studies might be a placebo but could still have helpful effects for some people.

Binaural beats are an auditory illusion caused by listening to two tones of slightly different frequency, one in each ear. The difference in frequencies creates the illusion of a third sound — a rhythmic beat. Neurons throughout the brain begin to send electrical messages at the same rate as the imaginary beat. Many unsupported claims surround binaural beats, including that listening to them decreases anxiety, increases focus, and improves mood.

Orozco Perez et al. played binaural and monoaural beats to healthy adults and measured their brain activity with electroencephalography. Monoaural beats don’t rely on the illusion to create the beats because they consist of edited audio tracks of the two different tones together. Both ears hear all three sounds. Brain activity synchronized with both types of beats, but the effect was stronger with monoaural beats. Neither type of beat affected mood. When the binaural beat played, far apart brain areas synchronized with each other at a different frequency than the beat. This may be how binaural beats improve memory and focus.

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HUNTSVILLE, Ala. — Blue Origin formally opened a factory Feb. 17 that the company plans to use to produce engines both for its vehicles and for United Launch Alliance’s Vulcan rocket.

A ribbon-cutting ceremony marked the completion of a 350,000-square-foot factory here that will produce BE-4 and BE-3U engines. The factory, built in a little more than a year, will host more than 300 employees and produce up to 42 engines a year.

“You can see we can get some things done really quickly,” said Bob Smith, chief executive of Blue Origin, in remarks at the ceremony. “Twelve months to actually build this kind of facility is an amazing accomplishment for our team.”

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