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CRISPR-Cas is used broadly in research and medicine to edit, insert, delete or regulate genes in organisms. TnpB is an ancestor of this well-known “gene scissors” but is much smaller and thus easier to transport into cells.

Using protein engineering and AI algorithms, University of Zurich researchers have now enhanced TnpB capabilities to make DNA editing more efficient and versatile, paving the way for treating a genetic defect for high cholesterol in the future. The work has been published in Nature Methods.

CRISPR-Cas systems, which consist of protein and RNA components, were originally developed as a natural defense mechanism of bacteria to fend off intruding viruses. Over the last decade, re-engineering these so-called “gene scissors” has revolutionized genetic engineering in science and medicine.

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Johns Hopkins Medicine scientists who arranged for 48 human bioengineered heart tissue samples to spend 30 days at the International Space Station report evidence that the low gravity conditions in space weakened the tissues and disrupted their normal rhythmic beats when compared to Earth-bound samples from the same source.

The scientists said the heart tissues “really don’t fare well in space,” and over time, the tissues aboard the space station beat about half as strongly as tissues from the same source kept on Earth.

The findings, they say, expand scientists’ knowledge of low gravity’s potential effects on astronauts’ survival and health during long space missions, and they may serve as models for studying heart muscle aging and therapeutics on Earth.

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Although our universe may seem stable, having existed for a whopping 13.7 billion years, several experiments suggest that it is at risk—walking on the edge of a very dangerous cliff. And it’s all down to the instability of a single fundamental particle: the Higgs boson.

In new research by me and my colleagues, just accepted for publication in Physical Letters B, we show that some models of the early universe, those which involve objects called light primordial black holes, are unlikely to be right because they would have triggered the Higgs boson to end the cosmos by now.

The Higgs boson is responsible for the mass and interactions of all the particles we know of. That’s because particle masses are a consequence of elementary particles interacting with a field, dubbed the Higgs field. Because the Higgs boson exists, we know that the field exists.

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A suspected nation-state adversary has been observed weaponizing three security flaws in Ivanti Cloud Service Appliance (CSA) a zero-day to perform a series of malicious actions.

That’s according to findings from Fortinet FortiGuard Labs, which said the vulnerabilities were abused to gain unauthenticated access to the CSA, enumerate users configured in the appliance, and attempt to access the credentials of those users.

“The advanced adversaries were observed exploiting and chaining zero-day vulnerabilities to establish beachhead access in the victim’s network,” security researchers Faisal Abdul Malik Qureshi, John Simmons, Jared Betts, Luca Pugliese, Trent Healy, Ken Evans, and Robert Reyes said.

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France and Germany are joining the coalition at a time of heightened tension in space, with both China and Russia demonstrating their ability to disrupt or destroy satellites. Operation Olympic Defender aims to deter such actions through collective defense, shared intelligence, and the promotion of international norms for responsible space activity.

Germany’s official entry into Operation Olympic Defender was marked by a formal ceremony in Berlin, where Whiting joined Lt. Gen. Gunter Schneider, director-general for military strategy and operations at the German Ministry of Defence, and representatives from Australia, Canada, New Zealand and the United Kingdom.

“Space is truly a team sport. The addition of Germany to our roster of growing like-minded partners contributes to our collective ability to address the growing threats in the domain,” said Whiting.

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