[p]Patients with junctional epidermolysis bullosa (JEB) carry mutations in genes that encode components of the basement membrane, which ensures the integrity between the epidermis and the dermis, such as laminin-332. These mutations cause blistering of the skin and chronic wounds. Following initial treatment of an adult patient with a limited affected region, Michele De Luca and colleagues reconstruct the full epidermis of a 7-year-old patient with autologous transgenic cells transduced with a virus vector carrying the non-mutated form of laminin-322.
In a move that can only be considered controversial, the first pig-human hybrid has been successfully created in a lab. Researchers managed to grow human cells inside early-stage pig embryos, which led to the creation of the first pig-human hybrids ever made. The result is described as interspecies chimeras.
Though the experiment is still in its early days, scientists think the “breakthrough” would possibly one day lead to lab-grown human organs that would be transplanted into people who need them. If the experiment is successful, hundreds of thousands of lives could be saved.
Paul Bedard at the Washington Examiner wrote in his “Washington Secrets” column that the White House “is being warned that North Korea is mapping plans for a ‘devastating’ attack on the United States with an atmospheric nuclear explosion that would disable the nation’s electric grid, potentially leading to the deaths of virtually all impacted.”
He said President Trump “is being urged to create a special commission to tackle the potential for an electromagnetic pulse attack, one similar to the iconic Manhattan Project.”
A controversial plan to cool down the planet by artificially simulating volcanic eruptions could have disastrous consequences for Earth—yet there are no laws or regulations to stop any country or private company from deploying such technology.
Solar geoengineering is one of the proposed ways to artificially reduce global temperatures. It is often seen as one of the most extreme options—but also potentially one of the most effective. It involves injecting aerosols into the atmosphere. When the gas combines with oxygen, droplets of sulfuric acid form. These droplets reflect sunlight away, cooling the planet in the process. All good in theory, but the consequences of solar geoengineering are largely unknown.
In a study published in Nature Communications, scientists led by Anthony Jones, from the University of Exeter, U.K., have now examined what would happen if solar geoengineering was used in the Northern Hemisphere to try to prevent global warming and the extreme weather that goes with it—in this case tropical cyclones.
For the first time ever, scientists have attempted to cure a person’s disease by editing a gene inside the body.
Scientists used an IV to inject a patient with billions of copies of a corrective gene and a genetic tool to cut his DNA in a specific spot. “We cut your DNA, open it up, insert a gene, stitch it back up.”
Scientists have edited people’s genes in the past, but that work involved altering cells inside a lab and then returning them to the body, whereas the latest experiment was performed inside a person’s body.
He is the first patient to receive an experimental gene therapy as part of a clinical trial. Earlier this week, Sangamo Therapeutics injected Madeux with viruses containing a package of gene-editing material, according to the AP. The hope is that these viruses will enter Madeux’s cells, specifically liver cells, inject the missing gene at the right place in his DNA. Only about 1% of the liver’s cells need to be fixed, and give his liver the ability to produce the enzyme he has been missing all his life.
Brian Madeux’s life hasn’t been easy. So far, he’s had 26 operations to fix problems in everything from hernias to eyes. He has a rare disease called Hunter syndrome, which is caused by the lack of a gene that’s used to produce an enzyme that breaks down certain carbohydrates. As a result, the carbohydrates build up in his body’s cells causing all sorts of problems.
There is no cure. One way to deal with some of the symptoms is to receive regular doses of the missing enzyme, which may cost him in the US between $100,000 and $400,000 per year. Even then, the enzyme won’t reverse the damage made already and it won’t stop further deterioration that happens in the brain.
There is no doubt that the arrival of rejuvenation biotechnology will not only change how we age but also how society works. Eradicating age-related diseases will lead to challenges for our society but we should be positive about change and a healthier future.
A very useful skill you get from the study of mathematics is the ability to skim details off a special case of a concept and get to the general case, which is the essence common to all special cases. This skill, far from being useful only in maths and science, can be applied to a variety of situations, including—perhaps surprisingly—rejuvenation advocacy.
Think about common objections to rejuvenation: won’t it cause overpopulation? Won’t it make it impossible to pay the pensions? Won’t it make it harder for the young to find a job? Won’t it change our perception of older people and our idea of family?
The answers to these questions are more complicated than just yes or no, but this is not what we’re concerned with here. All of these questions above are special cases of a more general case.
T Cells are a major component of the formidable immune system that the body keeps at the ready to respond to the first sign of infection or disease. T cells detect if cells have been infected with a virus; upon detection, they trigger these cells’ ablation and destroy the virus.
Unfortunately, the T cells do not detect cancer cells, as these cells use various tricks to fool the immune system into believing that they are normal healthy cells. Thus, they hide in plain sight, and the T cells cannot seek and destroy them. A new study has found a possible solution to this problem.
