Lifeboat Foundation

Glucosepane is one of the most significant mechanisms of aging and yet very few people are working on it!

As we age skin and blood vessels lose their elasticity. People care too much about the skin and too little about the blood vessels, but that is always the way of it. Appearance first and substance later, if at all. Yet you can live inside an aged skin; beyond the raised risk of skin cancer its damaged state arguably only makes life less pleasant, and the present state of medical science can ensure that the numerous age-related dermatological dysfunctions can be kept to a state of minor inconvenience. Loss of blood vessel elasticity, on the other hand, will steadily destroy your health and then kill you. Arterial stiffening causes remodeling of the cardiovascular system and hypertension. The biological systems that regulate blood pressure become dysfunctional as blood vessels depart from ideal youthful behavior, creating a downward spiral of increasing blood pressure and reactions to that increase. Small blood vessels fail under the strain in ever larger numbers, damaging surrounding tissue. In the brain this damage contributes to age-related cognitive decline by creating countless tiny, unnoticed strokes. Ultimately this process leads to dementia. More important parts of the cardiovascular system are likely to fail first, however, perhaps causing a stroke, or a heart attack, or the slower decline of congestive heart failure.

From what is known today, it is reasonable to propose that the two main culprits driving loss of tissue elasticity are sugary cross-links generated as a byproduct of the normal operation of cellular metabolism and growing numbers of senescent cells. Elasticity is a property of the extracellular matrix, an intricate structure of collagens and other proteins created by cells. Different arrangements of these molecules produce very different structures, ranging from load-bearing tissues such as bone and cartilage to elastic tissues such as skin and blood vessel walls. Disrupting the arrangement and interaction of molecules in the extracellular matrix also disrupts its properties. Persistent cross-links achieve this by linking proteins together and restricting their normal range of motion. Senescent cells, on the other hand, secrete a range of proteins capable of breaking down or remodeling portions of the surrounding extracellular matrix, and altering the behavior of nearby cells for the worse.

Continue reading “Scores of Labs Should be Gearing Up to Work on Glucosepane Cross-Link Breakers, But Are They?” »

As excitement builds around the first plasma, scheduled for December, on the Wendelstein 7-X (W7-X) experiment in Greifswald, Germany, PPPL physicist Sam Lazerson can boast that he has already achieved results.

Lazerson, who has been working at the site since March, mapped the structure of the magnetic field, proving that the main magnet system is working as intended. This was achieved using the trim coils that PPPL designed and had built in the United States. He presented his research at the APS Division of Plasma Physics Conference in Savannah, Georgia, on Nov. 18.

PPPL leads U.S. laboratories that are collaborating with the Max Planck Institute for Plasma Physics in experiments on the W7-X, the largest and most advanced stellarator in the world. It will be the first optimzed stellarator fusion facility to confine a hot plasma in a steady state for up to 30 minutes. In doing so, it will demonstrate that an optimized stellarator could be a model for future fusion reactors.

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If human-less self-driving cars of the future creep you out, then this latest experimental automotive technology from China might offer you some respite. Or freak creep you out even more. Researchers from the port city of Tianjin have revealed what they claim is the country’s first ever car to be driven without the use of human hands or feet but with a driver still in control. All it takes is some brain power. And some highly specialized equipment, of course.

Mind-reading devices aren’t actually new. In fact, many companies and technologies make that claim year after year, but few have actually been able to deliver an actual consumer product, with most successful prototypes designed for therapeutic or medical uses. The theory, however, is the same throughout. Sensors read electroencephalogram or EEG from the wearer’s brain. These are then interpolated and interpreted as commands for a computer. In this case, the commands are mapped to car controls.

The application of direct brain control to driving is a two-edged sword. On the one hand, removing the delay between brain to muscle movement, which sometimes can be erroneous, could actually lead to better driver safety. On the other hand, given how easily drivers can be distracted even while their hands are on the wheel, the idea is understandably frightening to some.

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Google appears to be more confident about the technical capabilities of its D-Wave 2X quantum computer, which it operates alongside NASA at the U.S. space agency’s Ames Research Center in Mountain View, California.

D-Wave’s machines are the closest thing we have today to quantum computing, which work with quantum bits, or qubits — each of which can be zero or one or both — instead of more conventional bits. The superposition of these qubits can allow great numbers of computations to be performed simultaneously, making a quantum computer highly desirable for certain types of processes.

In two tests, the Google Quantum Artificial Intelligence (AI) Lab today announced that it has found the D-Wave machine to be considerably faster than simulated annealing — a simulation of quantum computation on a classical computer chip.

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Big Hero 6’s programmable nanobots are on the horizon.

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Can we end violence? Can we create greater emotional well being and intellectual equality for the greater well being of humanity? Will we be able to keep up with machines? How can we augment our intelligence? Could we cure mental illness? After advancements in aging the next major area of research from a standpoint of eliminating personal and global suffering would be upgrades in intelligence. Transhumanist values at their core want to eliminate suffering and existential risk to people’s lives. With well founded logic, these goals are not completely out of reach, it is possible but as usual, we will have to take the complex issue from many angles and from the standpoint of a systems engineer, but let’s look at some fun stuff before we get into the heavy stuff.

The Benefits of Intelligence Upgrades

Continue reading “Transhumanism Solving Violence and Improving the Human Condition: IQ, EQi, and Intelligence Upgrades” »

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If humankind successfully lands people on the surface of Mars, we could discover an important clue about the origins of life on Earth — one of the greatest scientific mysteries in human history.

A theory called panspermia, which dates back to the 5th century BC, posits that certain life forms can hop between planets, and even star systems, to fertilize them with life.

Following this theory, some scientists suspect that the first life on Earth never formed on our planet at all, but instead, hitched a ride inside planetary fragments from Mars that were flung into space after a powerful impact and eventually fell to Earth. We could be the aliens!

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