Lifeboat Foundation: Safeguarding Humanity
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Probiotics help prevent some infections in this study.

However, relatively little is known about the mechanisms used by Listeria to cross the intestinal barrier. Understanding more about the way Listeria spreads around the body would allow us to consider strategies for preventing infection in high-risk populations.

At Purdue University in Indiana, USA, Professor Arun Bhunia, Dr Rishi Drolia and the team are researching the mechanisms of pathogenesis (development of disease) used by Listeria to enter the bloodstream.

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Seeing the environmental crises rising particularly because of the construction sector, more conscious choices regarding building materials need to be considered. Since the beginning of our craft, architects and constructors have been trying to utilize natural materials in buildings—either used in their raw form, like bamboo, or processed and incorporated into different materials. Hempcrete is one type of concrete incorporating natural materials; it is energy-saving and durable.

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Dean’s appearance at TED comes during a time when critics—including current Google employees —are calling for greater scrutiny over big tech’s control over the world’s AI systems. Among those critics was one who spoke right after Dean at TED. Coder Xiaowei R. Wang, creative director of the indie tech magazine Logic, argued for community-led innovations. “Within AI there is only a case for optimism if people and communities can make the case themselves, instead of people like Jeff Dean and companies like Google making the case for them, while shutting down the communities [that] AI for Good is supposed to help,” she said. (AI for Good is a movement that seeks to orient machine learning toward solving the world’s most pressing social equity problems.)

TED curator Chris Andersen and Greg Brockman, co-founder of the AI ethics research group Open AI, also wrestled with the unintended consequences of powerful machine learning systems at the end of the conference. Brockman described a scenario in which humans serve as moral guides to AI. “We can teach the system the values we want, as we would a child,” he said. “It’s an important but subtle point. I think you do need the system to learn a model of the world. If you’re teaching a child, they need to learn what good and bad is.”

There also is room for some gatekeeping to be done once the machines have been taught, Anderson suggested. “One of the key issues to keeping this thing on track is to very carefully pick the people who look at the output of these unsupervised learning systems,” he said.

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Since receiving a $25 million grant in 2,019 to become the first National Science Foundation (NSF) Quantum Foundry, UC Santa Barbara researchers affiliated with the foundry have been working to develop materials that can enable quantum information-based technologies for such applications as quantum computing, communications, sensing, and simulation.

They may have done it.

In a new paper, published in the journal Nature Materials, foundry co-director and UCSB professor Stephen Wilson and multiple co-authors, including key collaborators at Princeton University, study a new material developed in the Quantum Foundry as a candidate superconductor—a material in which electrical resistance disappears and magnetic fields are expelled—that could be useful in future quantum computation.

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Researchers from the group of Hans Clevers (Hubrecht Institute) corrected mutations that cause cystic fibrosis in cultured human stem cells. In collaboration with the UMC Utrecht and Oncode Institute, they used a technique called prime editing to replace the ‘faulty’ piece of DNA with a healthy piece. The study, published in Life Science Alliance on August 9 shows that prime editing is safer than the conventional CRISPR/Cas9 technique. “We have for the first time demonstrated that this technique really works and can be safely applied in human stem cells to correct cystic fibrosis.”

Cystic fibrosis (CF) is one of the most prevalent genetic diseases worldwide and has grave consequences for the patient. The mucus in the lungs, throat and intestines is sticky and thick, which causes blockages in organs. Although treatments are available to dilute the mucus and prevent inflammations, CF is not yet curable. However, a new study from the group of Hans Clevers (Hubrecht Institute) in collaboration with the UMC Utrecht and Oncode Institute offers new hope.

Correcting CF mutations

The researchers succeeded in correcting the that cause CF in human intestinal organoids. These organoids, also called mini-organs, are tiny 3D structures that mimic the intestinal function of patients with CF. They were previously developed by the same research group from stem cells of patients with CF and stored in a biobank in Utrecht. For the study, published in Life Science Alliance, a technique named prime editing was used to replace the piece of mutated DNA that causes CF with a healthy piece of DNA in these organoids.

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Caffeinated coffee might be protective to overall health, but so is decaf. For example, a 2,019 systematic review published in the Journal of Human Nutrition and Dietetics aiming to “investigate the association of caffeinated and decaffeinated coffee consumption and all-cause mortality” found “similar inverse associations [between] caffeinated coffee and decaffeinated coffee [and all-cause mortality.]”

But is coffee healthy? And do coffee drinkers live longer than non-coffee drinkers?

At the turn of the 20th century, it was considered common knowledge that coffee was unhealthy—there were advertising claims that coffee drinking caused blindness and that “you can recover from any ordinary disease by discontinuing coffee.” And while that may obviously be untrue, there are continuing fears about whether coffee is actually healthy or not. Google receives 4,400 queries a month about” why coffee is bad for you” (for context, “why coffee is good for you” gets only 1,300 queries a month).

So with human life extension in mind, I decided to dig into the research. Can coffee consumption actually help spanners extend their healthspan and lifespan? How much is the right dose? How much is too little?

Continue reading “Do Coffee Drinkers Live Longer?” | >

For several years, Lu’s lab has been working on ways to use DNA to store information such as memory of cellular events. In 2,014 he and Farzadfard developed a way to employ bacteria as a “genomic tape recorder,” engineering E. coli to store long-term memories of events such as a chemical exposure.

Technique for editing bacterial genomes can record interactions between cells, may offer a way to edit genes in the human microbiome.

Biological engineers at MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances.

Continue reading “MIT Researchers Devised a Way To Program Memories Into Bacterial Cells” | >