Lifeboat Foundation

Summary: A genetic form of frontotemporal dementia is associated with abnormal lipid accumulation in the brain fueled by disrupted cell metabolism. The findings could pave the way for new targeted therapies for FTD.

Source: Harvard.

Dementia encompasses a range of neurodegenerative conditions that lead to memory loss and cognitive deficiencies and affect some 55 million people worldwide. Yet despite its prevalence, there are few effective treatments, in part because scientists still don’t understand how exactly dementia arises on a cellular and molecular level.

‘Like conductive Play-Doh’: breakthrough could point way to a new class of materials for electronic devices.

University of Chicago.

Founded in 1,890, the University of Chicago (UChicago, U of C, or Chicago) is a private research university in Chicago, Illinois. Located on a 217-acre campus in Chicago’s Hyde Park neighborhood, near Lake Michigan, the school holds top-ten positions in various national and international rankings. UChicago is also well known for its professional schools: Pritzker School of Medicine, Booth School of Business, Law School, School of Social Service Administration, Harris School of Public Policy Studies, Divinity School and the Graham School of Continuing Liberal and Professional Studies, and Pritzker School of Molecular Engineering.

We all found our coping strategies for riding out the pandemic in 2020. Biomedical engineer Gough Lui likes to tinker with tech—particularly vintage tech—and decided he’d try to recreate what it was like to connect to the Internet via dialup back in the late 1990s. He recorded the entire process in agonizing real time, dotted with occasional commentary.

Those of a certain age (ahem) well remember what it used to be like: even just booting up the computer required patience, particularly in the earlier part of the decade, when one could shower and make coffee in the time it took to boot up one’s computer from a floppy disk. One needed a dedicated phone line for the Internet connection, because otherwise an incoming call could disrupt the connection, forcing one to repeat the whole dialup process.

What is exotic matter, and could we use it to make wormholes? – Julia, aged 14, London.

A team of astrophysicists has revealed an unusual discovery they say appears to challenge our current understanding of gravity based on Newton’s law of universal gravitation, according to a newly published paper.

The controversial claim, published in the Monthly Notices of the Royal Astronomical Society, appears to be consistent with alternative interpretations about one of physics’ most mysterious fundamental interactions.

In their new study, an international team of astrophysicists says that they came upon the discovery while investigating open star clusters. These formations are created as a gas cloud emerges following the birth of thousands of stars within a relatively short time, the remnants of which are ejected as these clusters of stars ignite and begin to expand, which can result in the formation of anywhere from several dozen, to several thousands of new stars.

If conditions on a distant planet allowed life to flourish, would it look anything like life here on Earth? It’s a question that’s seen a Darwinian rise of contradictory theories over the years.

Now, in an interview with the BBC’s Science Focus magazine, Simon Conway Morris, an evolutionary palaeobiologist at the University of Cambridge, says “with reasonable confidence” that human-like evolution has occurred in other parts of the universe.

Matthew Cobb is a zoologist and author whose background is in insect genetics and the history of science. Over the past decade or so, as CRISPR was discovered and applied to genetic remodeling, he started to get concerned—afraid, actually—about three potential applications of the technology. He’s in good company: Jennifer Doudna, who won the Nobel Prize in Chemistry in 2020 for discovering and harnessing CRISPR, is afraid of the same things. So he decided to delve into these topics, and As Gods: A Moral History of the Genetic Age is the result.

Summing up fears

The first of his worries is the notion of introducing heritable mutations into the human genome. He Jianqui did this to three human female embryos in China in 2018, so the three girls with the engineered mutations that they will pass on to their kids (if they’re allowed to have any) are about four now. Their identities are classified for their protection, but presumably their health is being monitored, and the poor girls have probably already been poked and prodded incessantly by every type of medical specialist there is.

The James Webb Space Telescope has released a spooky new photo of the iconic Pillars of Creation.

In a Thursday release, NASA wrote that the eerie image was taken by the $10 billion-dollar observatory’s Mid-Infrared Instrument, also known as MIRI.

The pillars of gas and Interstellar dust enshroud the thousands of stars that exist in the region.

European Space Agency · The scary sound of Earth’s magnetic field

The resulting five-minute audio includes eerie creaks and crackling sounds, as well as deep breathing-like sounds that listeners on social media described as “petrifying” and “spine tingling freaky.”

Since the discovery was revealed on October 24, loudspeakers at Solbjerg Square in Copenhagen, Denmark, have broadcasted the recording three times a day. Plans are to continue playing it each day at 8 a.m., 1 p.m., and 7 p.m. through October 30.