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Mapping AI’s brain reveals memory and reasoning are not located in the same place

Researchers studying how large AI models such as ChatGPT learn and remember information have discovered that their memory and reasoning skills occupy distinct parts of their internal architecture. Their insights could help make AI safer and more trustworthy.

AI models trained on massive datasets rely on at least two major processing features. The first is memory, which allows the system to retrieve and recite information. The second is reasoning, solving new problems by applying generalized principles and learned patterns. But up until now, it wasn’t known if AI’s memory and general intelligence are stored in the same place.

So researchers at the startup Goodfire.ai decided to investigate the internal structure of large language and vision models to understand how they work.

Once considered quality problems, substrate defects now enable precise control of semiconductor crystal growth

A team led by researchers at Rensselaer Polytechnic Institute (RPI) has made a breakthrough in semiconductor development that could reshape the way we produce computer chips, optoelectronics and quantum computing devices.

The team, which also includes researchers from the National High Magnetic Field Laboratory, Florida State University and SUNY Buffalo, published their findings last month in Nature. Their work deepens the understanding of remote epitaxy, a manufacturing technique that entails growing high-quality semiconducting films on one substrate and then transferring them to a different one.

Remote epitaxy works by placing a thin buffer layer between a substrate and a growing crystal film. The substrate’s atomic structure guides the crystal’s growth through the buffer, but the buffer prevents permanent bonding—meaning that the finished crystal layer can be peeled off and moved elsewhere.

Spray 3D concrete printing simulator boosts strength and design

Concrete 3D printing reduces both time and cost by eliminating traditional formwork, the temporary mold for casting. Yet most of today’s systems rely on extrusion-based methods, which deposit material very close to a nozzle layer by layer. This makes it impossible to print around reinforcement bars (rebars) without risk of collision, limiting both design flexibility and structural integrity of builds.

Kenji Shimada and researchers in his Carnegie Mellon University’s Computational Engineering and Robotics Laboratory (CERLAB), are breaking through that limitation with a new simulation tool for spray-based concrete 3D .

“Spray-based concrete 3D printing is a new process with complicated physical phenomena,” said Shimada, a professor of mechanical engineering. “In this method, a modified shotcrete mixture is sprayed from a nozzle to build up on a surface, even around rebar.”

Research reveals shared genetic roots for psychiatric and neurological disorders

Researchers from the Center for Precision Psychiatry at the University of Oslo and Oslo University Hospital have discovered extensive genetic links between neurological disorders like migraine, stroke and epilepsy, and psychiatric illnesses such as schizophrenia and depression. Published in Nature Neuroscience, this research challenges longstanding boundaries between neurology and psychiatry and points to the need for more integrated approaches to brain disorders.

“We found that psychiatric and neurological disorders share to a greater extent than previously recognized. This suggests that they may partly arise from the same underlying biology, contrasting the traditional view that they are separate disease entities. Importantly, the genetic risk was closely linked to brain biology,” states Olav Bjerkehagen Smeland, psychiatrist and first author.

Infants born with hearing loss show disruptions in brain design, underscoring the urgency of intervention

Infants born deaf or hard of hearing show adverse changes in how their brains organize and specialize, but exposure to sound and language may help them develop more normally, according to new research.

The study led by two neuroscientists found that infants with (SNHL) lacked the usual pattern of organization on the brain’s left side, which supports language and higher cognitive skills.

The findings also suggest that early auditory stimulation through hearing aids or , along with exposure to language, whether spoken or signed, could help preserve .

Nonsurgical treatment shows promise for targeted seizure control

Rice University bioengineers have demonstrated a nonsurgical way to quiet a seizure-relevant brain circuit in an animal model. The team used low-intensity focused ultrasound to briefly open the blood-brain barrier (BBB) in the hippocampus, delivered an engineered gene therapy only to that region and later flipped an on-demand “dimmer switch” with an oral drug.

The research shows that a one-time, targeted procedure can modulate a specific brain region without impacting off-target areas of the brain. It is published in and featured on the cover of ACS Chemical Neuroscience.

“Many are driven by hyperactive cells at a particular location in the brain,” said study lead Jerzy Szablowski, assistant professor of bioengineering and a member of the Rice Neuroengineering Initiative. “Our approach aims the therapy where it is needed and lets you control it when you need it, without surgery and without a permanent implant.”

It’s not just in your head: Stress may lead to altered blood flow in the brain

While the exact causes of neurodegenerative brain diseases like Alzheimer’s and dementia are still largely unknown, researchers have been able to identify a key characteristic in affected brains: reduced blood flow. Building upon this foundational understanding, a team at Penn State recently found that a rare neuron that is extremely vulnerable to anxiety-induced stress appears to be responsible for regulating blood flow and coordinating neural activity in mice.

The researchers found that eliminating type-one nNOS neurons—which make up less than 1% of the brain’s 80 billion neurons and die off when exposed to too much stress—resulted in a drop in both blood flow and in mice’s brains, demonstrating the impact this neuron type has on the proper brain functions of animals, including humans.

The research appears in eLife.

Angstrom-level imaging and 2D surfaces allow real-time tracking and steering of DNA

Pictures of DNA often look very tidy—the strands of the double helix neatly wind around each other, making it seem like studying genetics should be relatively straightforward. In truth, these strands aren’t often so perfectly picturesque. They are constantly twisting, bending, and even being repaired by minuscule proteins. These are movements on the nanoscale, and capturing them for study is extremely challenging. Not only do they wriggle about, but the camera’s fidelity must be high enough to focus on the tiniest details.

Researchers from the University of Illinois Urbana-Champaign (U. of I.) have been working on resolving a grand challenge for , and more specifically, : how to take a high-resolution image of DNA to facilitate study.

Using a number of compute resources, including NCSA’s Delta, Aleksei Aksimentiev, a professor of physics at U. of I, and Dr. Kush Coshic, formerly a graduate research assistant in the Center for Biophysics and Quantitative Biology and the Beckman Institute for Advanced Science and Technology at U. of I., and currently a postdoctoral fellow at the Max Planck Institute of Biophysics, recently made significant contributions to solving this challenge. They did it by focusing on two specific problems: creating a “camera” that could capture the molecular movement of DNA, and by creating an environment in which they could predictably direct the movement of the DNA strands.

Nanorobots guide stem cells to become bone cells via precise pressure

For the first time, researchers at the Technical University of Munich (TUM) have succeeded in using nanorobots to stimulate stem cells with such precision that they are reliably transformed into bone cells. To achieve this, the robots exert external pressure on specific points in the cell wall. The new method offers opportunities for faster treatments in the future.

Prof. Berna Özkale Edelmann’s nanorobots consist of tiny gold rods and plastic chains. Several million of them are contained in a gel cushion measuring just 60 micrometers, together with a few . Powered and controlled by , the robots, which look like tiny balls, mechanically stimulate the cells by exerting pressure.

“We heat the gel locally and use our system to precisely determine the forces with which the nanorobots press on the cell—thereby stimulating it,” explains the professor of nano-and microrobotics at TUM. This mechanical stimulation triggers biochemical processes in the cell. Ion channels change their properties, and proteins are activated, including one that is particularly important for bone formation.

Metasurfaces show promise in boosting AR image clarity and brightness

Researchers have designed and demonstrated a new optical component that could significantly enhance the brightness and image quality of augmented reality (AR) glasses. The advance brings AR glasses a step closer to becoming as commonplace and useful as today’s smartphones.

“Many of today’s AR headsets are bulky and have a short battery life with displays that are dim and hard to see, especially outdoors,” said research team leader Nick Vamivakas from the University of Rochester. “By creating a much more efficient input port for the display, our work could help make AR glasses much brighter and more power-efficient, moving them from being a niche gadget to something as light and comfortable as a regular pair of eyeglasses.”

In an article published in the journal Optical Materials Express, the researchers describe how they replaced a single waveguide in-coupler—the input port where the image enters the glass—with one featuring three specialized zones, each made of a material, to achieve improved performance.

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