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Penn Engineers have modified lipid nanoparticles (LNPs) — the revolutionary technology behind the COVID-19 mRNA vaccines — to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons. This breakthrough marks a significant step toward potential next-generation treatments for neurological diseases like Alzheimer’s and Parkinson’s.

In a new paper in Nano Letters, the researchers demonstrate how peptides — short strings of amino acids — can serve as precise targeting molecules, enabling LNPs to deliver mRNA specifically to the endothelial cells that line the blood vessels of the brain, as well as neurons.

This represents an important advance in delivering mRNA to the cell types that would be key in treating neurodegenerative diseases; any such treatments will need to ensure that mRNA arrives at the correct location. Previous work by the same researchers proved that LNPs can cross the BBB and deliver mRNA to the brain, but did not attempt to control which cells the LNPs targeted.

Scientists are debating whether concepts such as memory, consciousness, and communication can be applied beyond the animal kingdom, Zoë Schlanger wrote in our June 2024 issue.

“Consciousness was once seen as belonging solely to humans and a short list of nonhuman animals that clearly act with intention,” Schlanger wrote in an article adapted from her book, “The Light Eaters: How the Unseen World of Plant Intelligence Offers a New Understanding of Life on Earth.”

“Yet seemingly everywhere researchers look, they are finding that there is more to the inner lives of animals than we ever thought possible. Scientists now talk regularly about animal cognition; they study the behaviors of individual animals, and occasionally ascribe personalities to them. Some scientists now posit that plants should likewise be considered intelligent.”

“Not so long ago, treading even lightly in this domain could upend a scientist’s career,” Schlanger continued. The popular 1973 book “The Secret Life of Plants” included real science, but also featured wildly unscientific projection; many scientists were unable to reproduce its claims, Schlanger wrote, causing a decades-long avoidance of plant-behavior studies.

A decade later, a paper by David Rhoades, a zoologist and chemist at the University of Washington, proposed that trees were communicating with one another to defend against a caterpillar infestation. Rhoades was ridiculed by peers; his discovery ended up buried, even as it opened new lines of inquiry. “Four decades on, the idea that plants might communicate intentionally with one another remains a controversial concept in botany,” Schlanger wrote. Definitions of communication are slippery; intentionality is even harder to show.

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Insane Clown Posse’s Joseph Utsler, better known by his stage persona Shaggy 2 Dope, has an AI clone — and apparently, he’s a fan.

Hosted on the Google-backed Character. AI service — which, as a sidebar, Futurism has investigated extensively, repeatedly finding horrible things — the ICP cofounder’s digital doppelganger sounds like a slightly robotic version of the real thing.

The effect is so uncanny that Mr. Dope himself decided to hit the AI up and bring it onto his livestreamed vlog, “The Shaggy Show.”

While these earthquakes are not impacting Kilauea, one of the world’s most active volcanoes, it has been intermittently erupting since Dec. 23.

According to the latest update from the Hawaiian Volcano Observatory, the intensity of these eruptions, so-called “lava fountaining,” has strengthened after weakening in the days after the initial eruption.

Webcam observations by USGS scientists show that these eruptions are currently confined to its crater.