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Researchers at the Institut Pasteur in France have become the second monitoring team in the world to sequence the entire novel coronavirus (2019-nCoV) genome in an effort to better understand its origin and virulent properties.

Nearly 8,000 reported cases and hundreds of deaths have been reported in at least 19 countries since the outbreak began in Wuhan, China, last December, prompting the World Health Organization yesterday to declare a public health emergency after evidence of human-to-human transmission had surfaced. International healthcare experts have since prioritized research surrounding 2019-nCoV in an effort to understand and tame the global outbreak.

“Sequencing the genome of pathogens is crucial for the development of specific diagnostic tests and the identification of potential treatment options,” explained Sylvie van der Werf, director of the National Reference Center (CNR) for Respiratory Viruses at the Institut Pasteur, in a statement.

Researchers at the National Institutes of Health are working with biotech company Moderna Therapeutics to develop and test a vaccine against the latest viral outbreak.

NASA’s Chandra X-Ray Observatory is altering our perspective on the cosmos — and it is beautiful.

Here’s a look back at our coverage of Columbia’s final mission, the tragic loss of seven astronauts, and the investigation into the cause of the accident: https://spaceflightnow.com/shuttle/sts107/

Circa 2017 Bats harbor a large diversity of coronaviruses (CoVs), several of which are related to zoonotic pathogens that cause severe disease in humans. Our screening of bat samples collected in Kenya from 2007 to 2010 not only detected RNA from several novel CoVs but, more significantly, identified sequences that were closely related to human CoVs NL63 and 229E, suggesting that these two human viruses originate from bats. We also demonstrated that human CoV NL63 is a recombinant between NL63-like viruses circulating in Triaenops bats and 229E-like viruses circulating in Hipposideros bats, with the breakpoint located near 5′ and 3′ ends of the spike (S) protein gene. In addition, two further interspecies recombination events involving the S gene were identified, suggesting that this region may represent a recombination “hot spot” in CoV genomes. Finally, using a combination of phylogenetic and distance-based approaches, we showed that the genetic diversity of bat CoVs is primarily structured by host species and subsequently by geographic distances.

^bMarie Bashir Institute for Infectious Diseases and Biosecurity, Charles Perkins Centre, School of Life and Environmental Sciences and Sydney Medical School, The University of Sydney, Sydney, Australia.

Find articles by Mang Shi

Continue reading “Surveillance of Bat Coronaviruses in Kenya Identifies Relatives of Human Coronaviruses NL63 and 229E and Their Recombination History” »

Uber-flying-car-2020.

Uber aims to prove once again its intention to stay at the crest of innovation with the latest updates of its flying car concept, which it plans to launch by 2020.

Continue reading “This awesome Uber flying car concept may become reality by 2020” »

If you are interested in superlongevity, then I have something that you must read. I have previously recommended a book by Dr. David Sinclair called Lifespan. Here I am recommending a research paper that discusses one of the critical experiments in epigenetic age reversal. Normally I would read a paper first before recommending it. However, I think this is a blockbuster, and it’s over 50 pages, so I can’t wait till my slow eyes finish before passing this on. Here is an excerpt:

Age reversal!

The primary research scientist is Yuancheng Lu.

Continue reading “Reversal of ageing- and injury-induced vision loss” »

Scientists studied 17,308 human brains from the UK Biobank to see how alcohol affects brains. The brain ages one week per drinking session.

Surprising findings could springboard the development of new anticancer drugs, or potentially even directly repurpose existing drugs for cancer therapy.

Drugs that are currently used to treat a wide range of conditions such as diabetes, inflammation, alcoholism, and even canine arthritis, can also kill laboratory-grown cancer cells, according to the results of a study by scientists at the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute. Using a molecular barcoding technology called PRISM (profiling relative inhibition simultaneously in mixtures) the researchers were able to screen thousands of existing drug compounds against different types of cancer cell lines. The results identified 49 compounds with previously unrecognized anticancer activity. The researchers say their surprising findings, which highlighted novel anticancer mechanisms and targets, could feasibly be used to springboard the development of new anticancer drugs, or potentially even directly repurpose existing drugs for cancer therapy.

Continue reading “Anticancer Activity Discovered in Dozens of Existing Noncancer Drugs” »