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A new Yale study finds low ejectionfraction – the amount of blood your heart pumps out with each beat – is associated with worse cardiovascular outcomes for patients with peripheral artery disease (PAD):

You can learn more about important PAD risk factors here: https://brnw.ch/21wDlIR

Peripheral arterial disease (PAD) is commonly associated with coronary artery disease (CAD), and echocardiography is frequently performed prior to lower extremity revascularization (LER). However, the incidence of various echocardiographic findings in patients with PAD and their impact on the outcomes of LER has not been well studied.

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“Cancer” is not a word we want to hear. Conversations with your doctor about cancer can induce fear, anxiety, and a plethora of other emotions. But what if your doctor uses the phrase This terminology will probably still make a lot of people anxious and, in some situations, could result in some unnecessary treatment.

Several types of malignancies are associated with conditions that, while benign, could infer a more significant risk or likelihood of developing cancer in the future. Terminology including lesions, “stage 0” disease, or carcinoma “in situ” can all describe an abnormal, yet not malignant, finding. In addition to fear, these diagnoses can undoubtedly lead to patient confusion.

A diagnosis indicates abnormal cells present in a single location in the body. If a lesion isous, it has not spread to any other tissue, distant or nearby. This explains why theous conditions associated with several cancer types have names that involve the phrase “in situ,” which means “in its original place.”

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This is a bit technical. “nucleocytoplasmic compartmentalization assay”, Yeah buddy.

Life is dependent on the preservation and storage of information. The genome and epigenome are the two central storehouses of information in eukaryotes, and although they work interdependently, they are fundamentally quite different. Genetic information is consistent across all body cells throughout the life of an individual while epigenetic information varies between cells as well as changes over time and as per environment.

Researchers have identified several hallmarks of aging such as epigenetic alterations, genomic instability, cellular senescence, telomere attrition, mitochondrial dysfunction, and others [1]. These are known to play a role in the dysfunction and deterioration of cells with age. David Sinclair and other researchers have previously indicated that loss of epigenetic information can cause changes in gene expression, leading to cellular identity loss. Previous studies in mice have also shown that cell injuries such as cell crushing and DNA double-strand breaks can promote loss of epigenetic information which can accelerate aging along with age-related diseases [2].

Cellular senescence is a state of stable cell cycle arrest that can be triggered due to a wide range of extrinsic as well as intrinsic factors. It promotes tissue remodeling, wound repair, and cancer prevention by stopping the proliferation of damaged and aged cells. Senescent cells are characterized by metabolic and morphological alterations, reorganization of the chromatin, and release of pro-inflammatory substances known as the senescence-associated secretory phenotype (SASP) [3]. Irreparable DNA damage, loss of epigenetic information, and telomere shortening are a few factors that can initiate cellular senescence. Accumulation of senescent cells with age results in inflammation as well as the generation of reactive oxygen species (ROS).

Continue reading “Is the reversal of cellular aging possible through chemical means?” | >

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Oral Microbiome: https://www.bristlehealth.com/?ref=michaellustgarten.

Continue reading “Did DunedinPACE Improve For Test #5 in 2023? Also, Is NAD Significantly Correlated With DunedinPACE?” | >

When a group of researchers asked an AI to design a robot that could walk, it created a “small, squishy and misshapen” thing that walks by spasming when filled with air.

The researchers — affiliated with Northwestern University, MIT, and the University of Vermont — published their findings in an article for the Proceedings of the National Academy of Sciences on October 3.

“We told the AI that we wanted a robot that could walk across land. Then we simply pressed a button and presto!” Sam Kriegman, an assistant professor at Northwestern University and the lead researcher behind the study, wrote in a separate blog post.

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We are arguably at “the knee” of the curve. More breakthroughs have happened in the first 9 months of 2023 than all previous years from the turn of the century (2001 — 2022).

Will AGI kill us all? Will we join with it? Is it even close? Is it just “cool stuff”? Will we have bootstrapping self-improving AI?

The podcast crew today:
On the panel (left to right): Stefan Van Der Wel, Oliver Engelmann, Brendan Clarke.
Host camera: Roy Sherfan, Simon Carter.
Off camera: Peter Xing.

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