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Brain neurons re-entering the cell cycle age quickly and shift to senescence, particularly in neurodegenerative disease

Post-mitotic neurons in the brain that re-enter the cell cycle quickly succumb to senescence, and this re-entry is more common in Alzheimer’s disease, according to a new study published April 9 in the open-access journal PLOS Biology by Kim Hai-Man Chow and colleagues at the Chinese University of Hong Kong.

The phenomenon may provide an opportunity to learn more about the neurodegeneration process, and the technique used to make this discovery is readily applicable to other inquiries about unique populations of cells in the brain.

Most neurons in the brain are post-mitotic, meaning they have ceased to divide. For many years, it had been assumed that this post-mitotic state was permanent. Recent discoveries have shown that a small proportion of neurons re-enter the cell cycle, but little is known about their fate after they do.

Amazon ends California drone deliveries

Amazon confirmed it is ending Prime Air drone delivery operations in Lockeford, California. The Central California town of 3,500 was the company’s second U.S. drone delivery site, after College Station, Texas. Operations were announced in June 2022.

The retail giant is not offering details around the setback, only noting, “We’ll offer all current employees opportunities at other sites, and will continue to serve customers in Lockeford with other delivery methods. We want to thank the community for all their support and feedback over the past few years.”

College Station deliveries will continue, along with a forthcoming site in Tolleson, Arizona set to kick off deliveries later this year. Tolleson, a city of just over 7,000, is located in Maricopa County, in the western portion of the Phoenix metropolitan area.

Navigating The Generative AI Divide: Open-Source Vs. Closed-Source Solutions

If you’re considering how your organization can use this revolutionary technology, one of the choices that have to be made is whether to go with open-source or closed-source (proprietary) tools, models and algorithms.

Why is this decision important? Well, each option offers advantages and disadvantages when it comes to customization, scalability, support and security.

In this article, we’ll explore the key differences as well as the pros and cons of each approach, as well as explain the factors that need to be considered when deciding which is right for your organization.

MXenes-based energy storage devices could be charged in seconds

A team at Texas A&M University is taking significant steps for the development of a new generation of energy storage devices. They aim to develop a device that can combine the benefits of current technologies while addressing their limitations.

Dr. Abdoulaye Djire, a chemical engineering professor at Texas A&M University, as well as a few chemistry engineering graduates are focusing on MXenes, which is expected to be a compelling alternative to conventional lithium-ion batteries. Currently, the team is exploring the major advantages of nitride MXenes.