Researchers have identified a neurochemical signature that sets Parkinson’s disease apart from essential tremor — two of the most common movement disorders, but each linked to distinct changes in the brain.

In a new study in Nature Communications, scientists identified unique chemical signaling patterns of two key neurotransmitters — dopamine and serotonin — that distinguish these two disorders.

“This study builds on decades of work,” said a co-senior author, who with colleagues developed the multi-faceted technologies and the theoretical constructs for the work over their 15 years at the research institute.