Lifeboat Foundation

The Klotho gene has gained increasing attention for its anti-aging properties. In the most recent installment of this series, we explored the promising cognitive benefits of administering Klotho to both mice and monkeys, the results from which may be mirrored in humans. The benefits of this circulating hormone, however, extend beyond the brain.

Klotho was first discovered as the antiaging gene in 1997 when researchers found that enhancing its expression could increase the lifespan of mice by more than 30%. Although a variety of different genes and environmental factors can influence longevity, studies have shown that Klotho-deficient mice not only have shorter lifespans but also experience more age-related complications. Premature aging in these mice often was accompanied by loss of muscle and fat tissue, thinning skin, reduced fertility, cardiovascular complications, movement abnormalities, and bone disease. Since Klotho is primarily produced in the kidneys, it is not surprising that many of these age-related complications often result from kidney dysfunction.

The kidneys generate two types of Klotho: a transmembrane protein that inserts itself into the cell membrane and mediates kidney function, and a secreted hormone that is released into the bloodstream. Individuals with naturally high levels of the hormone in their blood seem to not only live longer and be more resistant to age-related complications but also perform better on learning and memory tasks. In fact, even when a relatively small dose of Klotho is administered, animal studies have shown that the brain undergoes significant changes that allow more connections to be made in the hippocampus, the brain’s learning and memory center.

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There’s a lot of angst about software developers “losing their jobs” to AI, being replaced by a more intelligent version of ChatGPT, GitHub’s Copilot, Google’s foundation model Codey, or something similar.

AI startup founder Matt Welsh has been talking and writing about the end of programming. He’s asking whether large language models (LLMs) eliminate programming as we know it, and he’s excited that the answer is “yes”: Eventually, if not in the immediate future.

The researchers were successful in showing the relationship between activin A and bone erosion in cholesteatoma. “Our study showed that targeting activin A is a potential treatment in the management of cholesteatomas,” says senior author Masaru Ishii, MD, PhD, professor.

Currently in clinical settings, the only effective treatment for cholesteatomas is complete surgical removal. However, the discovery of how a cholesteatoma can cause bone erosion in this study offers new hope for developing novel medical treatments as first-line management for cholesteatomas.

“A cholesteatoma can still return or happen again even after its surgical removal, so it is important to know what is actually causing it,” notes lead author Kotaro Shimizu.

SpaceX performed a static fire test of a Super Heavy booster on Sunday to evaluate changes to the vehicle and launchpad following April’s maiden flight.

(CNN) — Astronomers have used the James Webb Space Telescope for a fresh perspective of an iconic celestial favorite called the Ring Nebula.

The new image captures never-before-seen details within the colorful nebula, located in the Lyra constellation about 2,600 light-years from Earth.

The structure of the Ring Nebula can be glimpsed through amateur telescopes and has been observed and studied for years.

Pythagoras first discovered that the vibrations of strings are drastically enhanced at certain frequencies. This discovery forms the basis of our tone system. Such natural vibrations ubiquitously exist in objects regardless of their size scales and are widely utilized to derive their species, constituents, and morphology. For example, molecular vibrations at a terahertz rate have become the most common fingerprints for the identification of chemicals and the structural analysis of large biomolecules.

Recently, natural vibrations of particles at the mesoscopic scale have received growing interest, since this category includes a wide range of functional particles, as well as most biological cells and viruses. However, natural vibrations of these mesoscopic particles have remained hidden from existing technologies.

These particles with sizes ranging from 100 nm to 100 μm are expected to vibrate faintly at megahertz to gigahertz rates. This frequency regime could not be resolved by current Raman and Brillouin spectroscopies, however, due to strong Rayleigh-wing scattering, while the performances of piezoelectric techniques that are widely exploited in macroscopic systems degrade significantly at frequencies beyond a few megahertz.

On any given day, Dallas motorists traveling along I-20 or I-45 are likely to be sharing the road with a self-driving truck that has the equivalent of a learner’s permit.

Why it matters: Dallas is the hub of autonomous truck testing and development, thanks to its vital freight corridors, business-friendly policies and generally favorable weather.

Read more about Airtel introduces Xstream AirFiber for ultimate 5G-powered wireless home Wi-Fi experience on Devdiscourse.

Beijing’s compromise of Tokyo’s classified cyber networks could prevent greater strategic coordination between Japan’s Defense Ministry and the Pentagon.