NASA’s Solar Dynamics Observatory has confirmed that a massive solar flare has erupted from an Earth-facing sunspot on October 28.
Researchers at MIT and Harvard University have designed a way to selectively turn on gene expression in target cells, including human cells. Their technology can detect specific mRNA sequences (represented in the center of the illustration), which triggers production of a specific protein (bottom right). Credit: Jose-Luis Olivares, MIT, with figures from iStockphoto.
“This brings new control circuitry to the emerging field of RNA therapeutics, opening up the next generation of RNA therapeutics that could be designed to only turn on in a cell-specific or tissue-specific way,” says James Collins, the Termeer Professor of Medical Engineering and Science in MIT’s Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering and the senior author of the study.
This highly targeted approach, which is based on a genetic element used by viruses to control gene translation in host cells, could help to avoid some of the side effects of therapies that affect the entire body, the researchers say.
Even when there’s not a cloud in the sky, there’s always water circulating in the atmosphere.
Compared to all the H20 on Earth, there isn’t much up there – only about 0.001 percent – but in areas of high humidity, even that small amount of moisture could be enough to provide safe drinking water for a billion people.
The hydration is there for the taking. All we need to do is figure out how to get it.
A commonly available oral diuretic pill approved by the U.S. Food and Drug Administration may be a potential candidate for an Alzheimer’s disease treatment for those who are at genetic risk, according to findings published in Nature Aging. The research included analysis showing that those who took bumetanide — a commonly used and potent diuretic — had a significantly lower prevalence of Alzheimer’s disease compared to those not taking the drug. The study, funded by the National Institute on Aging (NIA), part of the National Institutes of Health, advances a precision medicine approach for individuals at greater risk of the disease because of their genetic makeup.
The research team analyzed information in databases of brain tissue samples and FDA-approved drugs, performed mouse and human cell experiments, and explored human population studies to identify bumetanide as a leading drug candidate that may potentially be repurposed to treat Alzheimer’s.
“Though further tests and clinical trials are needed, this research underscores the value of big data-driven tactics combined with more traditional scientific approaches to identify existing FDA-approved drugs as candidates for drug repurposing to treat Alzheimer’s disease,” said NIA Director Richard J. Hodes, M.D.
This was described in his 2019 paper, “The mass-energy-information equivalence principle,” which extends Einstein’s theories about the interrelationship of matter and energy to data itself. Consistent with IT, Vopson’s study was based on the principle that information is physical and that all physical systems can register information. He concluded that the mass of an individual bit of information at room temperature (300K) is 3.19 × 10-38 kg (8.598 × 10-38 lbs).
Taking Shannon’s method further, Vopson determined that every elementary particle in the observable Universe has the equivalent of 1.509 bits of encoded information. “It is the first time this approach has been taken in measuring the information content of the universe, and it provides a clear numerical prediction,” he said. “Even if not entirely accurate, the numerical prediction offers a potential avenue toward experimental testing.”
While the Hubble Space Telescope ages, the James Webb Telescope prepares to launch.
With the aging Hubble space telescope experiencing another malfunction, how does the venerable telescope compare with its soon to the forthcoming James Webb?
Universal covid vaccine works well in chimps human trails next. #COVID19 #cure
Immunization of macaques with nanoparticle-conjugated receptor-binding domain of SARS-CoV-2 adjuvanted with 3M-052 and alum results in cross-neutralizing antibodies against bat coronaviruses, SARS-CoV and SARS-CoV-2 variants, and may provide a platform for developing pan-coronavirus vaccines.
It is challenging to store the exponentially increasing amount of data in the information age. The multiplexed optical data storage with merits of high data density (hundreds of terabytes/disk), low energy consumption, and long lifetime could open a new era in data storage technology. The recent progress in five-dimensional (5D) optical data storage based on anisotropic nanostructures written by femtosecond (fs) laser pulses in transparent materials reveals its potential for real-world applications, but high writing speed and density remain a major challenge. Here, we propose a method for rapid and energy-efficient writing of highly localized anisotropic nanostructures in silica glass by energy modulated megahertz-rate fs pulses. An isotropic nanovoid is initially generated with pulse energy above the microexplosion threshold and then elongated to an anisotropic nanolamella-like structure via the near-field enhancement effect by lower energy pulses, minimizing the unwanted thermal effects from megahertz-rate fs pulses. The anisotropic nanostructures are exploited for 5D data storage with a rate of 106voxels/s, corresponding to a demonstrated fast information recording of ∼225kB/s and a potentially high-density data storage of ∼500TB/disk.
In Optica, The Optical Society’s (OSA) journal for high impact research, Qiu and colleagues describe a new approach for digitizing color. It can be applied to cameras and displays — including ones used for computers, televisions and mobile devices — and used to fine-tune the color of LED lighting.
“Our new approach can improve today’s commercially available displays or enhance the sense of reality for new technologies such as near-eye-displays for virtual reality and augmented reality glasses,” said Jiyong Wang, a member of the PAINT research team. “It can also be used to produce LED lighting for hospitals, tunnels, submarines and airplanes that precisely mimics natural sunlight. This can help regulate circadian rhythm in people who are lacking sun exposure, for example.”
