Lifeboat Foundation

Nanoparticles are particles that are smaller than 100 nanometers. They are typically obtained from metals and, because of their tiny size, have unique properties that make them useful for biomedical applications. However, without treatment to make their surfaces biologically inert, their effectiveness is severely limited. Researchers led by Kazuhiko Ishihara at the University of Tokyo have pioneered the use of MPC polymers to modify the surfaces of nanoparticles. In a recent article published in the journal Science and Technology of Advanced Materials, they reviewed current ways in which polymeric nanoparticles can be used to transport a type of small nanoparticles called quantum dots into cells.

Cells can uptake polymer nanoparticles embedding quantum dots covered with cytocompatible phospholipid polymer and cell-penetrating peptides. © 2016 Kazuhiko Ishihara, Weixin Chen, Yihua Liu, Yuriko Tsukamoto and Yuuki Inoue.

MPC polymers are large molecules made from chains of 2-methacryloyloxyethyl phosphorylcholine (MPC). Bioactive nanoparticles whose surfaces have been modified with them can be used as anti-tumor compounds, gene carriers, contrast agents that improve MRI images, and protein detectors. MPC polymers mimic cellular membranes and allow the delivery of bioactive molecules that are normally not very soluble in water or that might produce unwanted biological side effects. When scientists attach MPC polymers to the surface of inorganic nanoparticles, they can make substances that are easily delivered into the blood or other tissue.

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2,000km network to provide foundation for secure quantum key distribution.

Engineers from Yale University have developed a new technique to control the frequency of single photons.

The ability to control the frequency of single photons is crucial to realize the potential of quantum communications and quantum computing. The current methods for changing photon frequency, however, bring with them significant drawbacks.

Researchers in the lab of Hong Tang, the Llewellyn West Jones, Jr. Professor of Electrical Engineering & Physics, have developed a technique that avoids these obstacles. The results of their work are published today in Nature Photonics. Linran Fan, a Ph.D. student in Tang’s lab, is the lead author.

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In the future, circuits and systems modelled on human brains could end up in everything from supercomputers to everyday smartphones.

Scientists from the University of Basel have succeeded in organizing spherical compartments into clusters mimicking the way natural organelles would create complex structures. They managed to connect the synthetic compartments by creating bridges made of DNA between them. This represents an important step towards the realization of so-called molecular factories. The journal Nano Letters has published their results.

Within a cell there are specialized compartments called organelles, as for example nucleus, mitochondria, peroxisomes and vacuoles that are responsible for specific functions of the cell. Almost all sophisticated biological functions of cells are realized by self-organization, a process by which molecules adopt a defined arrangement based on their specific conformations and properties, without outside guidance.

Using self-organization of nano-objects into complex architectures is a major strategy to produce new materials with improved properties or functionalities in fields such as chemistry, electronics and technology. For example, this strategy has already been applied to create networks of inorganic solid nanoparticles. However, so far, these networks were not able to mimic sophisticated structures that have biological functions within the cells and thus have potential application in medicine or biology.

2 November 2016. Two companies partnering with Auburn University developed a synthetic virus to find and destroy tumor cells in a type of bone cancer in dogs. Financial and intellectual property aspects of the agreement between synthetic gene company Gen9 in Cambridge, Massachusetts, design systems developer Autodesk Inc. in San Rafael, California, and Auburn University College of Veterinary Medicine in Alabama were not disclosed.

The research team created a synthetic version of canine adenovirus type 2, or CAV2, a virus usually associated with hepatitis in dogs. In this case, the synthetic CAV-2 virus is designed as an oncolytic virus that finds and attacks cancer cells, while leaving healthy cells and tissue intact. The genome in the organism is believed to be the longest in a functional virus synthesized for cancer research, with about 34,000 base pairs of nucleic acids. The human genome, by comparison, has about 3 billion base pairs.

The technology provided by Gen9 in this project makes it possible to eventually produce synthetic therapeutic viruses tailored for specific patients. Gen9 offers customized gene synthesis and is developing a library of synthesized proteins and antibodies. One of the 4 year-old company’s founders is George Church, a geneticist at Harvard Medical School and serial entrepreneur. In August 2016, as reported in Science & Enterprise, Church and colleagues, including those from Gen9, developed a synthetic E. coli bacteria genome with redundant DNA components removed.

When the future of genetic engineering arrived on Sebastian Cocioba’s doorstep, it was affixed to the back of a postcard from Austria with a little bit of packing tape.

Cocioba is a 25-year-old college dropout whose primary interest is tinkering with plant genetics in a lab he cobbled together from eBay. The lab is located in the spare bedroom of his parent’s lavish apartment in Long Island City, across the river from Manhattan. A few months ago, an internet friend from an online bio-hacking forum had sent him the lab’s latest addition: attached to that postcard was Crispr-Cas9.

Inverse doing a recap from my AMA on Reddit’s Futurology. My AMA is going on for about another 15 hours, so if you have a question, please chime in there: https://www.inverse.com/article/23120-zoltan-istvan-formula-1-sports-future and here’s the AMA:

https://www.reddit.com/r/Futurology/comments/5aq3mw/ama_im_z…manist_us/ #transhumanism #AMA #ScienceCandidate #Election2016

The U.S. presidential candidate has shared some of his future goals ahead of voting day.

Continue reading “Transhumanist Zoltan Istvan: Formula 1 is Future of Human Sports” »

We now know the mass of an axion, which means we might be able to prove dark matter does indeed exist.