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A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes—demonstrated successfully in living mouse models that are blind due to a mutation.

This system also holds promise for advancing by enabling precise genetic manipulation of engineered , making them more universally compatible and thus more accessible for a larger group of cancer patients.

The work is published in the journal Cell.

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Recently, a team of researchers from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences (CAS) consecutively removed the innermost atom and the outermost electron of a gold nanoparticle—without disturbing its overall structure. This precise manipulation allowed them to probe how the magnetic spin of the material influences its catalytic activity.

The work, led by Prof. Wu Zhikun in collaboration with Prof. Yang from the Institute of Process Engineering, CAS and Prof. Tang from Chongqing University, was published in Science Advances.

Gold nanoclusters—tiny particles composed of from a few to hundreds of —are ideal models for studying how atomic structure affects . But tuning the structure of such clusters atom by atom, especially when they’re relatively large and complex, has long been a major challenge.

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I wish for all òf us we the living and we that’s yet to be.

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Health care providers can use small devices to hover over moles or lesions and immediately check for common skin cancers, such as melanoma and basal cell carcinoma.

The most significant benefit is that health care professionals who do not specialize in dermatology could perform these checks during a routine visit, making early detection easier and quicker.

Skin cancer is the most common form of cancer in the United States, with one in five Americans expected to be affected in their lifetime, according to the City of Hope Cancer Center.

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For generations, sailors around the globe have reported a mysterious phenomenon: Vast areas of the ocean glow steadily at night, sometimes for months on end. The light is bright enough to read by and is oddly similar to the green and white aura cast by glow-in-the-dark stars that have decorated children’s rooms. Stretching over ocean space as broad as 100,000 square kilometers, the light can, at times, even be seen from space.

This rare bioluminescent display was coined by sailors as “milky seas.” Despite being encountered for centuries, scientists still know very little about what causes this glowing effect because they are quite rare—they usually occur in the remote regions of the Indian Ocean, far from human eyes. A likely theory is that the glow comes from activity by a luminous microscopic bacteria called Vibrio harveyi.

To better predict when milky seas will occur, researchers at Colorado State University have compiled a database of sightings over the last 400 years.

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A research team has successfully fine-tuned the Rabi oscillation of polaritons, quantum composite particles, by leveraging changes in electrical properties induced by crystal structure transformation. Published in Advanced Science, this study demonstrates that the properties of quantum particles can be controlled without the need for complex external devices, which is expected to greatly enhance the feasibility of practical quantum technology. The team was led by Professor Chang-Hee Cho from the Department of Physics and Chemistry at DGIST.

Quantum technology enables much faster and more precise information processing than conventional electronic devices and is gaining attention as a key driver of future industries, including quantum computing, communications, and sensors. At the core of this technology lies the ability to accurately generate and control quantum states. In particular, recent research has been actively exploring light-based quantum devices, with polaritons at the center of this field.

Polaritons are composite quasiparticles formed through the hybridization of photons and excitons—bound states arising from the motion of electrons. These quasiparticles travel at the speed of light while retaining the ability to interact with other particles, much like electrons.

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By Bruce Goldman

Stanford Medicine scientists have rebuilt, in laboratory glassware, the neural pathway that sends information from the body’s periphery to the brain, promising to aid research on pain disorders.

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Thanks to a mouse watching clips from “The Matrix,” scientists have created the largest functional map of a brain to date—a diagram of the wiring connecting 84,000 neurons as they fire off messages.

Using a piece of that mouse’s brain about the size of a poppy seed, the researchers identified those neurons and traced how they communicated via branch-like fibers through a surprising 500 million junctions called synapses.

The massive dataset, published Wednesday by the journal Nature, marks a step toward unraveling the mystery of how our brains work. The data, assembled in a 3D reconstruction colored to delineate different brain circuitry, is open to scientists worldwide for additional research—and for the simply curious to take a peek.

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Identifying rare microorganisms in microbiome data just got easier. A team of researchers from Portugal and Canada has developed a new tool that uses machine learning to automatically detect rare biosphere in ecological datasets.

The aim is to quickly, autonomously and unsupervisedly identify rare microorganisms in microbiome datasets. This new tool, named ulrb, responds to a long-standing challenge in : distinguishing rare microorganisms from the most abundant in natural environments.

The new methodology and the new ulrb software have now been published in the study “Definition of the microbial rare biosphere through unsupervised machine learning” in the journal Communications Biology.

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