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Virus-enveloping macromolecular shells or tilings can prevent viruses from entering cells. Here, we describe the design and assembly of a cone-shaped DNA origami higher-order assembly that can engulf and tile the surface of pleomorphic virus samples larger than 100 nm. We determine the structures of subunits and of complete cone assemblies using cryoelectron microscopy (cryo-EM) and establish stabilization treatments to enable usage in in vivo conditions. We use the cones exemplarily to engulf influenza A virus particles and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), chikungunya, and Zika virus-like particles. Depending on the relative dimensions of cone to virus particles, multiple virus particles may be trapped per single cone, and multiple cones can also tile and adapt to the surface of aspherical virus particles. The cone assemblies form with high yields, require little purification, and are amenable for mass production, which is a key requirement for future real-world uses including as a potential antiviral agent.

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Far below our feet, a giant may have started moving against us.

Earth’s , a hot iron ball the size of Pluto, has stopped spinning in the same direction as the rest of the planet and might even be rotating the other way, research suggested on Monday.

Roughly 5,000 kilometers (3,100 miles) below the surface we live on, this “planet within the planet” can spin independently because it floats in the .

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A threat actor tracked as DEV-0569 uses Google Ads in widespread, ongoing advertising campaigns to distribute malware, steal victims’ passwords, and ultimately breach networks for ransomware attacks.

Over the past couple of weeks, cybersecurity researchers MalwareHunterTeam, Germán Fernández, and Will Dormann have illustrated how Google search results have become a hotbed of malicious advertisements pushing malware.

These ads pretend to be websites for popular software programs, like LightShot, Rufus, 7-Zip, FileZilla, LibreOffice, AnyDesk, Awesome Miner, TradingView, WinRAR, and VLC.

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The WordPress online course plugin ‘LearnPress’ was vulnerable to multiple critical-severity flaws, including pre-auth SQL injection and local file inclusion.

LearnPress is a learning management system (LMS) plugin that allows WordPress websites to easily create and sell online courses, lessons, and quizzes, providing visitors with a friendly interface while requiring no coding knowledge from the website developer.

The vulnerabilities in the plugin, used in over 100,000 active sites, were discovered by PatchStack between November 30 and December 2, 2022, and reported to the software vendor.

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The concept of emergence is controversial to some — for example Eliezer Yudkowski, who favors reductionism, wrote a critique at Less Wrong (see link below). Do reductionists often dismiss emergence?

Ben formalized emergence in his book ‘The Evolving Mind’ as patterns that appear when you put two or more things together that are not there in any of the individual parts.
Book — ‘The Evolving Mind’: http://www.goertzel.org/books/mind/contents.html http://www.amazon.com/Evolving-Futures-General-Evolution-Stu…atfound-20

Eliezer’s post on ‘The Futility of Emergence’ at Less Wrong: http://lesswrong.com/lw/iv/the_futility_of_emergence/

Talking points: EMERGENCE & REDUCTION, CONFUSION REGARDING EMERGENCE, LARGE SCALE NEUROSCIENCE PROJECTS, EMERGENCE AS A WAY OF EXPLAINING AWAY COMPLEXITY, IS CONSCIOUSNESS AN EMERGENT EFFECT? EMERGENCE & ARTIFICIAL INTELLIGENCE

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It has been believed that Hall thrusters, an efficient kind of electric propulsion widely used in orbit, must be large to produce a lot of thrust. Now, a new study from the University of Michigan suggests that smaller Hall thrusters can generate much more thrust—potentially making them candidates for interplanetary missions.

“People had previously thought that you could only push a certain amount of current through a thruster area, which in turn translates directly into how much force or thrust you can generate per unit area,” said Benjamin Jorns, U-M associate professor of who led the new Hall thruster study to be presented at the AIAA SciTech Forum in National Harbor, Maryland, today.

His team challenged this limit by running a 9 kilowatt Hall thruster up to 45 kilowatts, maintaining roughly 80% of its nominal efficiency. This increased the amount of force generated per unit area by almost a factor of 10.

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Researchers have developed a robot that brings speed, agility and reproducibility to laboratory-scale coin cell batteries.

Until now, laboratories studying battery technology have had to choose between the freedom to iterate and optimise battery chemistry by manually assembling each individual cell, and the reproducibility and speed of large-scale production. AutoBass (Automated battery assembly system), the first laboratory-scale coin cell assembly robot of its kind, is designed to bridge this gap.

Developed by a team from Helmholtz Institute Ulm and Karlsruhe Institute of Technology in Germany, AutoBass promises to improve characterisation of coin cell batteries and promote reproducibility by photographing each individual cell at key points in the assembly process. It produces batches of 64 cells a day.

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This is a comparison scale for all living things in the Universe.

The Kardashev scale is a technique for determining a civilization’s technical degree of progress. In 1964, Soviet astronomer Nikolai Kardashev suggested it. Based on the entire quantity of energy that the human species can collect and use, this scale system helps us comprehend how far the human species can progress.

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In a recent study that was sent to MNRAS, a group of researchers worked together to use the first batch of data from the James Webb Space Telescope (JWST) to find a candidate galaxy, CEERS-93316, that formed about 250 million years after the Big Bang and set a new record for redshift with a value of z = 16.7. This discovery is very exciting because it shows how good JWST is, even though it has only just started sending back its first set of data. The Cosmic Evolution Early Release Science Survey, or CEERS, was made so that it could be used with JWST to take pictures.

“The past few weeks have been surreal, watching all the records that stood for a long time with Hubble be broken by JWST,” says Dr. Rebecca Bowler, who is an Ernest Rutherford Fellow at the University of Manchester, and a co-author on the study. “Finding a z = 16.7 galaxy candidate is an amazing feeling – it wasn’t something we were expecting from the early data.”

This new study talks about a dozen previous studies that measured objects up to redshifts z 10 using a mix of ground-based observations and the Hubble Space Telescope and Spitzer Space Telescope.

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