Be Brave. Be Kind. Be BRILLIANT.
For centuries, humanity has wondered what it would mean to wake up the machine. Now, leading researchers believe it may be happening.
AM I? follows AI consciousness researcher Cameron Berg as he investigates one of the deepest scientific mysteries of our time: whether we have accidentally built a new kind of mind. Featuring leading philosophers, AI pioneers, and the researchers at the frontier of consciousness science, AM I? asks what it means when we no longer know the nature of what we’ve created.
This film is fully independent and self-funded. Ads are off. If you want to learn more about the project and support our work, please visit: am-i.film.
“Fascinating and scary.” — Sam Harris (Neuroscientist, Philosopher; Host of Making Sense Podcast)
“Terrific.” — Michael Pollan (Bestselling Author, How to Change Your Mind)
The first safety test is done, and it is good.
Life Biosciences has released the first human Phase 1 clinical trial safety data for ER-100, an AAV2 gene therapy testing partial epigenetic reprogramming in patients with open-angle glaucoma. In this video, we analyze the 56-day safety profile, early visual field perimetry results, and how inducible OSK transcription factors aim to restore optic nerve function.
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Image generators tune their noise by trial and error, because pictures have no clock. Turbulent plasmas do. By syncing an AI’s noise to the known rate at which particles spread, researchers built a surrogate that matches lab measurements—no tuning required.
The problem: Scientists often need fast, cheaper stand-ins (“surrogates”) for complex computer simulations of physical systems—in this case, systems where particles spread out over time, like heat diffusing or particles scattered by turbulence. A good stand-in should capture not just the average behavior but the full range of possible outcomes, including how spread out and lopsided the distribution becomes.
The tool they used: Generative diffusion models—the same kind of AI behind image generators—work by gradually adding noise to data and learning to reverse that process. But in image generation, there’s no physical meaning to “how much noise at each step”; the schedule is just a tuning choice. In particle transport, though, physicists already know how fast the spread (variance) grows over time, even without knowing the full distribution.
The key idea: The researchers set the noise schedule to match the known rate of spreading. This turns the model’s internal “time” into a real physical clock. The model then learns only the finer details—how the shape of the distribution evolves—without needing actual simulation data at intermediate times.
The result: Tested on particles moving through turbulent plasmas (going from fast, straight-line motion to slow diffusion), the surrogate reproduced the simulated particle distributions, matched the spread measured in the lab, and captured how the distribution’s shape (its “kurtosis,” or tailedness) evolved—all without any hand-tuning. This makes it useful both for fast emulation and for statistical inference from data.
#ArtificialIntelligence #PlasmaPhysics #turbulence #DiffusionModels
In February 2022, nine months before ChatGPT launched, a story scientist sat down with me and argued that computers cannot be creative.
Not “aren’t yet.” Cannot.
Angus Fletcher started out as a neuroscientist at the University of Michigan. Then he left the lab to do a PhD in Shakespeare at Yale. Then DARPA, Hollywood, and US Special Operations came knocking. Ask yourself what elite soldiers want from a Shakespeare scholar, because the answer is not what you’d guess.
His case rests on a claim most of the #AI industry has bet billions against: the brain is not a computer, and the difference is physical, not a matter of more data or bigger models. For Angus, story is the operating system of the human brain, and #literature is the engine of science rather than its decorative cousin.
We went for two hours. We argued about my own definition of story, about why a multiplicity might serve us better than a #singularity, and about Humanism versus AI-ism.
Four years and one generative AI gold rush later, I went back and rewatched it. You can decide for yourself whether the past four years proved him wrong or proved his point.
Why colonize one universe when reality may offer infinitely many? We explore alternate Earths, multiversal travel, dangerous new worlds, and the rise of Omega-class civilizations spanning entire realities.
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/ discord Credits: Colonizing the Multiverse: Beyond the Kardashev Scale Into Infinite Universes Written, Produced & Narrated by: Isaac Arthur Editor: Thomas Owens Music Courtesy of Stellardrone & Chris Zabriskie Select imagery/video supplied by Getty Images Chapters 0:00 Intro 2:22 The Geography of Reality 5:30 Why Colonize the Multiverse? 9:30 The First Beachhead 13:52 The Navigation Problem 17:35 Settlement Strategies 28:19 Rifftrax 29:11 Beyond the Kardashev Scale – Omega-Class Civilizations.
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Credits:
Colonizing the Multiverse: Beyond the Kardashev Scale Into Infinite Universes.
Written, Produced \& Narrated by: Isaac Arthur.
Editor: Thomas Owens.
Music Courtesy of Stellardrone \& Chris Zabriskie.
Select imagery/video supplied by Getty Images.
Chapters.
0:00 Intro.
2:22 The Geography of Reality.
5:30 Why Colonize the Multiverse?
9:30 The First Beachhead.
13:52 The Navigation Problem.
17:35 Settlement Strategies.
28:19 Rifftrax.
29:11 Beyond the Kardashev Scale – Omega-Class Civilizations.
A Stanford-designed molecule turns a major lymphoma-promoting protein against cancer cells, activating their own self-destruct machinery instead of simply blocking tumor growth. In mice, the treatment completely eliminated aggressive human lymphoma tumors within 11 days, although much more testing is needed before it could reach patients.
Which genes need to be controlled to guide a stem cell toward a desired cell type, or to modulate an immune cell’s inflammatory response? A research team has developed a general-purpose computational framework that identifies the key targets needed to steer a cell toward a desired state with a single temporary intervention, without permanently altering its genes.
NUDGE, a foundational technology that redirects cell fate in a desired direction through a minimal, temporary intervention by harnessing the gene regulatory dynamics already present within cells.
Technologies that redirect cell fate have drawn attention as key tools for treating intractable diseases and advancing regenerative medicine, since they can be used to differentiate stem cells into cells with specific functions or to return diseased or aged cells to a near-normal state. Differentiation, for example, refers to the process by which a stem cell becomes a specific cell type with a distinct function, such as a cardiomyocyte or a neuron.