Analysis shows most security risk sits in longtail open source images, with 98% of CVEs outside top projects & Critical flaws fixed in under 20 hours.
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China-Linked UAT-7290 Targets Telecoms with Linux Malware and ORB Nodes
A China-nexus threat actor known as UAT-7290 has been attributed to espionage-focused intrusions against entities in South Asia and Southeastern Europe.
The activity cluster, which has been active since at least 2022, primarily focuses on extensive technical reconnaissance of target organizations before initiating attacks, ultimately leading to the deployment of malware families such as RushDrop, DriveSwitch, and SilentRaid, according to a Cisco Talos report published today.
“In addition to conducting espionage-focused attacks where UAT-7290 burrows deep inside a victim enterprise’s network infrastructure, their tactics, techniques, and procedures (TTPs) and tooling suggest that this actor also establishes Operational Relay Box (ORBs) nodes,” researchers Asheer Malhotra, Vitor Ventura, and Brandon White said.
Gmail’s new AI Inbox uses Gemini, but Google says it won’t train AI on user emails
Google says it’s rolling out a new feature called ‘AI Inbox,’ which summarizes all your emails, but the company promises it won’t train its models on your emails.
On Thursday, Google announced a new era of Gmail where Gemini will be taking over your default inbox screen.
Google argues that email has changed since 2004, as users are now bombarded with hundreds of emails every week, and volume keeps rising.
Behind nature’s blueprints: Physicists create ‘theoretical rulebook’ of self-assembly
Inspired by biological systems, materials scientists have long sought to harness self-assembly to build nanomaterials. The challenge: the process seemed random and notoriously difficult to predict.
Now, researchers from the Institute of Science and Technology Austria (ISTA) and Brandeis University have uncovered geometric rules that act as a master control panel for self-assembling particles.
The results, which could find applications ranging from protein design to synthetic nanomachines, were published in Nature Physics.
Gravity May Be Key Evidence That Our Universe Is a Simulation, Groundbreaking New Research Suggests
One of nature’s most familiar forces might be doing something far stranger than we ever imagined.
Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice
Cáliz-Molina et al. demonstrate that hydrogen sulfide generators found in garlic extend lifespan and enhance metabolic, neurocognitive, and locomotor function in male mice. These molecules induce hepatic lipid-droplet remodeling and modulate aging-associated pathways at transcriptomic, proteomic, and persulfidomic levels. In humans, increased cysteine persulfidation correlates with relevant aspects of health.
Lenacapavir treatment–emergent HIV-1 capsid resistance mutations are frequently associated with replication defects
Can HIV become resistant to lenacapavir?
An analysis of clinical isolates identifies mutations that shift the capsid protein’s lenacapavir binding pocket and endow resistance, but shows these mutations often come at a high fitness cost.
Read more in.
Treatment-emergent capsid mutations elicited by lenacapavir monotherapy showed variable drug resistance and viral fitness impacts.
Targeting B cells enhances STING agonism in liver cancer
The researchers used advanced laboratory and experimental models to uncover how B-cells contribute to immunotherapy resistance in liver cancer. Using liver cancer mouse models, they tested treatments that either blocked B-cells or targeted immune pathways.
They found that when tumors stopped responding to immunotherapy, B-cells moved into the tumor and formed clusters that looked like special immune structures called tertiary lymphoid tissues.
“Combining B-cell depletion with immunotherapy (anti-PD-1 ICB or the STING agonist BMS-986301) significantly improved survival and reduced metastasis,” said the author. “These exciting findings suggest that targeting B-cells or their signaling pathways could overcome acquired resistance and enhance the effectiveness of cancer immunotherapy, including in cases where the disease has spread.”
Scientists have identified a promising strategy to improve liver cancer immunotherapy: targeting B-cells. While immunotherapy has transformed cancer treatment by activating T-cells—a type of immune cell that fights cancerous cells—many patients still fail to respond. New research shows that B-cells—another type of immune cells that fight infections—may play a surprising role in limiting immunotherapy’s effectiveness.
The study was recently published in Nature Communications. The study’s principal investigator said that most current research efforts are focusing on activating T-cells against cancers. This study showed tumor-associated B-cells can create an environment that suppresses T-cell activity, allowing cancer cells to escape immune attacks.
“We observed a significant rise in B-cell activity in the tumor, suggesting they may play an important role in how cancer escapes treatment,” said the author. “By blocking these immunosuppressive B-cells, we may be able to remove this barrier and enhance the power of immunotherapy.”