Lifeboat Foundation

The St. Francois Mountains of the Ozarks are full of geological wonders. Most know of the smooth shut-ins of the Black River or the house-size red boulders of Elephant Rocks State Park. But the Hughes Mountain Natural Area brings a site overlooked by tourists—the Devil’s Honeycomb.

The trail to the honeycombs can be a bit daunting, but the rewards are well worth it. In addition to sweeping views of Washington county, 1.5 billion-year-old Precambrian rock outcrops multiple at the mountain peak. These are some of the oldest exposed rocks in the United States. Volcanoes once liquified rocks in the area helping form the multi-sided rock columns. The rhyolite formations, known locally as the Devil’s Honeycomb, are one of Missouri’s geologic wonders. They are deep red in color and covered in sea-green lichens.

In the spring and summer, wildflowers fill in the cracks of the honeycomb. Rain pools in between the rhyolite, creating little bird baths. Lizards soak up the sun upon the rocks. Even prickly pear cactus grows in the heat of the honeycomb.

A large team of cancer researchers affiliated with multiple institutions in Germany, working with a colleague from the U.S., has discovered some of the ways gut bacteria can positively impact treatments for cancer. In their study, published in the journal Nature, the group studied the impact of gut microbiota on chemotherapy given to patients with pancreatic ductal adenocarcinoma. Le Li and Florencia McAllister with the University of Texas MD Anderson Cancer Center, have published a News and Views piece in the same journal issue, outlining the work done by the team in Germany.

Prior research has shown that chemotherapy for pancreatic cancer that has metastasized sometimes works well but is sometimes ineffective, and this difference may be tied to dietary resistance, though its source is not known. In this new study, the team in Germany looked at the possibility that certain microorganisms in the gut microbiome play a role in the process.

The team began their work by looking at samples of the gut microbiome of pancreatic cancer patients and found differences between those responding to treatment and those who were not. They also found that mice with sterilized guts who received biome samples from mice responding to chemotherapy also responded well.

A new study of 30 million people found that even small amounts of exercise could lower risk for heart disease, certain cancers and early death.

Patients with a large cerebral infarction have better functional recovery when they receive endovascular therapy early on in addition to usual medical management, a new study shows.

The trial was stopped early because a planned interim analysis showed efficacy of endovascular therapy in this patient population. #Stroke

A new study provides evidence for better functional recovery after endovascular therapy from a population of large-infarction strokes that could contribute to changing clinical practice.

Bruce Willis has FTD. I always wondered if gene therapy could help. Apparently so did Passage Bio, and they are doing clinical trials.

FTD is a disorder that affects the frontal and temporal lobes of the brain, areas that control personality, executive function, and language. FTD is a form of early onset dementia and currently has no approved disease-modifying therapies. In approximately 5–10% of individuals with FTD, the disease occurs because of mutations in the GRN gene. These mutations cause a deficiency of progranulin that helps regulate cellular processes.

Continue reading “Gene Therapy Clinical Trial for Frontotemporal Dementia Has Begun” »

Tunneling reactions in chemistry are difficult to predict. The quantum mechanically exact description of chemical reactions with more than three particles is difficult, with more than four particles it is almost impossible. Theorists simulate these reactions with classical physics and must neglect quantum effects. But where is the limit of this classical description of chemical reactions, which can only provide approximations?

Roland Wester from the Department of Ion Physics and Applied Physics at the University of Innsbruck has long wanted to explore this frontier. “It requires an experiment that allows very precise measurements and can still be described quantum-mechanically,” says the experimental physicist. “The idea came to me 15 years ago in a conversation with a colleague at a conference in the U.S.,” Wester recalls. He wanted to trace the quantum mechanical tunnel effect in a very simple reaction.

Since the tunnel effect makes the reaction very unlikely and thus slow, its experimental observation was extraordinarily difficult. After several attempts, however, Wester’s team has now succeeded in doing just that for the first time, as they report in the current issue of the journal Nature.

Nvidia has released a new driver update enabling support for Video Super Resolution, which uses AI to improve the quality of most online videos.

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Continue reading “LEAKED: Elon’s Secret AI Lab, Tesla Mexico, Toyota Doomed” »

Thinks he now has the answer to time travel — but you thankfully won’t be needing a DeLorean like the hit 8’0s movie Back to the Future A scientist believes he has finally cracked the code to enable time travel after having a big ‘eureka’ moment as he lay in hospital.