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Chang and Jain develop a genetically encoded reporter to measure polyamines at single-cell resolution in C. elegans. By mapping polyamine control across tissues and development, they uncover organizing principles of in vivo polyamine regulation, including widespread reliance on transport and a central role for the intestine in coordinating systemic homeostasis.
Research and development of fusion energy has recently gained a strong impetus from private investment. While less of a proliferation risk than conventional fission systems, modified fusion systems could produce material usable in nuclear weapons. This paper examines an innovative use of antineutrino detectors to find misuse of fusion systems. Since antineutrinos are so penetrating, this technique carries near-zero interference with fusion energy system operation.
Therapy resistance is a major obstacle to durable clinical responses. While genetic alterations and signalling rewiring are primary drivers of resistance, metabolic adaptation, which is closely intertwined with these processes, enables tumour persistence under therapeutic pressure and directly contributes to resistance. Peroxisomes are metabolic organelles with a role in controlling lipid metabolism, together with redox signalling and homeostasis—processes that intersect with pathways governing cancer behaviour and therapy response. Indeed, peroxisomal functions are remodelled to support metabolic plasticity and redox buffering under therapeutic stress.