Studies in mice suggest it is more sophisticated than once thought
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New atlas traces how key human brain cells develop before and after birth
Scientists have long known that many developing brain cells originate in one region and migrate to another as they mature. But tracing the molecular changes that occur along that journey has been difficult, in part because some of the temporary prenatal brain structures that give rise to these cells largely disappear around birth.
One important destination for these developing cells is the basal ganglia, a group of interconnected structures deep in the brain that help control movement, habits, reward and behavior. This region is also implicated in conditions including Parkinson’s disease, Huntington’s disease, addiction, obsessive-compulsive disorder and schizophrenia.
Now, in a study published in Cell, a research team co-led by UCLA has mapped this developmental process in unprecedented molecular detail, tracing how cells in and around the basal ganglia change from midpregnancy through infancy.
This Longevity Molecule Extends Primate Lifespan by 15% | Dr. Adam Salmon
Dr. Adam Salmon, Associate Director of the Barshop Institute at UT Health San Antonio, reveals historic findings from the first long-term rapamycin trial in non-human primates. Discover how daily mTOR inhibition extends marmoset median lifespan by 10% to 15%, preserves kidney function, and why primate glucose metabolism responds differently to rapamycin than rodents.
For deeper breakdowns of emerging longevity trials and key takeaways from our expert interviews, subscribe to the Modern Healthspan Briefing: https://modernhealthspan.substack.com… Support Cellular Energy & Mitochondrial Health: Optimize your metabolic pathways with Renue By Science Liposomal NAD+, GlyNAC, and longevity formulas: 👉 (10% off: MHS) https://tinyurl.com/bdew4bfs — NMN Powder • Lipo NR • Spermidine 🧬 SUPPORT THE CHANNEL & LONGEVITY PARTNERS If you would like to support our channel please consider joining our Patreon: / modernhealthspan Seeking Health (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ — Zinc Picolinate • Optimal D3+K2 Stemregen (15% off: MODERN) US only https://tinyurl.com/45z968yr AX3 Life (20% off: MODERN20) https://ax3.life/MODERN20 — Astaxanthin n1o1 (10% off: Modern) https://tidd.ly/3IczGRW — Nitric Oxide Lozenges Qualia (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd • Senolytic https://bit.ly/4jlaibe Wellness Extract (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE — Geranylgeraniol • Vit E 00:00 — Why Marmosets Are the Ideal Primate Model for Aging 05:35 — Landmark Marmoset Trial: Lifespan Extended 10–15% 08:45 — Healthspan Protection: Kidney Function & Oral Health 11:17 — Dosing Strategy: Daily vs. Intermittent Protocols 13:09 — The Glucose Paradox: Blood Sugar in Primates vs. Mice 16:02 — mTORC1 vs. mTORC2: Why Mouse Liver Differs from Humans 18:40 — The Case for Pulsed Dosing & Autophagy Cycling 20:43 — Unexpected Side Effects: Marmoset Joint & Bone Data 22:46 — Cross-Species Hit Rate: Translating Mice to Humans 26:40 — Biomarkers, Metabolic Resilience & Primate Lifespan 29:07 — Primate Research Infrastructure & Nathan Shock Center 32:03 — Dismantling the Free Radical Theory of Aging 35:52 — Immune Resilience & Barshop Institute Next Steps 39:45 — Reversing Side Effects & Next-Gen mTORC1 Inhibitors 43:38 — Can AI Replace Non-Human Primate Aging Models? Can rapamycin safely slow biological aging and extend lifespan in primates? While rapamycin consistently extends mouse lifespan in the NIA’s Interventions Testing Program (ITP), key questions remained regarding primate biology and metabolic safety. Dr. Adam Salmon discusses his landmark trial in common marmosets, demonstrating a 10% to 15% increase in median survival, mirroring early mouse longevity trials. Dr. Salmon breaks down the healthspan benefits observed in these primates, including preserved kidney function, delayed oral disease, and joint protection. He unpacks metabolic differences between rodents and primates, detailing how human liver physiology differs in glucose regulation, the mechanism behind mTORC1 versus mTORC2 inhibition, and why transient metabolic side effects reverse rapidly within one week of treatment cessation. Additionally, Dr. Salmon shares insights on the Free Radical Theory of Aging and mitochondrial resilience. If you would like to support our channel please consider joining our Patreon:
/ modernhealthspan 🔬 Scientific Citations & References Mentioned: 1. Salmon, A.B. et al. Long-term treatment with the mTOR inhibitor rapamycin extends lifespan and improves healthspan in common marmosets. Landmark Primate Trial / Barshop Institute. 2. Lamming, D.W., Salmon, A.B. et al. (2012). Depletion of mTOR and mLST8 uncouples longevity from rapamycin-induced changes in glucose homeostasis. Science, 335(6076): 1638–1643. PMID: 22,461,615 3. Marolf, B.A., Salmon, A.B. et al. (2024). Impact of long-term rapamycin treatment on age-related osteoarthritis in common marmoset. bioRxiv, DOI: 10.1101/2024.05.14.594256 4. Bene, M. & Salmon, A.B. (2023). Lifespan-extending compound interventions across laboratory animal model species. GeroScience, 45: 2153–2171. PMID: 36,780,031 5. Horvath, S., Salmon, A.B. et al. (2021). DNA methylation age analysis of rapamycin in common marmosets. GeroScience, 43: 2419–2428. PMID: 34,626,308 🌐 Connect with Dr. Adam Salmon: • Barshop Institute: https://barshop.uthscsa.edu • Faculty Profile: https://uthscsa.edu/medicine/faculty/.… ⚠️ Medical Disclaimer: Modern Healthspan content is for educational and informational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult a qualified physician or healthcare provider before making changes to your health regimen, diet, or lifestyle. #Rapamycin #Longevity #Healthspan.
⚡ Support Cellular Energy & Mitochondrial Health:
Optimize your metabolic pathways with Renue By Science Liposomal NAD+, GlyNAC, and longevity formulas:
👉 (10% off: MHS) https://tinyurl.com/bdew4bfs — NMN Powder • Lipo NR • Spermidine.
🧬 SUPPORT THE CHANNEL & LONGEVITY PARTNERS
If you would like to support our channel please consider joining our Patreon: / modernhealthspan.
Seeking Health (10% off: Richard10) https://crrnt.app/SEEK/-dm0MyrQ — Zinc Picolinate • Optimal D3+K2
Stemregen (15% off: MODERN) US only https://tinyurl.com/45z968yr.
AX3 Life (20% off: MODERN20) https://ax3.life/MODERN20 — Astaxanthin.
n1o1 (10% off: Modern) https://tidd.ly/3IczGRW — Nitric Oxide Lozenges.
Qualia (15% off: MODERN) Creatine+ https://tinyurl.com/mr3z35jd • Senolytic https://bit.ly/4jlaibe.
Wellness Extract (10% off: MODERNWE) http://wellnessextract.com/RICHARDWE — Geranylgeraniol • Vit E
00:00 — Why Marmosets Are the Ideal Primate Model for Aging.
Hand gestures and vibrating belt enable drone control without visual feedback in early tests
Operating a drone manually requires pilots to watch a screen while coordinating controls. This divides attention between the aircraft and its surroundings. Researchers are exploring ways to make drone operation more intuitive and less dependent on continuous visual monitoring. A wearable interface developed at Jeonbuk National University combines hand gestures for sending commands with abdominal vibrations that indicate the drone’s position relative to the user.
The research team was led by professor Kee-Ho Yu of the Department of Aerospace Engineering at Jeonbuk National University, Republic of Korea, along with researcher Myeong-Ho Shin and Dr. Giancarlo Eder Guerra Padilla from the same institute. The team paired a sensor worn on the back of the hand with a belt containing 36 vibration motors. A computer interprets 12 gestures as drone commands. Drone telemetry is translated into vibration patterns indicating direction, relative height and distance. The system was assessed through gesture-recognition tests, simulated flying, an indoor tactile-perception study and two real-drone tasks.
This paper was published in the journal IEEE Robotics and Automation Letters.
2 scandals, 1 destination—Why Nvidia can’t shake China smuggling allegations
ALICE HUANG, JENSEN HUANG, NVIDIA AND SUPERMICRO: THE INVESTIGATION IS GETTING BIGGER.
What initially appeared to be a story about a woman suspected of having connections to Chinese intelligence and targeting Nvidia CEO Jensen Huang is now intersecting with a much larger investigation into the alleged smuggling of advanced AI hardware into China.
According to Bloomberg, the U.S. Department of Justice is investigating whether Alice Huang was involved in moving products manufactured by Super Micro Computer ($SMCI) to China in violation of U.S. export restrictions.
And this is where things get particularly interesting.
1. The Super Micro connection.
Super Micro manufactures high-performance servers used in AI data centers, many of which incorporate Nvidia GPUs.
Nvidia Will Continue To Be A Key Driver In The AI Revolution
After Jensen Huang’s departure, can Nvidia maintain its AI dominance? Its technology, infrastructure and national security role may help determine what comes next.
Unified framework establishes rules for classifying unconventional magnets
Researchers from the Hefei Institutes of Physical Science (HFIPS) of the Chinese Academy of Sciences (CAS) have developed a unified framework for establishing symmetry criteria and classifying unconventional magnets.
According to the researchers, the new framework provides a practical route for discovering and designing unconventional magnetic materials by replacing fragmented, case-by-case rules with a predictive and exhaustive symmetry principle.
Published in Newton on Nov. 12, the research was led by associate researcher Luo Xunjiang from the High Magnetic Field Laboratory of HFIPS, in collaboration with professor K.T. Law from Hong Kong University of Science and Technology.
US almonds, walnuts and grapes depend on draining groundwater that isn’t coming back
Half of the groundwater used to grow America’s favorite fruits, nuts, veggies, seeds and greens is drawn from aquifers faster than they can refill, according to a new study. Irrigating 75% of produce and specialty crops with groundwater between 2008 and 2020 helped spare farms from the immediate impacts of droughts, but dependence on draining aquifers could set up producers for future water supply strife.
A new study appearing in Water Resources Research provides the first county-level data on irrigation sources for 65 different specialty crops, including everything from cantaloupes to cabbage. “Up until this point, we’ve kind of been flying blind,” said Jackie Hanley, a civil engineering researcher at the University of Illinois at Urbana-Champaign and the study’s lead author.
Knowing where irrigation water goes and where it comes from—rivers, reservoirs or underground aquifers—is vital for farmers and policymakers deciding how to manage finite water supplies for farms in the face of mounting water scarcity.
Human basal ganglia atlas reveals how genes are regulated in individual cells
Salk Institute researchers have contributed to a landmark accomplishment in neuroscience: a 3D atlas of the human basal ganglia with single-cell genetic and epigenetic detail, published as a collection of 28 papers across Cell Press journals. The basal ganglia are a group of nerve cells that sit deep in the brain, where they control key functions like learning, emoting and moving. Basal ganglia dysfunction can lead to conditions like Parkinson’s disease, Huntington’s disease, Tourette syndrome and addiction.
The atlas offers a new window into the brain, through which scientists can identify and pinpoint each cell in the human basal ganglia. This comprehensive database of brain cells and functions could be used to create personalized therapeutics, identify relevant epigenetic and genetic targets for gene-editing therapies, and link genetic risks with particular cell types for more targeted, effective treatments.
The effort is part of the Brain Research Through Advancing Innovative Neurotechnologies Initiative, or the BRAIN Initiative, a massive collaboration launched in 2014 that brings together scientists to “revolutionize our understanding of the human brain.”
NVIDIA Announces CEO Transition
Jensen Huang resigns as NVIDIA’s CEO.
Nvidia CFO Colette Kress takes over as interim CEO after Jensen Huang resigns, effective immediately.
Nvidia’s official release, “NVIDIA Announces CEO Transition,” formally confirms Jensen Huang’s immediate resignation as President, Chief Executive Officer, and member of the Board of Directors after 33 years at the helm, while establishing an interim governance structure designed to reassure investors and customers ahead of upcoming quarterly results.
Core Structural Announcements.
* Immediate Resignation: Jensen Huang stepped down from all executive and board roles effective immediately, concluding his tenure leading the company he co-founded in 1993.
* Interim Leadership: Executive Vice President and Chief Financial Officer Colette Kress has been appointed Interim CEO while continuing to serve as CFO. She has been a central architect of Nvidia’s financial and operational scaling since joining in September 2013.
* Board Restructuring & Search: Longtime director and former Synopsys CEO Harvey C. Jones has been named Nvidia’s first-ever Chair of the Board. The board has initiated a formal search process—evaluating both internal executives and external candidates—to identify a permanent successor.