Blog – Page 52

Researchers have suspected for some time that the link between our gut and brain plays a role in the onset of Parkinson’s disease.

A recent study identified gut microbes likely to be involved and linked them with decreased riboflavin (vitamin B2) and biotin (vitamin B7), suggesting an unexpectedly simple treatment that may help: B vitamins.

“Supplementation therapy targeting riboflavin and biotin holds promise as a potential therapeutic avenue for alleviating PD symptoms and slowing disease progression,” Nagoya University medical researcher Hiroshi Nishiwaki said when the study was published in May 2024.

Ever since Biogen and Eisai’s Aduhelm (aducanemab) was approved in 2021 as the first antibody to treat Alzheimer’s disease by clearing amyloid plaques from the brain, the modality has been dogged by a serious side effect: brain bleeding called amyloid-related imaging abnormalities, or ARIA.

Now, researchers from Denali Therapeutics have debuted an antibody that can cross the blood-brain barrier and attack amyloid, but without triggering this potentially life-threatening complication.