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PAI-1 Impacts Telomere Length, Cell Senescence, And Longevity
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Hundreds feared stuck in hydropower tunnels as flood deaths surpass 950 in Nepal and China
KATHMANDU, Nepal (AP) — Rescuers raced Monday to free hundreds of workers believed to be trapped in tunnels at hydropower sites that were buried in mud by catastrophic flooding on the Nepal-China border, as the death toll climbed and increasingly desperate families searched for missing loved ones.
The combined deaths in Nepal and China surpassed 950, with more than 4,400 people missing. A private-sector association representing power companies said at least 900 workers were unaccounted for at 12 hydropower projects damaged by the flash floods in Nepal’s Rasuwa and Nuwakot districts.
About 500 of those workers were believed to be trapped in tunnels. At least one expert said that some workers could have access to oxygen, but others warned that the chances of finding survivors were diminishing. As the rescue efforts intensified, four bodies were recovered from three mud-filled tunnels, Nepal’s army said.
New guidelines recommend all patients with heart disease are tested for kidney disease
The first-ever European Society of Cardiology Guidelines on the management of cardiovascular disease and chronic kidney disease have been developed in collaboration with the European Renal Association. The new guidelines were published online in the European Heart Journal and presented at ESC Congress 2026 on Aug. 29.
Chronic kidney disease (CKD) is defined as the presence of abnormalities of kidney structure or function for at least three months, with implications for health. It is estimated that around 100 million people in Europe have CKD, all of whom are at increased risk of a wide range of cardiovascular diseases (CVD) as a result of their kidney disease.
“The disability and lifetime lost to each disease are profound, but CKD can accelerate CVD and vice versa, resulting in cardiovascular events and the need for dialysis much earlier in life,” said Task Force Chair Associate Professor Kevin Damman from University Medical Center Groningen, Netherlands.
Scientists discover diamonds can generate electricity
Diamond was thought to be incapable of producing electricity through mechanical deformation, but ultrathin flexible diamond membranes have now shown a strong and repeatable piezoelectric effect. The unexpected discovery could open the door to diamond-powered sensors, tiny energy systems, and self-powered medical implants.
Stem Cell Therapy: Past, Present, and Future Aspects
Background/Objectives: Stem cells with the ability to differentiate into other cell types and self-renewal afford a powerful apparatus for the healthcare system to replace and rejuvenate damaged tissues and organs in the treatment of various diseases. For the last few decades, stem cell therapy (SCT) has evolved from being an experimental approach to a recognized clinical treatment. SCT and regenerative medicine have garnered tremendous attention and become prominent tools, especially in treating chronic and acute disease and addressing organ failures, and in their repair and replacement, which are directly associated with human health, life, and longevity. Methods: In this review, after providing a brief history and need for the SCT, the employed delivery techniques utilizing various biomaterials, as well as recent developments in nanotechnological methods, are presented.
Researchers Have Discovered a New Way To Reduce Chronic Nerve Pain
A cancer-linked protein called BRAF may help drive chronic nerve pain, and existing cancer drugs targeting it reduced pain sensitivity in preclinical models.
Chronic nerve pain can persist long after an injury and often responds poorly to standard pain medications. Researchers at The University of Texas MD Anderson Cancer Center now report evidence that BRAF, a protein best known for its role in cancer, may also help initiate, intensify, and sustain pain signaling after nerve damage.
In preclinical models, drugs that inhibit BRAF signaling reduced pain sensitivity, pointing to a possible new use for treatments already developed for cancer.