Lifeboat Foundation

The Laboratoire Sous-marin Provence Méditerranée (LSPM) lies 40 km off the coast of Toulon, at a depth of 2,450 m, inaccessible even to sunlight. Through this national research platform run by the CNRS in collaboration with Aix-Marseille University (AMU) and IFREMER, scientists will investigate undersea unknowns while scanning the skies for neutrinos. These elementary particles of extraterrestrial origin know few obstacles and can even traverse our planet without bumping into a single atom.

The main instrument at the LSPM is KM3NeT, a giant neutrino detector developed by a team of 250 researchers from 17 countries. In the pitch-black abyss, KM3NeT will study the trails of bluish light that neutrinos leave in the water. Capable of detecting dozens of these particles a day, it will help elucidate their quantum properties, which still defy our understanding.

The other LSPM instruments will permit the scientific community to study the life and chemistry of these depths. They will offer researchers insights into ocean acidification, deep-sea deoxygenation, marine radioactivity, and seismicity, and allow them to track cetacean populations as well as observe bioluminescent animals. This oceanographic instrumentation is integrated into the subsea observatory network of the EMSO European research infrastructure.

Scientists at Osaka University were part of a particle accelerator experiment that produced an exotic and highly unstable particle, and determined its mass. This could contribute to a better understanding of the inner workings of ultra-dense neutron stars.

The Standard Model of particle physics explains that most particles are made of combinations of just six types of basic entities called quarks. However, there are still many unsolved mysteries, one of which is Λ(1405), an exotic but fleeting Lambda resonance. It was previously believed to be a specific combination of three quarks – up, down, and strange – and gaining insight into its composition could assist in uncovering information about the extremely dense matter in neutron stars.

Now, investigators from Osaka University were part of a team that succeeded in synthesizing Λ(1405) for the first time by combining a K^– meson and a proton and determining its complex mass (mass and width). The K^– meson is a negatively charged particle containing a strange quark and an up antiquark.

We’ve known about telomeres for more than 80 years, but these tiny, protective structures at the end of the chromosomes keep revealing secrets to us, including the possibility of having surprising functions.

It turns out that these key biological cogs can produce proteins, something previously thought impossible due to their simplicity.

While it’s not clear yet what these proteins might do, the fact that they exist at all is significant.

X-ALD is the most prevalent of the approximately 50 rare diseases that affect the white matter of the brain, referred to as leukodystrophies. The genetic damage in X-ALD is due to a defect in the X chromosome. Men who are affected by X-ALD experience a progressive deterioration of their mobility, balance, and sensory abilities, leading to issues such as incontinence and sexual dysfunction.

Although X-ALD is inherited through the X chromosome, female carriers can also experience symptoms of the disease. Approximately 30% of male children and 60% of adult men develop encephalitis, which is a fatal form of the disease that leads to death within two to three years. X-ALD affects roughly one in every 20,000 births globally.

Now, for the first time, scientists from all relevant leukodystrophy centers in Europe and the US have jointly succeeded in obtaining controlled trial data for X-linked adrenoleukodystrophy. Of the 116 patients, 77 received the drug leriglitazone and 39 a placebo. The drug had already shown in preclinical studies that it can prevent neurodegeneration and offer protection against the life-threatening inflammation of the brain.

Another orbit around the sun and here we are again: back where we started but spun about — changed, perhaps deranged.

Henry Segerman, a British American mathematician and mathematical artist at Oklahoma State University, has invented just the puzzle for this disorienting annual event: Continental Drift, a 3D sliding puzzle that made its debut earlier this year. The underlying geometric concept is holonomy: When you travel a loop on a curved surface and return to the starting point, you arrive somewhat turned around, rotated, perhaps by 180 degrees.

Human being, vegetables or cosmic dust, we all dance to an invisible tune, intoned in the distance by a mysterious player.

Adding a new layer to the already complex world of metaphysics.

Experts warn that while the fungal parasite featured in HBO’s popular show “The Last of Us” may only be fictional, the threat from real-life fungal pathogens is on the rise around the world.

Last year, Sony AI and Polyphony Digital, the developers of Gran Turismo, developed a new AI agent that is able to race at a world-class level. At the time, the experiment was described in a paper in Nature, where the researchers showed that this AI was not only capable of driving very fast—something other AI have done in the past—but also learned tactics, strategy, and even racing etiquette.

At the time, GT Sophy—the name of the AI—wasn’t quite ready for prime time. For example, it often passed opponents at the earliest opportunity on a straight, allowing itself to be overtaken in the next braking zone. And unlike human players, GT Sophy would try to overtake players with impending time penalties—humans would just wait for that penalized car to slow to gain the place.