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A new method that increases the signal from CRISPR-based diagnostic tests, removing the need for amplification of DNA or RNA in a sample, could be used to quickly diagnose heart attacks and differentiate between cancer types.

A discovery made by researchers at the University of California, Irvine on how a certain protein is activated in tumor cells may lead to more effective treatments for some of the most deadly types of cancer. The finding, which was led by scientists at the School of Biological Sciences, may potentially result in treatment options for the especially dangerous melanoma and pancreatic adenocarcinoma, as well as the most common type of childhood brain cancer and adult skin cancer. The study was published in the journal Life Science Alliance.

The GLI1 protein, which is essential for cell development but has also been linked to a number of cancers, was the subject of the finding. The Hedgehog signaling pathway, also known as HH, usually activates GLI1. However, scientists have known for almost a decade that crosstalk, or interaction, between HH and the mitogen-activated protein kinase pathway, has a role in cancer.

“In some cases, proteins in one pathway can turn on proteins in another,” said lead author A. Jane Bardwell, a project scientist in UCI’s Department of Developmental and Cell Biology. “It’s a complex system. We wanted to understand the molecular mechanism that leads to GLI1 being activated by proteins in the MAPK pathway.”

Researchers from the University of Pennsylvania demonstrated in a proof-of-concept study that a hands-free device could successfully automate the treatment and removal of dental plaque and bacteria that cause tooth decay.

In the future, a shape-shifting robotic microswarm may serve as a toothbrush, rinse, and dental floss all in one. The technology, created by a multidisciplinary team at the University of Pennsylvania, has the potential to provide a brand-new, automated method for carrying out the repetitive but important daily duties of brushing and flossing. For people who lack the manual dexterity to efficiently clean their teeth alone, this system could be extremely helpful.

These microrobots are composed of iron oxide nanoparticles with catalytic and magnetic properties. Researchers were able to control their movement and configuration using a magnetic field to either produce bristle-like structures that remove dental plaque from the wide surfaces of teeth or elongated threads that can slide between teeth like a piece of floss. In both situations, the nanoparticles are driven by a catalytic reaction to release antimicrobials that eliminate harmful oral bacteria on site.

Chemical reactions often produce messy mixtures of different products. Hence, chemists spend a lot of time coaxing their reactions to be more selective to make particular target molecules. Now, an international team of researchers has achieved that kind of selectivity by delivering voltage pulses to a single molecule through an incredibly sharp tip.

“Controlling the pathway of a chemical reaction, depending on the voltage pulses used, is unprecedented and very alluring to chemists,” says KAUST’s Shadi Fatayer.

The team used an instrument that combines scanning tunneling microscopy (STM) and atomic force microscopy (AFM). Both techniques can map out the positions of atoms within individual molecules using a tip that may be just a few atoms wide. But the voltage can also be used to break bonds within a molecule, potentially allowing new bonds to form.

Researchers looking to synthesize a brighter and more stable nanoparticle for optical applications found that their creation instead exhibited a more surprising property: bursts of superfluorescence that occurred at both room temperature and regular intervals. The work could lead to the development of faster microchips, neurosensors, or materials for use in quantum computing applications, as well as a number of biological studies.

Superfluorescence occurs when atoms within a material synchronize and simultaneously emit a short but intense burst of light. The property is valuable for quantum optical applications, but extremely difficult to achieve at room temperatures and for intervals long enough to be useful.

The material in question—lanthanide-doped upconversion nanoparticle, or UCNP—was synthesized by the research team in an effort to create a “brighter” optical material. They produced hexagonal ceramic crystals ranging from 50 nanometers (nm) to 500 nm in size and began testing their lasing properties, which resulted in several impressive breakthroughs.

Single-wall carbon nanotubes are made of carbon with diameters less than 100 nanometers. Here, the authors engineer an analogue tube with a diameter 1,000,000 times larger with the aim to explore topological properties including unusual acoustic edge states.

A study of Li-metal batteries by the research team led by Dr. Byung Gon Kim at Next-Generation Battery Research Center of Korea Electrotechnology Research Institute (KERI) was published as a cover paper in the international journal ACS Nano.

While the current Li-ion batteries generate energy by taking Li-ions in and out of the graphite anode based on the intercalation mechanism, the Li-metal battery does not rely on this bulky and heavy graphite but uses metallic Li itself as the anode. As the Li-metal shows 10 times higher theoretical capacity (3,860 mAh/g) than graphite (372 mAh/g), it has steadily gained much attention from areas that need high-capacity batteries, such as electric vehicles and energy storage systems.

Despite this advantage, Li can grow in the shape of a tree branch, called a Li dendrite, if it is not uniformly and effectively stored when cycling process, leading to large volume expansion of the electrode, which in turn may shorten the battery’s cycle life and cause safety issue such as fire and explosion triggered by internal short-circuits.

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As the architecture, engineering and construction (AEC) industry is undergoing a staggering growth in the creation of data, organizations need to place a strong focus on data governance best practices.

That is one of the findings of a new study of the AEC sector that reveals it has experienced a 31.2% compound growth rate in data storage since 2017. The amount of new data being captured or created is staggering, but getting full value from it depends on how the data is managed, stored, accessed and protected.

A team of researchers at the University of Vienna, the Austrian Academy of Sciences and the University of Duisburg-Essen have found a new mechanism that fundamentally alters the interaction between optically levitated nanoparticles. Their experiment demonstrates previously unattainable levels of control over the coupling in arrays of particles, thereby creating a new platform to study complex physical phenomena. The results are published in this week’s issue of Science.

Imagine dust particles randomly floating around in the room. When a laser is switched on, the particles will experience forces of light and once a particle comes too close it will be trapped in the focus of the beam. This is the basis of Arthur Ashkin’s pioneering Nobel prize work of optical tweezers. When two or more particles are in the vicinity, light can be reflected back and forth between them to form standing waves of light, in which the particles self-align like a crystal of particles bound by light. This phenomenon, also called optical binding, has been known and studied for more than 30 years.

It came as quite a surprise to the researchers in Vienna when they saw a completely different behavior than was expected when studying forces between two glass nanoparticles. Not only could they change the strength and the sign of the binding force, but they could even see one particle, say the left, acting on the other, the right, without the right acting back on the left. What seems like a violation of Newton’s third law (everything that is being acted upon acts back with same strength but opposite sign) is so-called non-reciprocal behavior and occurs in situations in which a system can lose energy to its environment, in this case the laser. Something was obviously missing from our current theory of optical binding.